DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZnT63C and COT1

DIOPT Version :9

Sequence 1:	NP_001261364.1	Gene:	ZnT63C / 38407	FlyBaseID:	FBgn0035432	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_014961.3	Gene:	COT1 / 854494	SGDID:	S000005843	Length:	439	Species:	Saccharomyces cerevisiae

Alignment Length:	444	Identity:	159/444 - (35%)
Similarity:	236/444 - (53%)	Gaps:	71/444 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KYSGKKCRLLSMMWLTAFFFFVEIIVGYVTNSMALVADSFHMLGDIAALVISFLSVKMSPKK--W 65
            |...|:.:::|::.|...||.:||..||:::|:||:|||||||.||.:||::..:|.::..:  .
Yeast     2 KLGSKQVKIISLLLLDTVFFGIEITTGYLSHSLALIADSFHMLNDIISLVVALWAVNVAKNRNPD 66

  Fly    66 SKNTFGWARAEVLGALVNAVFLVALCFSITIEACKRFIEEEPIHEPELLVIVGALGLLVNVIGLC 130
            |..|:||.|||:||||:|||||:|||.||.|||.:|.|....|..|:.::.||..||:.|.:||.
Yeast    67 STYTYGWKRAEILGALINAVFLIALCVSILIEALQRIIAPPVIENPKFVLYVGVAGLISNTVGLF 131

  Fly   131 LLY----EHGGHHGHSHGG---------------------GL--------TRNHSRLTELANMDE 162
            |.:    |||..|||||||                     |:        |.|.|.:...|.:|.
Yeast   132 LFHDNDQEHGHGHGHSHGGIFADHEMHMPSSHTHTHAHVDGIENTTPMDSTDNISEIMPNAIVDS 196

  Fly   163 GEDEQNDFAYEKQKEKAP-VKKSSH---------GHSHDPGQMNMRGAFLHVLSDALGSIIVVIS 217
            ..:|.......:...|.| ...|||         .|:.....:||.|.|||||.||||:|.|::|
Yeast   197 FMNENTRLLTPENASKTPSYSTSSHTIASGGNYTEHNKRKRSLNMHGVFLHVLGDALGNIGVMLS 261

  Fly   218 AVVVWKTEWKYRYYMDPALSIVLVVLILHSVWPLLRESALILLQTVPTHIQVDAIQKRLLEKVDG 282
            |..:|||::.::||.||.:|:::..:|..|..||..:::.||||..|:.:..|.::..|| |:.|
Yeast   262 AFFIWKTDYSWKYYTDPLVSLIITGIIFSSALPLSCKASKILLQATPSTLSGDQVEGDLL-KIPG 325

  Fly   283 VLAVHEFHVWQLAGDRIIASAHIRCRNLS--EYMKIAEKVKEFFHNEGIHSTTIQPEF------- 338
            ::|:|:||:|.|.....|||.||:. ::|  ::..:|:.|:...|..||||.|:||||
Yeast   326 IIAIHDFHIWNLTESIFIASLHIQL-DISPEQFTDLAKIVRSKLHRYGIHSATLQPEFITREVTS 389

  Fly   339 SEIEGCNMSD-----------GTSSINISGSDCCALDCPTTEEGCVKATCCQNN 381
            :|..|.:..|           .|....||||.|...|.    ..|..|.|.:::
Yeast   390 TERAGDSQGDHLQNDPLSLRPKTYGTGISGSTCLIDDA----ANCNTADCLEDH 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZnT63C	NP_001261364.1	CzcD	10..339	CDD:224151	144/382 (38%)
ZnT63C	NP_001261364.1	Cation_efflux	21..260	CDD:279834	109/283 (39%)
COT1	NP_014961.3	CzcD	9..384	CDD:224151	144/376 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344013
Domainoid	1	1.000	205	1.000	Domainoid score	I532
eggNOG	1	0.900	-	-		E1_COG1230
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	281	1.000	Inparanoid score	I557
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51881
OrthoFinder	1	1.000	-	-		FOG0002109
OrthoInspector	1	1.000	-	-		otm46809
orthoMCL	1	0.900	-	-		OOG6_102585
Panther	1	1.100	-	-	O	PTHR45820
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2014
SonicParanoid	1	1.000	-	-		X1398
TreeFam	1	0.960	-	-
	14	13.790