DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14968 and Ldlrap1

DIOPT Version :9

Sequence 1:	NP_647800.1	Gene:	CG14968 / 38406	FlyBaseID:	FBgn0035431	Length:	199	Species:	Drosophila melanogaster
Sequence 2:	NP_663529.2	Gene:	Ldlrap1 / 100017	MGIID:	2140175	Length:	308	Species:	Mus musculus

Alignment Length:	189	Identity:	54/189 - (28%)
Similarity:	82/189 - (43%)	Gaps:	28/189 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 ITFKVKYIGSEVARGLWGIKYTRRPVDIMVGVAKNLPPNKVLPNCELKVSTDGVQLEIISPKASI 86
            :.|.:||:|..:.....|.:.:...|..:|..||  ...|.|....||||..|:.|........|
Mouse    45 MVFSLKYLGMTLVERPKGEELSAAAVKRIVATAK--ASGKKLQKVTLKVSPRGIILTDSLTSQLI 107

  Fly    87 NHWSYPIDTISYGVQDLVYTRVFAMIVVKDESSPHPFEVHAFVCDSRAMARKLTFALAAAFQ--- 148
            .:.|  |..|||...|.::.:|||.|....::  ...|.|||:|..|.:|:.:|..:|.||:
Mouse   108 ENVS--IYRISYCTADKMHDKVFAYIAQSQQN--ESLECHAFLCTKRKVAQAVTLTVAQAFKVAF 168

  Fly   149 ---DYSRRVKE--ATGEEEG--------EATPS-DTITPTRHKFAIDLRTPEEIQAGEL 193
               ..|:..||  ....:||        ::||| .|:..|.:  .:||   ||:....|
Mouse   169 EFWQVSKEEKEKREKANQEGGDVPGTRRDSTPSLKTLVATGN--LLDL---EEVAKAPL 222

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14968	NP_647800.1	PTB_LDLRAP_insect-like	23..147	CDD:269982	37/123 (30%)
Ldlrap1	NP_663529.2	PTB_LDLRAP-mammal-like	43..165	CDD:269981	38/125 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	179..201		4/21 (19%)
		Clathrin box. /evidence=ECO:0000250\|UniProtKB:Q5SW96	211..215		2/6 (33%)
		AP-2 complex binding. /evidence=ECO:0000250\|UniProtKB:Q5SW96	248..275
		[DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif. /evidence=ECO:0000250\|UniProtKB:Q5SW96	256..265
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	288..308
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3536
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	49	1.000	Inparanoid score	I5474
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.860