DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZnT63C and Slc30a3

DIOPT Version :9

Sequence 1:	NP_001261364.1	Gene:	ZnT63C / 38407	FlyBaseID:	FBgn0035432	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_035903.2	Gene:	Slc30a3 / 22784	MGIID:	1345280	Length:	388	Species:	Mus musculus

Alignment Length:	334	Identity:	88/334 - (26%)
Similarity:	162/334 - (48%)	Gaps:	45/334 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 FFFV--EIIVGYVTNSMALVADSFHMLGDIAALVISFLSVKMSPKKWSKN-TFGWARAEVLGALV 82
            |.|:  |::.||:.:|:|::.|:.|:|.||.:::.|..|:.:|.:..::. ||||.|:|.||||.
Mouse    84 FIFMAGEVVGGYLAHSLAIMTDAAHLLADIGSMLASLFSLWLSTRPATRTMTFGWHRSETLGALA 148

  Fly    83 NAVFLVALCFSITIEACKRFIEEEPIHEPELLVIVGALGLLVNVIGLCLLYEHGGHHGHSHGGGL 147
            :.|.|..:...:...|..|.:..:...|...:::..::.:..|::...:|::.|..|.|...|
Mouse   149 SVVSLWIVTGILLYLAFLRLLHSDYHIEAGAMLLTASIAVCANLLMAFVLHQTGAPHSHGSTG-- 211

  Fly   148 TRNHSRLTELANMDEGEDEQNDFAYEKQKEKAPVKKSSHGHSHDPGQMNMRGAFLHVLSDALGSI 212
                   .|.|.::||                      ||:....|..::|.||:|||.|.|.|.
Mouse   212 -------AEYAPLEEG----------------------HGYPMSLGNTSVRAAFVHVLGDLLQSF 247

  Fly   213 IVVISAVVVW-KTEWKYRYYMDPALSIVLVVLILHSVWPLLRESALILLQTVPTHIQVDAIQKRL 276
            .|:.:::::: |.::|   ..||..:.:..:..|.|..|.||:..|:|::..|..::.:.::..|
Mouse   248 GVLAASILIYFKPQYK---VADPISTFLFSICALGSTAPTLRDVLLVLMEGAPRSVEFEPVRDTL 309

  Fly   277 LEKVDGVLAVHEFHVWQLAGDRIIASAHIRCRNLSE-YMKIAEKVKEFFHNEGIHSTTI-----Q 335
            | .|.||.|.|:.|:|.|.....:||||:...:.:: ...:||.....:...|..|.|:     |
Mouse   310 L-SVPGVRATHDLHLWALTLTYHVASAHLAIDSTADPEAVLAEASSRLYSRFGFSSCTLQVEQYQ 373

  Fly   336 PEFSEIEGC 344
            ||.::...|
Mouse   374 PEMAQCLRC 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZnT63C	NP_001261364.1	CzcD	10..339	CDD:224151	87/327 (27%)
ZnT63C	NP_001261364.1	Cation_efflux	21..260	CDD:279834	63/242 (26%)
Slc30a3	NP_035903.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41
		CDF	85..372	CDD:273544	83/321 (26%)
		Cation_efflux	85..293	CDD:279834	62/241 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842493
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1230
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740