Protein Alignment ZnT63C and SLC30A6

DIOPT Version :9

• Sequence 1: NP_001261364.1
• Gene: ZnT63C / 38407
• FlyBaseID: FBgn0035432
• Length: 545
• Species: Drosophila melanogaster
• Sequence 2: NP_001180442.1
• Gene: SLC30A6 / 55676
• HGNCID: 19305
• Length: 501
• Species: Homo sapiens
• Alignment Length: 528
• Identity: 118/528 - (22%)
• Similarity: 186/528 - (35%)
• Gaps: 158/528 - (29%)

  Fly     4 YSGKKCRLLSMM------WLTAFFFFVEII-VGYV------TNSMALVADSFHMLGDIAALVIS- 54
            :.||..|...::      |....|..:.:| .|::      |||:||.|.::..:.|:....:|
Human    14 FFGKLLREFRLVAADRRSWKILLFGVINLICTGFLLMWCSSTNSIALTAYTYLTIFDLFRDGVSP 78

  Fly    55 -FLSVKMSPK-KWSKN--------------------------------------TFGWARAEVLG 79
             :|....:|. |||.:                                      :||:.|.|||.
Human    79 FWLGWSQTPDLKWSTHLGLPKCWDNRRELPCLSNSLMTCLISYWVTLRKPSPVYSFGFERLEVLA 143

  Fly    80 ALVNAVFLVALCFSITIEACKRFIEEEPIHEPELLVIVGALGLLVNVIGLCLLYEHGGHHGHSHG 144
            ...:.|........|..|:.:||:|:..||...||  ||..      :.||.
Human   144 VFASTVLAQLGALFILKESAERFLEQPEIHTGRLL--VGTF------VALCF------------- 187

  Fly   145 GGLTRNHSRLTELANMDEGEDEQNDFAYEK--------QKEKAPVKKSSHGHSHDPGQMNMRGAF 201
                 |...:..:.|        ..|||..        |:..|.:.:|..|..  ||   :...|
Human   188 -----NLFTMLSIRN--------KPFAYVSEAASTSWLQEHVADLSRSLCGII--PG---LSSIF 234

  Fly   202 L-----HVLSDALGSIIVVISAVVVWKTEWKYRYYMDPALSIVLVVLILHSVWPLLRESALILLQ 261
            |     .||.|..|:..:.|:.:::   |....:.:|.|.:|.:.::...:::|:...|..:|||
Human   235 LPRMNPFVLIDLAGAFALCITYMLI---EINNYFAVDTASAIAIALMTFGTMYPMSVYSGKVLLQ 296

  Fly   262 TVPTHI--QVDAIQKRLLEKVDGVLAVHEFHVWQLAGDRIIASAHIRC-RNLSEYMKIAEKVK-- 321
            |.|.|:  |:|.: .|.:..:||||.|...|.|.|....:..|.|:|. |:.:|.|.:|....
Human   297 TTPPHVIGQLDKL-IREVSTLDGVLEVRNEHFWTLGFGSLAGSVHVRIRRDANEQMVLAHVTNRL 360

  Fly   322 ---------EFFHNEGIHSTTIQ-PEFSEIEGCNMSD----------GTSSINISGSDCCALDCP 366
                     :.|.::.|....:. |..:.:  .|.||          ||..:|...|.......|
Human   361 YTLVSTLTVQIFKDDWIRPALLSGPVAANV--LNFSDHHVIPMPLLKGTDDLNPVTSTPAKPSSP 423

  Fly   367 TTEEGCVKATCCQNNNKLNQLPSPTNSPYLCRQRNAARQAGDVEAGSLLEATSSGNQ-------G 424
            ..|...  .|..:|.|.:..|.:.|. ||     ......|.....|:|      ||       |
Human   424 PPEFSF--NTPGKNVNPVILLNTQTR-PY-----GFGLNHGHTPYSSML------NQGLGVPGIG 474

  Fly   425 ATGGASTG 432
            ||.|..||
Human   475 ATQGLRTG 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ZnT63C	NP_001261364.1	CzcD	10..339	CDD:224151	89/410 (22%)
		Cation_efflux	21..260	CDD:279834	60/299 (20%)
SLC30A6	NP_001180442.1	CzcD	<113..371	CDD:224151	68/300 (23%)
		Cation_efflux	113..295	CDD:279834	44/223 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1230
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810