DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17746 and TAB1

DIOPT Version :9

Sequence 1:	NP_647794.1	Gene:	CG17746 / 38400	FlyBaseID:	FBgn0035425	Length:	371	Species:	Drosophila melanogaster
Sequence 2:	NP_006107.1	Gene:	TAB1 / 10454	HGNCID:	18157	Length:	504	Species:	Homo sapiens

Alignment Length:	429	Identity:	86/429 - (20%)
Similarity:	161/429 - (37%)	Gaps:	103/429 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 QTLSEPVTAKESAYCQNAAYRVGSSCMQGWRINMEDSHTHILSLPDDPGAAF--------FAVYD 59
            |:..:|....:...|..:.  |||:..:.:..:.:.:.:|   .|:|....|        :.|::
Human    10 QSEQQPSWTDDLPLCHLSG--VGSASNRSYSADGKGTESH---PPEDSWLKFRSENNCFLYGVFN 69

  Fly    60 GHGGATVAQYAGKHLHKYVL-------------------------------------KRPEYNDN 87
            |:.|..|..:..:.|...:|                                     ::......
Human    70 GYDGNRVTNFVAQRLSAELLLGQLNAEHAEADVRRVLLQAFDVVERSFLESIDDALAEKASLQSQ 134

  Fly    88 IEQALQQGFLDIDY--VMLRNKTCGDQMA-GSTAVVVLVKDNKLYCANAGDSRAIAC---VNG-Q 145
            :.:.:.|..|...|  ::.|.||...::: |:.|||.::.:||||.||.|.:||:.|   |:| |
Human   135 LPEGVPQHQLPPQYQKILERLKTLEREISGGAMAVVAVLLNNKLYVANVGTNRALLCKSTVDGLQ 199

  Fly   146 LEVLSLDHKPNNEAESKRIIQGG---GWVEFNRVNGNLALSRALGDYVFKH----------ENKK 197
            :..|::||...||.|..|:.|.|   |.::...:......:|.:|||..|:          ...|
Human   200 VTQLNVDHTTENEDELFRLSQLGLDAGKIKQVGIICGQESTRRIGDYKVKYGYTDIDLLSAAKSK 264

  Fly   198 PEDQIVTAFPDVETRKIMDD-WEFIVLACDGIWDVM--------SNAEVLEFCRTRIGMGMFPEE 253
            |    :.|.|::...:.:|. ..|:||..:|::..:        :|.|:.....|........:.
Human   265 P----IIAEPEIHGAQPLDGVTGFLVLMSEGLYKALEAAHGPGQANQEIAAMIDTEFAKQTSLDA 325

  Fly   254 ICEELMNHCLAPDCQMGGLGG---------DNMTVVLVCLLHGRPYSDLIARCRNGSQATNNDQE 309
            :.:.:::............||         ::||  |:....|.|..::       ||.|.:...
Human   326 VAQAVVDRVKRIHSDTFASGGERARFCPRHEDMT--LLVRNFGYPLGEM-------SQPTPSPAP 381

  Fly   310 EAGDATKD-EVAKDEAEAETDTE-TETQTKPCQKQSNSG 346
            .||..... .|....|::.:.|. |.:...|.|.|..:|
Human   382 AAGGRVYPVSVPYSSAQSTSKTSVTLSLVMPSQGQMVNG 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17746	NP_647794.1	PP2Cc	22..284	CDD:238083	68/344 (20%)
TAB1	NP_006107.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22		2/11 (18%)
		PP2C	69..334	CDD:395385	55/268 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	430..478
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0631
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	1	Normalized mean entropy	S7481
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.760