DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZnT63C and Slc30a10

DIOPT Version :9

Sequence 1:	NP_001261364.1	Gene:	ZnT63C / 38407	FlyBaseID:	FBgn0035432	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_001028458.1	Gene:	Slc30a10 / 226781	MGIID:	2685058	Length:	470	Species:	Mus musculus

Alignment Length:	511	Identity:	172/511 - (33%)
Similarity:	257/511 - (50%)	Gaps:	90/511 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAKYSGKKCRLLSMMWLTAFFFFVEIIVGYVTNSMALVADSFHMLGDIAALVISFLS---VKMSP 62
            |.:||||.||||.|:.|||.||..|::.||:.||:||::|||:||.|:.:|.:...|   .:..|
Mouse     1 MGRYSGKTCRLLFMLVLTAAFFVAELVSGYLGNSIALLSDSFNMLSDLISLCVGLGSGYIARRGP 65

  Fly    63 KKWSKNTFGWARAEVLGALVNAVFLVALCFSITIEACKRFIEEEPIHEPELLVIVGALGLLVNVI 127
             :.|..|:|:.||||:|||.|||||.||||:|.:||..|....|.|.:|||::|||||||.|||:
Mouse    66 -RGSSATYGYVRAEVVGALSNAVFLTALCFTIFVEAVLRLARPERIDDPELVLIVGALGLAVNVV 129

  Fly   128 GLCLLYEHGGHHGHSHGGGLTRNHSRLTE------LANMDEGEDE-----------QNDFAYEKQ 175
            ||.:..:.|........|..||...:.::      |....|....           :...|..||
Mouse   130 GLLIFQDCGACFSRCTRGRRTRPSQQPSQGDPRGALGCPQEAATATAPGSGTAVTLRGSSAGRKQ 194

  Fly   176 KEKAPVKKSSHGHS----HDPGQ----------MNMRGAFLHVLSDALGSIIVVISAVVVW---- 222
            :|.|.|..:..|.|    ::|.:          :|:||..|||:.|||||::|||:|::.:
Mouse   195 QEGATVFSNVAGDSLNTENEPEETTKKEKKSEALNIRGVLLHVMGDALGSVVVVITAIIFYVQPL 259

  Fly   223 --KTEWKYRYYMDPALSIVLVVLILHSVWPLLRESALILLQTVPTHIQVDAIQKRLLEKVDGVLA 285
              :....::.|:||:|::|:|::||.|.:||::|:|:||||.||..:.::.:..: |..|.|:.:
Mouse   260 RREDPCNWQCYIDPSLTVVMVIIILSSAFPLIKETAVILLQMVPKGVNMEELMSQ-LSTVPGISS 323

  Fly   286 VHEFHVWQLAGDRIIASAHIRCRNLSEYMKIAEKVKEFFHNEGIHSTTIQPEFSEI-EGCNMSDG 349
            |||.|:|:|...:|||:.||:.:..:||...:.|::|.||:.|||:.|||.|..:: |.....|.
Mouse   324 VHEVHIWELISGKIIATLHIKHQKGTEYQDASRKIREIFHHAGIHNVTIQFETLDLKEALEQKDF 388

  Fly   350 TSSINISGSDCCALDCPTTEEGCVKATCCQNNNKLNQLPSPTNSPYL----CRQRNAARQAGDVE 410
            ..:        |:..|.|  :.|.|..||          .|...|..    |.:.|
Mouse   389 LLT--------CSAPCIT--QSCAKKLCC----------PPGTLPLALVNGCAEHN--------- 424

  Fly   411 AGSLLEATSSGNQGATGGASTGAPVAAIGATSTPKSDLVXRQPHQAQQH----VHF 462
                      |........|..||..||.....|:.........|.:||    .||
Mouse   425 ----------GRSSRESYRSIEAPEVAIDVDGCPREQGQTLSKTQERQHYENSTHF 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZnT63C	NP_001261364.1	CzcD	10..339	CDD:224151	141/368 (38%)
ZnT63C	NP_001261364.1	Cation_efflux	21..260	CDD:279834	102/278 (37%)
Slc30a10	NP_001028458.1	CzcD	10..376	CDD:224151	140/367 (38%)
		Cation_efflux	20..299	CDD:279834	102/279 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	146..223		14/76 (18%)
		Required for plasma membrane localization. /evidence=ECO:0000250\|UniProtKB:Q6XR72	300..470		53/209 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	451..470		3/18 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842498
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1230
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2578
OMA	1	1.010	-	-		QHG51881
OrthoDB	1	1.010	-	-		D458019at33208
OrthoFinder	1	1.000	-	-		FOG0002109
OrthoInspector	1	1.000	-	-		otm43442
orthoMCL	1	0.900	-	-		OOG6_102585
Panther	1	1.100	-	-	O	PTHR45820
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2014
SonicParanoid	1	1.000	-	-		X1398
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.700