DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14968 and LDLRAP1

DIOPT Version :9

Sequence 1:	NP_647800.1	Gene:	CG14968 / 38406	FlyBaseID:	FBgn0035431	Length:	199	Species:	Drosophila melanogaster
Sequence 2:	NP_056442.2	Gene:	LDLRAP1 / 26119	HGNCID:	18640	Length:	308	Species:	Homo sapiens

Alignment Length:	163	Identity:	49/163 - (30%)
Similarity:	69/163 - (42%)	Gaps:	26/163 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 FKVKYIGSEVARGLWGIKYTRRPVDIMVGVAKNLPPNKVLPNCELKVSTDGVQLEIISPKASINH 88
            |.:||:|..:.....|.:.:...:..:|..||  ...|.|....||||..|:.|........|.:
Human    48 FSLKYLGMTLVEQPKGEELSAAAIKRIVATAK--ASGKKLQKVTLKVSPRGIILTDNLTNQLIEN 110

  Fly    89 WSYPIDTISYGVQDLVYTRVFAMIVVKDESSPH--PFEVHAFVCDSRAMARKLTFALAAAFQ--- 148
            .|  |..|||...|.::.:|||.|.    .|.|  ..|.|||:|..|.||:.:|..:|.||:
Human   111 VS--IYRISYCTADKMHDKVFAYIA----QSQHNQSLECHAFLCTKRKMAQAVTLTVAQAFKVAF 169

  Fly   149 ---DYSRRVKEA--TGEEEG--------EATPS 168
               ..|:..||.  ...:||        :.|||
Human   170 EFWQVSKEEKEKRDKASQEGGDVLGARQDCTPS 202

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14968	NP_647800.1	PTB_LDLRAP_insect-like	23..147	CDD:269982	39/124 (31%)
LDLRAP1	NP_056442.2	PTB_LDLRAP-mammal-like	44..166	CDD:269981	40/125 (32%)
		Clathrin box. /evidence=ECO:0000269\|PubMed:12221107	212..216
		AP-2 complex binding. /evidence=ECO:0000269\|PubMed:12221107	249..276
		[DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif. /evidence=ECO:0000269\|PubMed:16516836	257..266
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3536
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810