DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZnT63C and slc30a5

DIOPT Version :9

Sequence 1:	NP_001261364.1	Gene:	ZnT63C / 38407	FlyBaseID:	FBgn0035432	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_001002322.1	Gene:	slc30a5 / 436594	ZFINID:	ZDB-GENE-040718-6	Length:	775	Species:	Danio rerio

Alignment Length:	391	Identity:	111/391 - (28%)
Similarity:	188/391 - (48%)	Gaps:	88/391 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAKYSGKKCRLLSMMWLTAFFFFVEIIVGYVTNSMALVADSFHMLGDIAALVISFLSVKMSPKKW 65
            :.:|..:  ::...:.|...|.|||:..|..|||:.|::|.||||.|.:|||:...:..|:  :|
Zfish   407 LEEYDSR--QIFYFLCLNLAFTFVELFYGVWTNSLGLISDGFHMLFDCSALVLGLFAALMT--RW 467

  Fly    66 SKN---TFGWARAEVLGALVNAVFLVALCFSITIEACKRFIEEEPIHEPELLVIVGALGLLVNVI 127
            ...   ::|:.|.|:|...:|.:||:.:.|.:.:|:..|.::...|: .::|..|...||:||::
Zfish   468 KATRIYSYGYGRVEILSGFINGLFLMVIAFFVFVESVTRLVDPPNIN-TDMLTPVSVGGLIVNLV 531

  Fly   128 GLCLL---------------YEHG------GH---------HGHSHGGGLTRNHSRLTELANMDE 162
            |:|..               ::||      ||         |||||||   ..||.
Zfish   532 GICAFSHAHSHGASKGSCSGHDHGHSHHGHGHSSMEHSHGGHGHSHGG---HGHSH--------- 584

  Fly   163 GEDEQNDFAYEKQKEKAPVKKSSHGHSHDPGQM--NMRGAFLHVLSDALGSIIVVISAVVVWKTE 225
                                  .|||||..|.|  ||||.|||||:|.|||:.|:||.:::.:..
Zfish   585 ----------------------GHGHSHSSGGMNANMRGVFLHVLADTLGSVGVIISTILIRQFG 627

  Fly   226 WKYRYYMDPALSIVLVVLILHSVWPLLRESALILLQTVPTHIQVD---AIQKRLLEKVDGVLAVH 287
            |   ...||..|:.:..||..||.|||:::..:||..:|...:.:   |::|  ::|::|||:..
Zfish   628 W---LIADPICSLFISTLIFLSVIPLLKDACEVLLLRMPPQHEKELNFALEK--IQKIEGVLSYR 687

  Fly   288 EFHVWQLAGDRIIASAHIRCRNLSEYMKIAEKVKEFFHNEGIHSTTIQPE----FSEIEGCNMSD 348
            :.|.|:.:...|..:.|::..:.....::.::|.....:.|:::.|||.|    |..:.|  :|.
Zfish   688 DPHFWRHSASVIAGTIHLQLMSDVVEQRVIQQVSAVLKDAGVNNLTIQLEKEAYFQHMSG--LSS 750

  Fly   349 G 349
            |
Zfish   751 G 751

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZnT63C	NP_001261364.1	CzcD	10..339	CDD:224151	106/370 (29%)
ZnT63C	NP_001261364.1	Cation_efflux	21..260	CDD:279834	86/273 (32%)
slc30a5	NP_001002322.1	CzcD	411..739	CDD:224151	106/371 (29%)
		Cation_efflux	424..659	CDD:279834	86/274 (31%)
		His-rich loop	538..584		12/48 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	547..592		18/78 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1230
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2014
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840