DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZnT63C and Slc30a6

DIOPT Version :9

Sequence 1:	NP_001261364.1	Gene:	ZnT63C / 38407	FlyBaseID:	FBgn0035432	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_001239407.1	Gene:	Slc30a6 / 210148	MGIID:	2386741	Length:	465	Species:	Mus musculus

Alignment Length:	333	Identity:	82/333 - (24%)
Similarity:	135/333 - (40%)	Gaps:	81/333 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 CRLLSMMWLTAFFFFVEIIVGYVTNSMALVADSFHMLGDIAAL--------VISFLSVKMSPKKW 65
            |....:||.::            |||:||.|.::..:.|:.:|        :||:..:...|.
Mouse    44 CTGFLLMWCSS------------TNSIALTAYTYLTIFDLFSLFFFSLITCLISYWVMMRKPS-- 94

  Fly    66 SKNTFGWARAEVLGALVNAVFLVALCFSITIEACKRFIEEEPIHEPELLVIVGALGLLVNVIGLC 130
            ...:||:.|.|||....:.|........|..|:.:||:|:..||...|||     |..|
Mouse    95 PVYSFGFERLEVLAVFASTVLAQLGALFILKESAERFLEQPEIHTGRLLV-----GTFV------ 148

  Fly   131 LLYEHGGHHGHSHGGGLTRNHSRLTELANMDEGEDEQNDFAYEK--------QKEKAPVKKSSHG 187
                           .|:.|...:..:.|        ..|||..        |:..|.:.:|..|
Mouse   149 ---------------ALSFNLFTMLSIRN--------KPFAYVSEAASTSWLQEHVADLSRSLCG 190

  Fly   188 HSHDPGQMNMRGAFL-----HVLSDALGSIIVVISAVVVWKTEWKYRYYMDPALSIVLVVLILHS 247
            ..  ||   :...||     .||.|..|:..:.|:.:::   |....:.:|.|.:|.:.::...:
Mouse   191 LI--PG---LSSIFLPRMNPFVLIDLAGAFALCITYMLI---EINNYFAVDTASAIAIALMTFGT 247

  Fly   248 VWPLLRESALILLQTVPTHI--QVDAIQKRLLEKVDGVLAVHEFHVWQLAGDRIIASAHIRC-RN 309
            ::|:...|..:||||.|.|:  |:|.: .|.:..:||||.|...|.|.|....:..|.|:|. |:
Mouse   248 MYPMSVYSGKVLLQTTPPHVIGQLDKL-IREVSTLDGVLEVRNEHFWTLGFGSLAGSVHVRIRRD 311

  Fly   310 LSEYMKIA 317
            .:|.|.:|
Mouse   312 ANEQMVLA 319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZnT63C	NP_001261364.1	CzcD	10..339	CDD:224151	81/332 (24%)
ZnT63C	NP_001261364.1	Cation_efflux	21..260	CDD:279834	55/259 (21%)
Slc30a6	NP_001239407.1	Cation_efflux	43..260	CDD:279834	58/271 (21%)
		CzcD	<83..336	CDD:224151	71/282 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	376..395
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1230
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810