DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZnT63C and Slc30a10

DIOPT Version :9

Sequence 1:	NP_001261364.1	Gene:	ZnT63C / 38407	FlyBaseID:	FBgn0035432	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_001099455.1	Gene:	Slc30a10 / 289353	RGDID:	1305098	Length:	472	Species:	Rattus norvegicus

Alignment Length:	424	Identity:	162/424 - (38%)
Similarity:	241/424 - (56%)	Gaps:	63/424 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAKYSGKKCRLLSMMWLTAFFFFVEIIVGYVTNSMALVADSFHMLGDIAALVISFLS---VKMSP 62
            |.:||||.||||.|:.|||.||..|::.||:.||:||::|||:||.|:.:|.:...|   .:..|
  Rat     1 MGRYSGKTCRLLFMLVLTAAFFVAELVSGYLGNSIALLSDSFNMLSDLISLCVGLGSGYIARRGP 65

  Fly    63 KKWSKNTFGWARAEVLGALVNAVFLVALCFSITIEACKRFIEEEPIHEPELLVIVGALGLLVNVI 127
             :.|..|:|:.||||:|||.|||||.||||:|.:||..|....|.|.:|||::|||||||.|||:
  Rat    66 -RGSSATYGYVRAEVVGALSNAVFLTALCFTIFVEAVLRLARPERIDDPELVLIVGALGLAVNVV 129

  Fly   128 GLCLLYEHG--------GH---------HGHSHGG-GLTRNHSRLTELANMDEGEDE----QNDF 170
            ||.:..:.|        ||         .|.:.|. |..|..:..|     |.|.|.    :...
  Rat   130 GLLIFQDCGACFSRCTRGHRTRPSQPPRQGDTGGALGCPREAATAT-----DPGSDSAVTLRGAS 189

  Fly   171 AYEKQKEKAPVKKSSHGHS----HDPGQ----------MNMRGAFLHVLSDALGSIIVVISAVVV 221
            |..||:|.|.|..:..|.|    ::|.:          :|:||..|||:.|||||:|||::|::.
  Rat   190 AGRKQQEGATVFSNVAGDSLNTQNEPEETTKKEKKSEALNIRGVLLHVMGDALGSVIVVVTAIIF 254

  Fly   222 W------KTEWKYRYYMDPALSIVLVVLILHSVWPLLRESALILLQTVPTHIQVDAIQKRLLEKV 280
            :      :....::.|:||:|::|:|::||.|.:||::|:|:||||.||..:.::.:..: |..|
  Rat   255 YVRPLRHEDPCNWQCYIDPSLTVVMVIIILSSAFPLIKETAVILLQMVPKGVNMEELMSQ-LSMV 318

  Fly   281 DGVLAVHEFHVWQLAGDRIIASAHIRCRNLSEYMKIAEKVKEFFHNEGIHSTTIQPEFSEI-EGC 344
            .||.:|||.|:|:|...::||:.||:.:..:||...:.||:|.||:.|||:.|||.|..:: |..
  Rat   319 PGVSSVHEVHIWELISGKVIATLHIKHQEGTEYQDASRKVREIFHHAGIHNVTIQFETLDLKEAL 383

  Fly   345 NMSDGTSSINISGSDCCALDCPTTEEGCVKATCC 378
            ...|...:       |.|   |...:.|.|..||
  Rat   384 EQKDFLPT-------CSA---PCISQSCAKKLCC 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZnT63C	NP_001261364.1	CzcD	10..339	CDD:224151	147/373 (39%)
ZnT63C	NP_001261364.1	Cation_efflux	21..260	CDD:279834	107/283 (38%)
Slc30a10	NP_001099455.1	CzcD	10..376	CDD:224151	146/372 (39%)
Slc30a10	NP_001099455.1	Cation_efflux	20..299	CDD:279834	107/284 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345948
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1230
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51881
OrthoDB	1	1.010	-	-		D458019at33208
OrthoFinder	1	1.000	-	-		FOG0002109
OrthoInspector	1	1.000	-	-		otm45504
orthoMCL	1	0.900	-	-		OOG6_102585
Panther	1	1.100	-	-	O	PTHR45820
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1398
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.720