DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZnT63C and SLC30A10

DIOPT Version :9

Sequence 1:	NP_001261364.1	Gene:	ZnT63C / 38407	FlyBaseID:	FBgn0035432	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_061183.2	Gene:	SLC30A10 / 55532	HGNCID:	25355	Length:	485	Species:	Homo sapiens

Alignment Length:	434	Identity:	155/434 - (35%)
Similarity:	237/434 - (54%)	Gaps:	75/434 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAKYSGKKCRLLSMMWLTAFFFFVEIIVGYVTNSMALVADSFHMLGDIAALVISFLS--VKMSPK 63
            |.:||||.||||.|:.||..||..|::.||:.||:||::|||:||.|:.:|.:...:  :...|.
Human     1 MGRYSGKTCRLLFMLVLTVAFFVAELVSGYLGNSIALLSDSFNMLSDLISLCVGLSAGYIARRPT 65

  Fly    64 KWSKNTFGWARAEVLGALVNAVFLVALCFSITIEACKRFIEEEPIHEPELLVIVGALGLLVNVIG 128
            :....|:|:|||||:|||.|||||.||||:|.:||..|....|.|.:|||::|||.|||||||:|
Human    66 RGFSATYGYARAEVVGALSNAVFLTALCFTIFVEAVLRLARPERIDDPELVLIVGVLGLLVNVVG 130

  Fly   129 LCLLYEHGGH-----HGHSHGGGLTRNHSRLTELANMDEG------------EDEQ--------- 167
            |.:..:....     .|.|.         ||.:...:.||            ||.:
Human   131 LLIFQDCAAWFACCLRGRSR---------RLQQRQQLAEGCVPGAFGGPQGAEDPRRAADPTAPG 186

  Fly   168 NDFA-------YEKQKEK-----APVKKSSHGHSHDPGQM----------NMRGAFLHVLSDALG 210
            :|.|       .|:::||     |.|...|....::|..|          |:||..|||:.||||
Human   187 SDSAVTLRGTSVERKREKGATVFANVAGDSFNTQNEPEDMMKKEKKSEALNIRGVLLHVMGDALG 251

  Fly   211 SIIVVISAVVVW----KTE--WKYRYYMDPALSIVLVVLILHSVWPLLRESALILLQTVPTHIQV 269
            |::|||:|::.:    |:|  ..::.|:||:|::::|::||.|.:||::|:|.||||.||..:.:
Human   252 SVVVVITAIIFYVLPLKSEDPCNWQCYIDPSLTVLMVIIILSSAFPLIKETAAILLQMVPKGVNM 316

  Fly   270 DAIQKRLLEKVDGVLAVHEFHVWQLAGDRIIASAHIRCRNLSEYMKIAEKVKEFFHNEGIHSTTI 334
            :.:..: |..|.|:.:|||.|:|:|...:|||:.||:......|...:.|::|.||:.|||:.||
Human   317 EELMSK-LSAVPGISSVHEVHIWELVSGKIIATLHIKYPKDRGYQDASTKIREIFHHAGIHNVTI 380

  Fly   335 QPEFSEIEGCNMSDGTSSINISGSDCCALDCPTTEEGCVKATCC 378
            |  |..::.....:....:.:..|.|.:       :||.|..||
Human   381 Q--FENVDLKEPLEQKDLLLLCNSPCIS-------KGCAKQLCC 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZnT63C	NP_001261364.1	CzcD	10..339	CDD:224151	141/384 (37%)
ZnT63C	NP_001261364.1	Cation_efflux	21..260	CDD:279834	105/294 (36%)
SLC30A10	NP_061183.2	CzcD	10..383	CDD:224151	141/384 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	167..196		4/28 (14%)
		Required for plasma membrane localization. /evidence=ECO:0000269\|PubMed:25319704	308..485		36/118 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152433
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1230
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2578
OMA	1	1.010	-	-		QHG51881
OrthoDB	1	1.010	-	-		D458019at33208
OrthoFinder	1	1.000	-	-		FOG0002109
OrthoInspector	1	1.000	-	-		otm41387
orthoMCL	1	0.900	-	-		OOG6_102585
Panther	1	1.100	-	-	O	PTHR45820
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2014
SonicParanoid	1	1.000	-	-		X1398
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.700