Protein Alignment CG17746 and PPM1K

DIOPT Version :10

• Sequence 1: NP_647794.1
• Gene: CG17746 / 38400
• FlyBaseID: FBgn0035425
• Length: 371
• Species: Drosophila melanogaster
• Sequence 2: NP_689755.3
• Gene: PPM1K / 152926
• HGNCID: 25415
• Length: 372
• Species: Homo sapiens
• Alignment Length: 283
• Identity: 93/283 - (32%)
• Similarity: 132/283 - (46%)
• Gaps: 57/283 - (20%)

  Fly    24 VGSSCMQGWRINMEDSHTHILSLPDDPGAAFFAVYDGHGGATVAQYAGKHLHKYVLKRPEYNDNI 88
            ||.:...|.|...|| ......|.|:  ..:|||||||||...|.:...|:.|.::.......|:
Human    95 VGCASQIGKRKENED-RFDFAQLTDE--VLYFAVYDGHGGPAAADFCHTHMEKCIMDLLPKEKNL 156

  Fly    89 EQALQQGFLDIDYVMLRN-KTCGDQ---MAGSTAVVVLVKDN-KLYCANAGDSRAIACVNGQLEV 148
            |..|...||:||.....: :...|.   .:|:||.|.|::|. :|..|:.||||||.|..|:...
Human   157 ETLLTLAFLEIDKAFSSHARLSADATLLTSGTTATVALLRDGIELVVASVGDSRAILCRKGKPMK 221

  Fly   149 LSLDHKPNNEAESKRIIQGGGWVEFN-----RVNGNLALSRALGDYVFKHENKKPEDQIVTAFPD 208
            |::||.|..:.|.:||.:.||:|.:|     .|||.||::|::||...|...       |.|.|
Human   222 LTIDHTPERKDEKERIKKCGGFVAWNSLGQPHVNGRLAMTRSIGDLDLKTSG-------VIAEP- 278

  Fly   209 VETRKI----MDDWEFIVLACDGIWDVMSNAEVLEFCRTRIGMGMFPEEICEELMNHCLAPD--- 266
             ||::|    .|| .|:||..||| :.|.|:                :||| :.:|.|..|:
Human   279 -ETKRIKLHHADD-SFLVLTTDGI-NFMVNS----------------QEIC-DFVNQCHDPNEAA 323

  Fly   267 -------CQMGGLGGDNMTVVLV 282
                   .|.|  ..||.|.|:|
Human   324 HAVTEQAIQYG--TEDNSTAVVV 344

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17746	NP_647794.1	PP2Cc	22..284	CDD:238083	93/283 (33%)
PPM1K	NP_689755.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	34..55
		Critical for association with the BCKDH complex. /evidence=ECO:0000269|PubMed:22589535	46..61
		PP2Cc	95..346	CDD:238083	93/283 (33%)