DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZnT63C and SLC30A7

DIOPT Version :9

Sequence 1:	NP_001261364.1	Gene:	ZnT63C / 38407	FlyBaseID:	FBgn0035432	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_001138356.1	Gene:	SLC30A7 / 148867	HGNCID:	19306	Length:	376	Species:	Homo sapiens

Alignment Length:	353	Identity:	113/353 - (32%)
Similarity:	181/353 - (51%)	Gaps:	27/353 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SGKKCR-LLSMMWLTAFFFFVEIIVGYVTNSMALVADSFHMLGDIAALVISFLSVKMSPKKWSKN 68
            |.|..| |...:.|...|.|||::.|..:|.:.|::|||||..|..|::....:..:|  ||..|
Human    31 SDKTSRNLFFFLCLNLSFAFVELLYGIWSNCLGLISDSFHMFFDSTAILAGLAASVIS--KWRDN 93

  Fly    69 ---TFGWARAEVLGALVNAVFLVALCFSITIEACKRFIEEEPIHEPELLVIVGALGLLVNVIGLC 130
               ::|:.|||||...||.:||:...|.|..|..:|.:....:|. |.|::|..||.:||:||:
Human    94 DAFSYGYVRAEVLAGFVNGLFLIFTAFFIFSEGVERALAPPDVHH-ERLLLVSILGFVVNLIGI- 156

  Fly   131 LLYEHGGHHGHSHGGGLTRNHSRLTELANMDEGEDEQNDFAYEKQKEKAPVKKSSHG----HSHD 191
            .:::||| ||||||.|...:||......:...|..: :..::|.:...|.....:||    ||||
Human   157 FVFKHGG-HGHSHGSGHGHSHSLFNGALDQAHGHVD-HCHSHEVKHGAAHSHDHAHGHGHFHSHD 219

  Fly   192 ---------PGQMNMRGAFLHVLSDALGSIIVVISAVVVWKTEWKYRYYMDPALSIVLVVLILHS 247
                     |.:..::|.|||:|:|.||||.|:.||:::....   ....||..||::.:||:.|
Human   220 GPSLKETTGPSRQILQGVFLHILADTLGSIGVIASAIMMQNFG---LMIADPICSILIAILIVVS 281

  Fly   248 VWPLLRESALILLQTVPTHIQVDAIQ-KRLLEKVDGVLAVHEFHVWQLAGDRIIASAHIRCRNLS 311
            |.||||||..||:|..|..::....| .:.::::.||.::.|.|.|.|..|..:.:..:.....:
Human   282 VIPLLRESVGILMQRTPPLLENSLPQCYQRVQQLQGVYSLQEQHFWTLCSDVYVGTLKLIVAPDA 346

  Fly   312 EYMKIAEKVKEFFHNEGIHSTTIQPEFS 339
            :...|..:....|...|:....:|.:|:
Human   347 DARWILSQTHNIFTQAGVRQLYVQIDFA 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZnT63C	NP_001261364.1	CzcD	10..339	CDD:224151	110/346 (32%)
ZnT63C	NP_001261364.1	Cation_efflux	21..260	CDD:279834	92/254 (36%)
SLC30A7	NP_001138356.1	CzcD	31..374	CDD:224151	112/351 (32%)
		Cation_efflux	48..294	CDD:279834	92/254 (36%)
		His-rich loop	161..218		18/58 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	194..226		8/31 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1230
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51881
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2014
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850