DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Larp4B and Larp1

DIOPT Version :9

Sequence 1:	NP_647793.1	Gene:	Larp4B / 38399	FlyBaseID:	FBgn0035424	Length:	1531	Species:	Drosophila melanogaster
Sequence 2:	NP_082727.1	Gene:	Larp1 / 73158	MGIID:	1890165	Length:	1072	Species:	Mus musculus

Alignment Length:	1031	Identity:	181/1031 - (17%)
Similarity:	313/1031 - (30%)	Gaps:	355/1031 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 PLITAAAAAAAAAGAPAVAPPVAVAPVATASAAQAAVVPAQQQQQAHPHQAQILAHTHVAHQQQQ 121
            |..|.|.........||...||:|||...|...:..|.||
Mouse   251 PRHTPAVRGEMKGSEPATYMPVSVAPPTPAWQPETKVEPA------------------------- 290

  Fly   122 QQQQQTIQQHLHQQQQQQSPHPAQHLTYGHQPALSQATAGGSGTISGGAVGPSGV---------- 176
                      .|.|.:..|..     :.|...|.:.....|.|...|...|..|.
Mouse   291 ----------WHDQDETSSVK-----SDGAGGARASFRGRGRGRGRGRGRGRGGTRTHFDYQFGY 340

  Fly   177 ----VVEGQDTNEYAIMNGALGQTQDGTVVCYTTDALNNTNLVALDPQPHQIVVPVQVPVQVPVP 237
                ..||..|::|  ||.          :.|..|.:::..:.::|.
Mouse   341 RKFDGTEGPRTHKY--MNN----------ITYYFDNVSSNEIYSMDQ------------------ 375

  Fly   238 VQLPANGSADPQQGSHNAAGGEEPNIPLDKLKQMLATQLEYYFSRENLANDTYLLSQMDSDQYVP 302
                                        :.||..:..|:|||||.:||..|.:|..:||:|.::|
Mouse   376 ----------------------------ELLKDYIKRQIEYYFSVDNLERDFFLRRKMDADGFLP 412

  Fly   303 IYTVARFNLVRKLTNDINLITEVLRESPNVQVDDKGLRVRPNRKRCIIILREISNNTPLDDVKAL 367
            |..:|.|:.|:.||.||:||...|::|..|::.::.:|.|...::..:....|.:.:..|..:.|
Mouse   413 ITLIASFHRVQALTTDISLIFAALKDSKVVEMVEEKVRRREEPEKWPLPGPPIVDYSQTDFSQLL 477

  Fly   368 FSNESCPRPISCEFAANNSWYITFESDEDAQKAYKYLREEVKEFQGKPIMARIKPKSFINRIQAV 432
                :||     ||.....:....||...:.:|...:..:.:|               ::.::.:
Mouse   478 ----NCP-----EFVPRQHYQKETESAPGSPRAVTPVPTKTEE---------------VSNLKTL 518

  Fly   433 PKNGYRLTSPPTANVFDPAGAGGATVSYAAAQQPRYLYTNGAAIAAPASVQYSNPVLIP--IPQN 495
            ||.       .:|::.|........|.    ::||   .:.|....|...::|:|..:|  :|..
Mouse   519 PKG-------LSASLPDLDSESWIEVK----KRPR---PSPARPKKPEEPRFSHPTALPQQLPSQ 569

  Fly   496 Q---------------FYPGLVAGPWPPGTVAATTAHGQNFYELG----GNIFTTNPLPPQPVTA 541
            |               |...:........|..|.:....: ||:.    ..|......||
Mouse   570 QLMSKDQDEQEELDFLFDEEMEQMDGRKNTFTAWSEEDSD-YEIDDRDVNKILIVTQTPP----- 628

  Fly   542 GFAQAPPPTSQAMVTPKPQGGGRYNNNHRGNPNNVGGANSGPRAESRSKPPRSTPSASHIQGG-- 604
             :.:..|             ||....||                .||:|  .|...|..|..|
Mouse   629 -YMRRHP-------------GGDRTGNH----------------TSRAK--MSAELAKVINDGLF 661

  Fly   605 ----------------------------NIM------------PIQITAPIPGG--MVSVVPTNI 627
                                        |::            |:.....:|.|  ....|||:.
Mouse   662 YYEQDLWTEKFEPEYSQIKQEVENFKKVNMISREQFDTLTPEPPVDPNQEVPPGPPRFQQVPTDA 726

  Fly   628 VQDPLQPAPLQQQPQQVIQQIQQQPSSSAQQQQAATVQ---------MNNTTRHYPIKSNWKGGM 683
            :.:.|..||   :|..:.:.:......|...:.|.|.:         .:.|.|.||:.   |.|
Mouse   727 LANKLFGAP---EPSTIARSLPTTVPESPNYRNARTPRTPRTPQLKDSSQTPRFYPVV---KEG- 784

  Fly   684 QKNLDKSYSGGVATHHHYTTQVQALPAHSHHLQAQQQLQGQTQQQHYQLASSSAASAPQVTYVTT 748
             :.||........|.|   :....|.:|...:...::.:.:|.    .::||.:...|.|.....
Mouse   785 -RTLDAKMPRKRKTRH---SSNPPLESHVGWVMDSREHRPRTA----SISSSPSEGTPAVGSYGC 841

  Fly   749 APAPQQPGQHQHHLVVQQ---TQPQQQQQQQQVVLQQQQVQVQELQEAGDGVEHSSHAMQQVNRS 810
            .|......||..|.::::   ||....:.:::.:.:::::.:.:.||........|..::  :..
Mouse   842 TPQSLPKFQHPSHELLKENGFTQHVYHKYRRRCLNERKRLGIGQSQEMNTLFRFWSFFLR--DHF 904

  Fly   811 SNMSASSSSSLATSMSKEPLQW----------QNRPRRRRRD------EEGGINYSPGGRVGL-- 857
            :.........||...:||..::          ....::.|.|      ||...:|..|...||
Mouse   905 NKKMYEEFKQLALEDAKEGYRYGLECLFRYYSYGLEKKFRLDIFKDFQEETVKDYEAGQLYGLEK 969

  Fly   858 ------YGSSPS---NPHPQQHLMSSSTGSNVQSAGGTDGGGASHRGGERQSHYNTIHDV---PP 910
                  |..:.:   :|..|::|                            ..:..:.|.   ||
Mouse   970 FWAFLKYSKAKNLDIDPKLQEYL----------------------------GKFRRLEDFRVDPP 1006

  Fly   911 PQHRGNYKGNNYNPHYHAQHSSMASGSHHHHHHNALSSQQQ-----QHHLTTGTGQ 961
            ....||          |.:|..:|.||..........|..:     ....||.|||
Mouse  1007 MGEEGN----------HKRHPVVAGGSGEGRKRCPSQSSSRPATGISQPPTTPTGQ 1052

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Larp4B	NP_647793.1	LARP_4_5_like	269..343	CDD:153400	29/73 (40%)
Larp4B	NP_647793.1	RRM_LARP4_5_like	348..423	CDD:240876	11/74 (15%)
Larp1	NP_082727.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..268		4/16 (25%)
		Required for interaction with PABPC1. /evidence=ECO:0000250\|UniProtKB:Q6PKG0	70..550		83/434 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	289..331		12/81 (15%)
		LARP_1_2	379..451	CDD:153403	28/71 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	488..578		18/118 (15%)
		Required for interaction with RPTOR and for repression of mRNAs with a 5'TOP motif. /evidence=ECO:0000250\|UniProtKB:Q6PKG0	551..1072		98/595 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	737..773		4/35 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	790..837		8/53 (15%)
		Interaction with mRNA. /evidence=ECO:0000250\|UniProtKB:Q6PKG0	850..1000		24/179 (13%)
		DM15	862..902	CDD:128927	5/41 (12%)
		DM15	903..941	CDD:128927	4/37 (11%)
		Interaction with 7-methylguanosine mRNA cap structure. /evidence=ECO:0000250\|UniProtKB:Q6PKG0	933..976		8/42 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1003..1072		15/60 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841860
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840