DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZnT63C and Slc30a5

DIOPT Version :9

Sequence 1:	NP_001261364.1	Gene:	ZnT63C / 38407	FlyBaseID:	FBgn0035432	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_075023.2	Gene:	Slc30a5 / 69048	MGIID:	1916298	Length:	761	Species:	Mus musculus

Alignment Length:	363	Identity:	109/363 - (30%)
Similarity:	181/363 - (49%)	Gaps:	64/363 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 RLLSMMWLTAFFFFVEIIVGYVTNSMALVADSFHMLGDIAALVISFLSVKMSPKKWSKN---TFG 71
            ::...:.|...|.|||:..|.:|||:.|::|.||||.|.:|||:...:..||  :|...   ::|
Mouse   416 QIFYFLCLNLLFTFVELFYGVLTNSLGLISDGFHMLFDCSALVMGLFAALMS--RWKATRIFSYG 478

  Fly    72 WARAEVLGALVNAVFLVALCFSITIEACKRFIEEEPIHEPELLVIVGALGLLVNVIGLCLLYEHG 136
            :.|.|:|...:|.:||:.:.|.:.:|:..|.| :.|..:..:|..|...||:||:||:|..
Mouse   479 YGRIEILSGFINGLFLIVIAFFVFMESVARLI-DPPELDTNMLTPVSVGGLIVNLIGICAF---- 538

  Fly   137 GHHGHSHGGGLTRNHSRLTELANMDEGEDEQNDFAYEKQKEKAPVKKSSHGHSHDPG-------- 193
             .|.||||.|.::.:      .:.|.|....                 :|||.||.|
Mouse   539 -SHAHSHGHGASQGN------CHSDHGHSHH-----------------AHGHGHDHGHSHGFTGG 579

  Fly   194 --QMNMRGAFLHVLSDALGSIIVVISAVVVWKTEWKYRYYMDPALSIVLVVLILHSVWPLLRESA 256
              ..||||.|||||:|.||||.|::|.|::.:..|   :..||..|:.:.|||..||.||::::.
Mouse   580 GMNANMRGVFLHVLADTLGSIGVIVSTVLIEQFGW---FIADPLCSLFIAVLIFLSVIPLIKDAC 641

  Fly   257 LILLQTVP------THIQVDAIQKRLLEKVDGVLAVHEFHVWQLAGDRIIASAHIRCRNLSEYMK 315
            .:||..:|      .||.::.||     |::|:::..:.|.|:.:...:..:.||:..:.....:
Mouse   642 QVLLLRLPPDHEKELHIALEKIQ-----KIEGLISYRDPHFWRHSASIVAGTIHIQVTSEVLEQR 701

  Fly   316 IAEKVKEFFHNEGIHSTTIQPE----FSEIEGCNMSDG 349
            |.::|.....:.|:::.|||.|    |..:.|  :|.|
Mouse   702 IVQQVTGILKDAGVNNLTIQVEKEAYFQHMSG--LSTG 737

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZnT63C	NP_001261364.1	CzcD	10..339	CDD:224151	105/351 (30%)
ZnT63C	NP_001261364.1	Cation_efflux	21..260	CDD:279834	84/251 (33%)
Slc30a5	NP_075023.2	CDF	426..725	CDD:273544	104/337 (31%)
		Cation_efflux	426..645	CDD:279834	84/252 (33%)
		His-rich loop	540..574		14/56 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	549..576		8/49 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1230
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2014
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840