DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZnT63C and ZRC1

DIOPT Version :9

Sequence 1:	NP_001261364.1	Gene:	ZnT63C / 38407	FlyBaseID:	FBgn0035432	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_013970.1	Gene:	ZRC1 / 855284	SGDID:	S000004856	Length:	442	Species:	Saccharomyces cerevisiae

Alignment Length:	443	Identity:	170/443 - (38%)
Similarity:	244/443 - (55%)	Gaps:	66/443 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SGKKCRLLSMMWLTAFFFFVEIIVGYVTNSMALVADSFHMLGDIAALVISFLSVKMSPKKW--SK 67
            :||:.|::|::.|...||.:||.:||:::|:||:|||||||.||.:|:::..:|.::..:.  :|
Yeast     3 TGKELRIISLLTLDTVFFLLEITIGYMSHSLALIADSFHMLNDIISLLVALWAVDVAKNRGPDAK 67

  Fly    68 NTFGWARAEVLGALVNAVFLVALCFSITIEACKRFIEEEPIHEPELLVIVGALGLLVNVIGLCLL 132
            .|:||.|||:||||:|||||:||||||.|||.:|.||.:.|..|.|::.||..||:.||:||.|.
Yeast    68 YTYGWKRAEILGALINAVFLIALCFSIMIEALQRLIEPQEIQNPRLVLYVGVAGLISNVVGLFLF 132

  Fly   133 YEHGGH--HGHSHG------------GGLTRNHSRLTELAN----MDE------------GEDEQ 167
            ::||..  |.||||            ...|.:||. ..|.|    :||            ||...
Yeast   133 HDHGSDSLHSHSHGSVESGNNDLDIESNATHSHSH-ASLPNDNLAIDEDAISSPGPSGQIGEVLP 196

  Fly   168 NDFAYEKQKEKAP-VKKSSHGHSHD---PG--QMNMRGAFLHVLSDALGSIIVVISAVVVWKTEW 226
            .........|..| :....|.|||:   ||  .:||.|.|||||.||||:|.|:.:|:.:||||:
Yeast   197 QSVVNRLSNESQPLLNHDDHDHSHESKKPGHRSLNMHGVFLHVLGDALGNIGVIAAALFIWKTEY 261

  Fly   227 KYRYYMDPALSIVLVVLILHSVWPLLRESALILLQTVPTHIQVDAIQKRLLEKVDGVLAVHEFHV 291
            .:|||.||.:|:::.::|..|..||.|.::.||||..|:.|..|.||:.:| .|.||:|||:|||
Yeast   262 SWRYYSDPIVSLIITIIIFSSALPLSRRASRILLQATPSTISADQIQREIL-AVPGVIAVHDFHV 325

  Fly   292 WQLAGDRIIASAHIR--CRNLSEYMKIAEKVKEFFHNEGIHSTTIQPE-------------FSEI 341
            |.|.....|||.|::  |.. .::|..|:.:::.||..||||.|:|||             ||.|
Yeast   326 WNLTESIYIASIHVQIDCAP-DKFMSSAKLIRKIFHQHGIHSATVQPEFVSGDVNEDIRRRFSII 389

  Fly   342 EGCNMSDGTSSINISGS--------DCCALDCPTTEEGCV--KATCCQNNNKL 384
            .|.:.|....:.:..|:        ...|....|....|:  .|..|..:|.|
Yeast   390 AGGSPSSSQEAFDSHGNTEHGRKKRSPTAYGATTASSNCIVDDAVNCNTSNCL 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZnT63C	NP_001261364.1	CzcD	10..339	CDD:224151	155/381 (41%)
ZnT63C	NP_001261364.1	Cation_efflux	21..260	CDD:279834	115/276 (42%)
ZRC1	NP_013970.1	CzcD	6..375	CDD:224151	155/371 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344014
Domainoid	1	1.000	205	1.000	Domainoid score	I532
eggNOG	1	0.900	-	-		E1_COG1230
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6681
Inparanoid	1	1.050	281	1.000	Inparanoid score	I557
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51881
OrthoFinder	1	1.000	-	-		FOG0002109
OrthoInspector	1	1.000	-	-		otm46809
orthoMCL	1	0.900	-	-		OOG6_102585
Panther	1	1.100	-	-	O	PTHR45820
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2014
SonicParanoid	1	1.000	-	-		X1398
TreeFam	1	0.960	-	-
	15	14.790