DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZnT63C and slc30a1

DIOPT Version :9

Sequence 1:	NP_001261364.1	Gene:	ZnT63C / 38407	FlyBaseID:	FBgn0035432	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_001007940.1	Gene:	slc30a1 / 493316	XenbaseID:	XB-GENE-484357	Length:	493	Species:	Xenopus tropicalis

Alignment Length:	463	Identity:	186/463 - (40%)
Similarity:	260/463 - (56%)	Gaps:	103/463 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 YSGKKCRLLSMMWLTAFFFFVEIIVGYVTNSMALVADSFHMLGDIAALVISFLSVKMSPKKWS-- 66
            :...:.|||.|:.||..||.||::|..||.|:|:::||||||.|:.|||:..::|:.:.|..|
Frog     2 WESSRVRLLFMLALTFIFFVVEVVVSRVTGSLAMLSDSFHMLSDVIALVVGLVAVRFAQKTRSTD 66

  Fly    67 KNTFGWARAEVLGALVNAVFLVALCFSITIEACKRFIEEEPIHEPELLVIVGALGLLVNVIGLCL 131
            ||||||.||.|:|||||||||.||||:|.:||.:||.|.:.|.:|.:::.|||.|||:|:||||:
Frog    67 KNTFGWIRAGVMGALVNAVFLTALCFTIVLEAIERFTEPQAIEQPLVVMGVGAGGLLINLIGLCM 131

  Fly   132 LYEHGGHHGHSHGG-----GLTRNH----SRLTELANMD--------------------EGEDEQ 167
            ..:..| |||||||     |..::|    ....|.|.:|                    ||...:
Frog   132 FRDSAG-HGHSHGGHGHSHGAKKSHRPRERAAGESAALDREETNILVENCGNSLAAAAAEGMPGK 195

  Fly   168 NDFAYEK---QKEKAPVKKSSHGHSHDPG-QMNMRGAFLHVLSDALGSIIVVISAVVVW------ 222
            :|...|.   .:....|.:::....|:.| |:||||.|||||.|||||:|||::|:|.:
Frog   196 HDALAENIVDGRVNGNVIENNLPEIHEDGTQLNMRGVFLHVLGDALGSVIVVLNALVFYFVFNPC 260

  Fly   223 -----------------------------KTE-----------WKYRYYMDPALSIVLVVLILHS 247
                                         .|.           |.  .|:||:|.:::|.::|::
Frog   261 PSDEGCINPCVEDHCDKKVNVSALSSNPDNTSSPPEIQMAGPCWV--LYLDPSLCVIMVCILLYT 323

  Fly   248 VWPLLRESALILLQTVPTHIQVDAIQKRLLEKVDGVLAVHEFHVWQLAGDRIIASAHIRCRNLSE 312
            .:|||:|||||||||||..|.:.:: |:.|:.:|||.||||.||||||..||||:|||:|.:.:.
Frog   324 TYPLLKESALILLQTVPKQIDISSL-KQKLKNLDGVEAVHELHVWQLAESRIIATAHIKCHDPTA 387

  Fly   313 YMKIAEKVKEFFHNEGIHSTTIQPEFSEIEGCNMSDGTSSINISGS--DCCALDCPTTEEGCVKA 375
            ||.:|:::|:|||:||||:||||||||.:|             |||  ..|.|.|.|.   |...
Frog   388 YMDVAKRIKDFFHDEGIHATTIQPEFSSVE-------------SGSRISLCELSCRTQ---CAPK 436

  Fly   376 TCCQNNNK 383
            .||.:..|
Frog   437 QCCGSTEK 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZnT63C	NP_001261364.1	CzcD	10..339	CDD:224151	172/409 (42%)
ZnT63C	NP_001261364.1	Cation_efflux	21..260	CDD:279834	119/319 (37%)
slc30a1	NP_001007940.1	CzcD	8..415	CDD:224151	173/410 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	173	1.000	Domainoid score	I3657
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H6681
Inparanoid	1	1.050	256	1.000	Inparanoid score	I3078
OMA	1	1.010	-	-		QHG51881
OrthoDB	1	1.010	-	-		D458019at33208
OrthoFinder	1	1.000	-	-		FOG0002109
OrthoInspector	1	1.000	-	-		otm48590
Panther	1	1.100	-	-	O	PTHR45820
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2014
SonicParanoid	1	1.000	-	-		X1398
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.110