DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZnT63C and zhf1

DIOPT Version :9

Sequence 1:	NP_001261364.1	Gene:	ZnT63C / 38407	FlyBaseID:	FBgn0035432	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_593645.1	Gene:	zhf1 / 2542060	PomBaseID:	SPAC23C11.14	Length:	387	Species:	Schizosaccharomyces pombe

Alignment Length:	375	Identity:	138/375 - (36%)
Similarity:	211/375 - (56%)	Gaps:	47/375 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KKCRLLSMMWLTAFFFFVEIIVGYVTNSMALVADSFHMLGDIAALVISFLSVKM--SPKKWSKNT 69
            ::.|::.::.:...|||:|||.||..:|:||:|||||||.||.:|:::..:.::  |.....|.|
pombe     6 RQTRIILLLGIDVTFFFIEIITGYAIDSLALIADSFHMLNDIVSLLVALWATRLAHSTSHEPKYT 70

  Fly    70 FGWARAEVLGALVNAVFLVALCFSITIEACKRFIEEEPIHEPELLVIVGALGLLVNVIGLCLLYE 134
            :||.|||:||||.|.|||:|||..|.:||.:||||...:..|.|:..||:||||.|.:|:.|.::
pombe    71 YGWQRAEILGALSNGVFLIALCMFIFMEAIERFIEPPSVSNPTLMFFVGSLGLLSNFVGIFLFHD 135

  Fly   135 HGGHHGHSHGGGLTRNH-------------SRLTELANMDEGE---------DEQND----FAYE 173
            ||..|.|:|   ..:|:             |.:....|..:.|         |...:    .:|.
pombe   136 HGHDHPHTH---TAQNYDFPEEDDIESVLPSTIVHRCNTSQQEVSHTHTQVADSATESSPLLSYT 197

  Fly   174 KQKEKAPVKK--SSHG--HSHDPGQ-----MNMRGAFLHVLSDALGSIIVVISAVVVWKTEWKYR 229
            .....|...|  ::||  ....|.|     :||.|.|||||.||||:|.|:.:|:.:..|::.:|
pombe   198 GNHNGAGTSKPVNNHGSIEQDAPKQTKKRNLNMHGVFLHVLGDALGNIGVISAALFIKYTDYSWR 262

  Fly   230 YYMDPALSIVLVVLILHSVWPLLRESALILLQTVPTHIQVDAIQKRLLEKVDGVLAVHEFHVWQL 294
            :..||.:||:|..:||.|..||.:.:||||||..|..|::|.: ..|:..:|||.:|||.|:|||
pombe   263 FLFDPCISILLTFIILFSAIPLCKSAALILLQVAPQSIKLDDV-SNLINHLDGVESVHELHIWQL 326

  Fly   295 AGDRIIASAHIRCRNLSE-----YMKIAEKVKEFFHNEGIHSTTIQPEFS 339
            :..::||:.|: |..|.:     |.|:...::....:.||:..||||||:
pombe   327 SDVKLIATVHV-CVTLPDDKGESYTKLTTDIRNVLQSFGIYDVTIQPEFA 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZnT63C	NP_001261364.1	CzcD	10..339	CDD:224151	137/370 (37%)
ZnT63C	NP_001261364.1	Cation_efflux	21..260	CDD:279834	105/275 (38%)
zhf1	NP_593645.1	CzcD	1..377	CDD:224151	138/375 (37%)
zhf1	NP_593645.1	Cation_efflux	19..293	CDD:279834	105/276 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	176	1.000	Domainoid score	I849
eggNOG	1	0.900	-	-		E1_COG1230
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6681
Inparanoid	1	1.050	234	1.000	Inparanoid score	I845
OMA	1	1.010	-	-		QHG51881
OrthoFinder	1	1.000	-	-		FOG0002109
OrthoInspector	1	1.000	-	-		oto101301
orthoMCL	1	0.900	-	-		OOG6_102585
Panther	1	1.100	-	-	O	PTHR45820
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2014
SonicParanoid	1	1.000	-	-		X1398
TreeFam	1	0.960	-	-
	14	13.860