DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14968 and Appl2

DIOPT Version :9

Sequence 1:	NP_647800.1	Gene:	CG14968 / 38406	FlyBaseID:	FBgn0035431	Length:	199	Species:	Drosophila melanogaster
Sequence 2:	NP_001102211.1	Gene:	Appl2 / 362860	RGDID:	1563028	Length:	662	Species:	Rattus norvegicus

Alignment Length:	218	Identity:	45/218 - (20%)
Similarity:	69/218 - (31%)	Gaps:	85/218 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 VDIMVGVAKNLPPNKVLPNCELKVSTDGVQLEIISPKAS----------INHW------SYPIDT 95
            |.|:...|.::|..:     ||......:|.:|:.|...          ||.:      |:| |.
  Rat   425 VKIVPKAAASIPETE-----ELIAPGTPIQFDIVLPATEFLDQNRGSRRINPFGETEDDSFP-DA 483

  Fly    96 ISYGVQDLVYTRVFAMIVVKDESSPHPF--------------------EVHAFV-------CDSR 133
            ....:|.:...|....:.||.:|:....                    |.|..|       .|.:
  Rat   484 EDSLLQQMFIVRFLGSMAVKTDSTTEVIYEAMRQVLAARAIHNIFRTTESHLMVTSQTLRLIDPQ 548

  Fly   134 AMARKLTFALA-----AAFQDYSR------RVKEATGEE-----------EGEATPSDTITPTRH 176
            ....:..|.|.     ||.|:..|      ||.|:||||           |||
  Rat   549 TQVSRACFELTSVTQFAAHQENKRLVGFVIRVPESTGEESLSTYIFESNSEGE------------ 601

  Fly   177 KFAIDLRTPEEIQAGELEQETEA 199
            |....:...:||.  |::::.||
  Rat   602 KICYAINLGKEII--EVQKDPEA 622

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14968	NP_647800.1	PTB_LDLRAP_insect-like	23..147	CDD:269982	26/147 (18%)
Appl2	NP_001102211.1	BAR_APPL2	20..234	CDD:153316
		BAR-PH_APPL	252..376	CDD:270067
		PTB_APPL	480..613	CDD:269980	28/145 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	643..662
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3536
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900