DRSC/TRiP Functional Genomics Resources

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Protein Alignment KPNA4 and Kap-alpha3

DIOPT Version :9

Sequence 1:NP_002259.1 Gene:KPNA4 / 3840 HGNCID:6397 Length:521 Species:Homo sapiens
Sequence 2:NP_001163572.1 Gene:Kap-alpha3 / 41158 FlyBaseID:FBgn0027338 Length:514 Species:Drosophila melanogaster


Alignment Length:516 Identity:344/516 - (66%)
Similarity:409/516 - (79%) Gaps:6/516 - (1%)


- Green bases have known domain annotations that are detailed below.


Human     7 LDNQRLKNFKNKGRDLETMRRQRNEVVVELRKNKRDEHLLKRRNVPHEDICEDSDIDGDYRVQNT 71
            ::..||:||||||:|.:.|||:||||.||||||||:|.:|||||||:.|...|.:......:...
  Fly     4 MEQNRLQNFKNKGKDQDEMRRRRNEVTVELRKNKREETILKRRNVPNLDSNTDEEEQLSSSIDLK 68

Human    72 SLEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVHCLERDDNPSLQFEAA 136
            .|.....:|:...|  ||:||||||||||||:||||:|||:|.||||||.||::.::..||||||
  Fly    69 KLAKAAADATKPEQ--QLAAVQAARKLLSSDKNPPINDLIQSDILPILVECLKQHNHTMLQFEAA 131

Human   137 WALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVV 201
            |||||||||||.||..||.:.||||||:||:||..||||||||||||||||||..||:||..|||
  Fly   132 WALTNIASGTSAQTNEVVAAGAVPLFLQLLNSPAPNVCEQAVWALGNIIGDGPLLRDFVIKHGVV 196

Human   202 KPLLSFISPSIPITFLRNVTWVMVNLCRHKDPPPPMETIQEILPALCVLIHHTDVNILVDTVWAL 266
            :||||||.|.||||||||||||:|||||:|||.||..||.||||||.|||||||.|||||||||:
  Fly   197 QPLLSFIKPDIPITFLRNVTWVIVNLCRNKDPAPPTATIHEILPALNVLIHHTDTNILVDTVWAI 261

Human   267 SYLTDAGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALSHF 331
            |||||.||:||||||:||:||.|:|||.:.||||||||||||||||||:|||||||||.||||:|
  Fly   262 SYLTDGGNDQIQMVIESGVVPKLIPLLGNSEVKVQTAALRAVGNIVTGSDEQTQVVLNYDALSYF 326

Human   332 PALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLT 396
            |.||:||||||.|||||||||||||||.||||||:..|:|.||..|.||:|.|||||||||||||
  Fly   327 PGLLSHPKEKIRKEAVWFLSNITAGNQSQVQAVINVGLLPKIIENLSKGEFQTQKEAAWAISNLT 391

Human   397 ISGRKDQVAYLIQQNVIPPFCNLLTVKDAQVVQVVLDGLSNILKMAEDEAETIGNLIEECGGLEK 461
            |||.::||..||::.||||||:||:.:|.||:.||||||:|:||:|:...|.:.|.||||.||.|
  Fly   392 ISGNREQVFTLIKEGVIPPFCDLLSCQDTQVINVVLDGLNNMLKVADSHVEAVANCIEECEGLAK 456

Human   462 IEQLQNHENEDIYKLAYEIIDQFFSSDDIDEDPSLVPEAIQGGTFGFNSSAN-VPTEGFQF 521
            ||:||:|||.:|||||||||||:|:  |..|..::.|.: .|..:.|:..|: :....|.|
  Fly   457 IERLQSHENVEIYKLAYEIIDQYFT--DEGEQTNMAPTS-DGAQYNFDPHADRLTMNSFNF 514

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KPNA4NP_002259.1 SRP1 11..513 CDD:227396 341/501 (68%)
Nuclear localization signal. /evidence=ECO:0000250 43..52 6/8 (75%)
ARM 1, truncated 66..106 18/39 (46%)
armadillo repeat 73..98 CDD:293788 11/24 (46%)
ARM 2 107..149 30/41 (73%)
armadillo repeat 109..142 CDD:293788 22/32 (69%)
NLS binding site (major). /evidence=ECO:0000250 137..229 72/91 (79%)
armadillo repeat 150..186 CDD:293788 26/35 (74%)
armadillo repeat 192..227 CDD:293788 27/34 (79%)
ARM 4 195..233 30/37 (81%)
ARM 5 234..278 34/43 (79%)
armadillo repeat 244..269 CDD:293788 21/24 (88%)
ARM 6 279..318 30/38 (79%)
armadillo repeat 279..311 CDD:293788 24/31 (77%)
NLS binding site (minor). /evidence=ECO:0000250 306..394 70/87 (80%)
armadillo repeat 319..355 CDD:293788 30/35 (86%)
ARM 8 361..400 28/38 (74%)
armadillo repeat 361..395 CDD:293788 23/33 (70%)
ARM 9 401..443 24/41 (59%)
armadillo repeat 404..438 CDD:293788 20/33 (61%)
ARM 10, atypical 447..485 27/37 (73%)
Kap-alpha3NP_001163572.1 IBB 7..88 CDD:280005 40/82 (49%)
SRP1 8..500 CDD:227396 340/496 (69%)
ARM 104..224 CDD:237987 90/119 (76%)
armadillo repeat 104..137 CDD:293788 22/32 (69%)
armadillo repeat 145..181 CDD:293788 26/35 (74%)
armadillo repeat 187..222 CDD:293788 27/34 (79%)
ARM 236..350 CDD:237987 94/113 (83%)
armadillo repeat 239..264 CDD:293788 21/24 (88%)
armadillo repeat 272..308 CDD:293788 28/35 (80%)
armadillo repeat 314..348 CDD:293788 28/33 (85%)
ARM 315..433 CDD:237987 85/117 (73%)
armadillo repeat 356..390 CDD:293788 23/33 (70%)
armadillo repeat 399..433 CDD:293788 20/33 (61%)
Arm_3 442..485 CDD:292804 29/44 (66%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165143886
Domainoid 1 1.000 76 1.000 Domainoid score I8982
eggNOG 1 0.900 - - E1_COG5064
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H20521
Inparanoid 1 1.050 676 1.000 Inparanoid score I726
Isobase 1 0.950 - 0 Normalized mean entropy S483
OMA 1 1.010 - - QHG54553
OrthoDB 1 1.010 - - D1111872at2759
OrthoFinder 1 1.000 - - FOG0000157
OrthoInspector 1 1.000 - - otm40373
orthoMCL 1 0.900 - - OOG6_104544
Panther 1 1.100 - - LDO PTHR23316
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2158
SonicParanoid 1 1.000 - - X2405
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1716.750

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