DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17746 and Tab1

DIOPT Version :9

Sequence 1:	NP_647794.1	Gene:	CG17746 / 38400	FlyBaseID:	FBgn0035425	Length:	371	Species:	Drosophila melanogaster
Sequence 2:	NP_079885.2	Gene:	Tab1 / 66513	MGIID:	1913763	Length:	502	Species:	Mus musculus

Alignment Length:	318	Identity:	68/318 - (21%)
Similarity:	124/318 - (38%)	Gaps:	84/318 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 QTLSEPVTAKESAYCQNAAYRVGSSCMQGWRINMEDSHTHILSLPDDPGAAF--------FAVYD 59
            |:..:|....:...|..:.  |||:..:.:..:.:.:.:|   .|:|....|        :.|::
Mouse    10 QSEQQPSWTDDLPLCHLSG--VGSASNRSYSADGKGTESH---PPEDNWLKFRSENNCFLYGVFN 69

  Fly    60 GHGGATVAQYAGKHLHKYVLKRPEYNDNIE-----------QALQQGFLD-IDYVMLRNKTCGDQ 112
            |:.|..|..:..:.|...:|......::.|           ..:::.||: ||..:....:...|
Mouse    70 GYDGNRVTNFVAQRLSAELLLGQLNTEHTEADVRRVLLQAFDVVERSFLESIDDALAEKASLQSQ 134

  Fly   113 M----------------------------AGSTAVVVLVKDNKLYCANAGDSRAIAC---VNG-Q 145
            :                            .|:.|||.::.::|||.||.|.:||:.|   |:| |
Mouse   135 LPEGVPQHQLPPQYQKILERLKALEREISGGAMAVVAVLLNSKLYVANVGTNRALLCKSTVDGLQ 199

  Fly   146 LEVLSLDHKPNNEAESKRIIQGG---GWVEFNRVNGNLALSRALGDYVFKH----------ENKK 197
            :..|::||...||.|..|:.|.|   |.::...|......:|.:|||..|:          ...|
Mouse   200 VTQLNMDHTTENEDELFRLSQLGLDAGKIKQMGVICGQESTRRIGDYKVKYGYTDIDLLSAAKSK 264

  Fly   198 PEDQIVTAFPDVETRKIMDD-WEFIVLACDGIWDVMSNAEVLEFCRTRIGMGMFPEEI 254
            |    :.|.|::...:.:|. ..|:||..:|::..:..|.         |.|...:||
Mouse   265 P----IIAEPEIHGAQPLDGVTGFLVLMSEGLYKALEAAH---------GPGQANQEI 309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17746	NP_647794.1	PP2Cc	22..284	CDD:238083	65/299 (22%)
Tab1	NP_079885.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21		2/10 (20%)
		PP2C	69..334	CDD:278884	57/254 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	414..476
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0631
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	1	Normalized mean entropy	S7481
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.760