DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZnT63C and cdf-1

DIOPT Version :9

Sequence 1:	NP_001261364.1	Gene:	ZnT63C / 38407	FlyBaseID:	FBgn0035432	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_509096.2	Gene:	cdf-1 / 180923	WormBaseID:	WBGene00000393	Length:	586	Species:	Caenorhabditis elegans

Alignment Length:	445	Identity:	131/445 - (29%)
Similarity:	204/445 - (45%)	Gaps:	115/445 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LLSMMWLTAFFFFVEIIVGYVTNSMALVADSFHMLGDIAALVISFLSVKMSPKKWSKNTFGWARA 75
            |:..:.:|..|..:|.|.|.|.:|:|::|||:||..|:.||:::|..:|::.:..::..:||.||
Worm   138 LIIQIGMTVIFCALEFITGVVCSSIAMLADSYHMAADVMALIVAFTCIKIATRPSTRLGYGWVRA 202

  Fly    76 EVLGALVNAVFLVALCFSITIEACKRFIEEEPIHEPELLVIVGALGLLVNVIGLCLLYEH----- 135
            |.||...|.:|:..:|..:..||..|.|....|..|..::::|.:|||:|:.|:..|..|
Worm   203 ETLGGFFNGIFMCTVCVLVFQEAVGRIINVHMITHPLQVLVIGFIGLLINLFGMFNLSGHGHSHG 267

  Fly   136 GGHHGHSHGG--GLTRN-----------------------------------HSRL-------TE 156
            ||.|||||||  |.:.|                                   |:||       :.
Worm   268 GGSHGHSHGGSHGHSHNNKKTKKNDGHGHSHANGHGHSHDGKSDCNGEEEPDHTRLNGKFRSASA 332

  Fly   157 LANMD------EGEDEQNDFA---------------------------------------YEKQK 176
            :||.|      :.:|..||..                                       .:|..
Worm   333 MANSDANVRLLDNDDNSNDIIERRLSGVNSQNTIIATVDRQMTPYGTHMASEVLNVSSNNLDKSA 397

  Fly   177 EKAPVKKSSHGHSHDPGQMNMRGAFLHVLSDALGSIIVVISA-VVVWKTEWKYRYYMDPALSIVL 240
            :|...||..:        :|:.|.:||:||||.||:||:||| .|.:...||...|:||.|||.|
Worm   398 QKTEQKKDKN--------VNIHGVWLHLLSDAFGSVIVMISAGFVYFLPTWKIAAYLDPILSISL 454

  Fly   241 VVLILHSVWPLLRESALILLQTVPTHIQVDAIQKRLLEKVDGVLAVHEFHVWQLAGDRIIASAHI 305
            ..::..:...|::.|...||:..|..:.::.::|.|...| ||..|.:..||.|.|.||||:||:
Worm   455 ASIMGFTAVVLVKTSGEKLLKQTPEGLDLEKVKKDLCSIV-GVSKVEKLSVWTLCGQRIIAAAHV 518

  Fly   306 RCRNLSEYMKIAEKVKEFFHNEGIHSTTIQPEFSEIEGCNMS---------DGTS 351
            ...:.:.:.:.|.|:|.:||:.|:|||||:|.|.:.  |..|         ||.|
Worm   519 NICHPAVFPEAAYKIKNYFHDLGVHSTTIEPTFEDT--CMQSMRIMVKKVVDGKS 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZnT63C	NP_001261364.1	CzcD	10..339	CDD:224151	125/422 (30%)
ZnT63C	NP_001261364.1	Cation_efflux	21..260	CDD:279834	92/333 (28%)
cdf-1	NP_509096.2	CzcD	135..552	CDD:224151	125/422 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	181	1.000	Inparanoid score	I2663
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51881
OrthoDB	1	1.010	-	-		D458019at33208
OrthoFinder	1	1.000	-	-		FOG0002109
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102585
Panther	1	1.100	-	-	O	PTHR45820
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2014
SonicParanoid	1	1.000	-	-		X1398
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.010