DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZnT63C and slc30a1b

DIOPT Version :9

Sequence 1:	NP_001261364.1	Gene:	ZnT63C / 38407	FlyBaseID:	FBgn0035432	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_001083052.2	Gene:	slc30a1b / 100038803	ZFINID:	ZDB-GENE-070424-43	Length:	475	Species:	Danio rerio

Alignment Length:	461	Identity:	177/461 - (38%)
Similarity:	253/461 - (54%)	Gaps:	91/461 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 KCRLLSMMWLTAFFFFVEIIVGYVTNSMALVADSFHMLGDIAALVISFLSVKM--SPKKWSKNTF 70
            :.|||.|:.||..||.||::|..:|.|:|:::||||||.|:.||.::.::|..  :.:..||||:
Zfish     7 RMRLLCMLTLTLVFFVVEVVVSRITASLAMLSDSFHMLSDVIALTVALIAVSFAETTRSTSKNTY 71

  Fly    71 GWARAEVLGALVNAVFLVALCFSITIEACKRFIEEEPIHEPELLVIVGALGLLVNVIGLCLLYEH 135
            ||.||||:|||||||||.||||:|.:||.:|:.:...|..|.:::.||..||||||:||.|.:.|
Zfish    72 GWIRAEVMGALVNAVFLTALCFTIFLEAVERYTQPHEIENPRVVIWVGVAGLLVNVLGLFLFHGH 136

  Fly   136 GGH--HGHSHGGGLTRNHSRLTELANMDEGE-----------DEQNDFAYEKQKEKAPVKKSSHG 187
            .|.  |||:|||.....||...:..:.::.:           ..|.|...|::.:...::.::.|
Zfish   137 AGFGGHGHAHGGHSHAGHSHAHQTNHREKPKAHEEACTLMINSSQGDHTCEQKSDSLNIRITAKG 201

  Fly   188 HSHD-------PGQMNMRGAFLHVLSDALGSIIVVISAVV---VW-------------------- 222
            ...|       ..|:||||.|||||.||||||:||::|::   ||
Zfish   202 SLEDLDQSPESASQLNMRGVFLHVLGDALGSIVVVVNALIFTFVWTPCHSDQICYNPCRNNHLTD 266

  Fly   223 ------------KTE-------------WKYRYYMDPALSIVLVVLILHSVWPLLRESALILLQT 262
                        ||.             |.  .|:||.|.:::|.::|::.:|||:|||||||||
Zfish   267 HHHVNTTVLSISKTPDRIPRTISVAGPCWV--LYLDPTLCLIMVCILLYTTFPLLKESALILLQT 329

  Fly   263 VPTHIQVDAIQKRLLEKVDGVLAVHEFHVWQLAGDRIIASAHIRCRNLSEYMKIAEKVKEFFHNE 327
            ||..|.:..: |..|:.:|||||||:.|:|||||.||||:|||:|.:.:.||.||:::|:.||:|
Zfish   330 VPEQIDMPKL-KGKLKSLDGVLAVHDLHIWQLAGARIIATAHIKCTDPALYMDIAKRIKDVFHDE 393

  Fly   328 GIHSTTIQPEFSEIEGCNMSDGTSSINISGSDCCALDCPTTEEGCVKATCCQNNNKLNQLPSPTN 392
            |||:||:|||||.     .|:|      .|...|.|.|   ...|....||....:    ..|..
Zfish   394 GIHATTVQPEFSA-----FSEG------FGDPQCELSC---RSQCKPKLCCNPTKR----AKPEE 440

  Fly   393 SPYLCR 398
            ....||
Zfish   441 ELAKCR 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZnT63C	NP_001261364.1	CzcD	10..339	CDD:224151	163/398 (41%)
ZnT63C	NP_001261364.1	Cation_efflux	21..260	CDD:279834	111/308 (36%)
slc30a1b	NP_001083052.2	CDF	30..403	CDD:273544	150/375 (40%)
slc30a1b	NP_001083052.2	Cation_efflux	30..327	CDD:279834	106/298 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	205	1.000	Domainoid score	I2889
eggNOG	1	0.900	-	-		E1_COG1230
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	314	1.000	Inparanoid score	I2549
OMA	1	1.010	-	-		QHG51881
OrthoDB	1	1.010	-	-		D458019at33208
OrthoFinder	1	1.000	-	-		FOG0002109
OrthoInspector	1	1.000	-	-		otm26448
orthoMCL	1	0.900	-	-		OOG6_102585
Panther	1	1.100	-	-	O	PTHR45820
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2014
SonicParanoid	1	1.000	-	-		X1398
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.910