Protein Alignment CG17746 and PPM1G

DIOPT Version :10

• Sequence 1: NP_647794.1
• Gene: CG17746 / 38400
• FlyBaseID: FBgn0035425
• Length: 371
• Species: Drosophila melanogaster
• Sequence 2: NP_817092.1
• Gene: PPM1G / 5496
• HGNCID: 9278
• Length: 546
• Species: Homo sapiens
• Alignment Length: 565
• Identity: 139/565 - (24%)
• Similarity: 204/565 - (36%)
• Gaps: 249/565 - (44%)

  Fly     1 MGQTLSEPVTAKESAYCQN---AAYRV----GSSCMQGWRINMEDSHTHILSLPDDPGAAFFAVY 58
            ||..||:|.|.|    |..   .|.|:    |.|.|||||::|||:|..|..|  |...|.|:||
Human     1 MGAYLSQPNTVK----CSGDGVGAPRLPLPYGFSAMQGWRVSMEDAHNCIPEL--DSETAMFSVY 59

  Fly    59 DGHGGATVAQYAGKHLHKYVLKRPEYND-NIEQALQQGFLDIDYVMLR----------------- 105
            |||||..||.|..|:|...:..:..|.: .:::||:..||.||..:..
Human    60 DGHGGEEVALYCAKYLPDIIKDQKAYKEGKLQKALEDAFLAIDAKLTTEEVIKELAQIAGRPTED 124

  Fly   106 ----------------------------------------------------------------- 105
                                                                             
Human   125 EDEKEKVADEDDVDNEEAALLHEEATMTIEELLTRYGQNCHKGPPHSKSGGGTGEEPGSQGLNGE 189

  Fly   106 ----------------------------------------------------------------- 105
                                                                             
Human   190 AGPEDSTRETPSQENGPTAKAYTGFSSNSERGTEAGQVGEPGIPTGEAGPSCSSASDKLPRVAKS 254

  Fly   106 -------------------NKTCGDQM-------------------------------------- 113
                               ::.|.::.
Human   255 KFFEDSEDESDEAEEEEEDSEECSEEEDGYSSEEAENEEDEDDTEEAEEDDEEEEEEMMVPGMEG 319

  Fly   114 -------AGSTAVVVLVKDNKLYCANAGDSRAIACVNGQLEVLSLDHKPNNEAESKRIIQGGGWV 171
                   :|:||||.|::..:|..|||||||.:....|:...:|.||||.:|.|..||...||.|
Human   320 KEEPGSDSGTTAVVALIRGKQLIVANAGDSRCVVSEAGKALDMSYDHKPEDEVELARIKNAGGKV 384

  Fly   172 EFN-RVNGNLALSRALGDYVFK-HENKKPEDQIVTAFPDVETRKIMDDWEFIVLACDGIWDVMSN 234
            ..: ||||.|.||||:||:.:| ::|..||:|:::|.||::...:.||.||:|:||||||:|||:
Human   385 TMDGRVNGGLNLSRAIGDHFYKRNKNLPPEEQMISALPDIKVLTLTDDHEFMVIACDGIWNVMSS 449

  Fly   235 AEVLEFCRTRI------GMGMFPEEICEELMNHCLAPDCQMGGLGGDNMTVVLVCLLHGRPYSDL 293
            .||::|.:::|      |.......|.|||::.|||||....|.|.||||.:::|.   :|
Human   450 QEVVDFIQSKISQRDENGELRLLSSIVEELLDQCLAPDTSGDGTGCDNMTCIIICF---KP---- 507

  Fly   294 IARCRNGSQATNNDQEEAGDATKDEVAKDE-AEAETDTETETQTK 337
                ||.::.    |.|:|....:||...| ||...:::.:.:.|
Human   508 ----RNTAEL----QPESGKRKLEEVLSTEGAEENGNSDKKKKAK 544

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17746	NP_647794.1	PP2Cc	22..284	CDD:238083	117/485 (24%)
PPM1G	NP_817092.1	PP2Cc	25..>110	CDD:214625	35/86 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	116..139		0/22 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	161..328		1/166 (1%)
		PP2Cc	<324..505	CDD:238083	80/180 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	512..546		9/37 (24%)