DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Larp4B and larp4ab

DIOPT Version :9

Sequence 1:	NP_647793.1	Gene:	Larp4B / 38399	FlyBaseID:	FBgn0035424	Length:	1531	Species:	Drosophila melanogaster
Sequence 2:	XP_017212146.2	Gene:	larp4ab / 568283	ZFINID:	ZDB-GENE-100729-2	Length:	764	Species:	Danio rerio

Alignment Length:	895	Identity:	243/895 - (27%)
Similarity:	349/895 - (38%)	Gaps:	221/895 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 QQQQQAHPHQAQILAHTHVAHQQQQQQQQQTIQQHLHQQQQQQSPHPAQHLTYGHQPALSQATAG 161
            |.||:|......::          :.|:::|.::|                             |
Zfish     8 QAQQKAEVEPGSVV----------RDQEEKTGEKH-----------------------------G 33

  Fly   162 GSGTISGGAVGPSGVVVE-------------------------GQDTNEYAIMNGALGQTQDGTV 201
            |..|..|..:.|:..|.:                         ..:..|......::|.....:|
Zfish    34 GMVTTKGAGLNPNAKVWQEVSAPTSQAPEAATETCHWPQADHVSTEEMEEGFKEYSVGYGDSESV 98

  Fly   202 VCYTTDALNNTNLVALDPQPHQIVVPVQVPVQVPVPVQLPANGSADPQQGSHNAAGGEEPNIPLD 266
            ....|..:|....|       ::..|:..||:                    .....|.|.:..:
Zfish    99 PAMETGLINGIESV-------ELAYPLYEPVE--------------------GETLEEPPALSEE 136

  Fly   267 KLKQMLATQLEYYFSRENLANDTYLLSQMDSDQYVPIYTVARFNLVRKLTNDINLITEVLRESPN 331
            .||:.|..|||:.||||||:.|.||:|||||||:|||:|:|....|:.||.|::||.||||.||.
Zfish   137 SLKESLKKQLEFCFSRENLSKDLYLISQMDSDQFVPIWTIASMEDVKLLTTDMDLILEVLRASPM 201

  Fly   332 VQVDDKGLRVRPNRKRCIIILREISNNTPLDDVKALFSNESCPRPISCEFAANNSWYITFESDED 396
            ||||:||.:||||.|||||||||:...||:::|:|||.:|.||:.||.|||.||:|||||:||.|
Zfish   202 VQVDEKGEKVRPNHKRCIIILREVPETTPVEEVEALFKSEKCPQVISVEFAHNNNWYITFQSDTD 266

  Fly   397 AQKAYKYLREEVKEFQGKPIMARIKPKSFINRIQAVPKNGYRLTSPPTANVFDPAGAGGATVSYA 461
            ||:||:|||||||.|||||||||||.   ||...|  |||:...|    .|:.......:.|...
Zfish   267 AQQAYRYLREEVKTFQGKPIMARIKA---INTFFA--KNGFGADS----GVYSSPSQYSSPVYLQ 322

  Fly   462 AAQQP--RY-LYTNGAAIAAPASVQYSNPVLIPIPQNQFYPGL-VAGPWPPGT--VAATTAHGQN 520
            ...||  :| ||:.......|:...|....|.|.|.:.|..|. .||.:..||  ::.|..:.:|
Zfish   323 QVYQPPQQYPLYSLLPQTWTPSPTPYFETPLAPFPNSTFVNGFGTAGNYKTGTSPISLTRNYPRN 387

  Fly   521 FYELGG-----NIFTTNPLPPQPV-----TAGFAQAPPP-------TSQAMVTP--KPQGGGRYN 566
            ...|..     |.|..:..|...|     |:..|.:|.|       ::.:.:||  :|....|.|
Zfish   388 RLPLYSRKNVINAFRNHVKPRADVGQLTETSSGAGSPQPPCTPSSDSNASTLTPLSEPPTSPREN 452

  Fly   567 -------------NNHRGNPNNVGGANSGPRAESRSKPPRSTPSASHIQGGNIMPIQITAPIPGG 618
                         .::||.........:.|.||...|    .||..........|     |:|||
Zfish   453 QHSDLSISSRVRRGSYRGMRRRREDERTRPNAELEVK----APSPKFDLATTNFP-----PLPGG 508

  Fly   619 MVSVVPTNIVQDPLQPAPLQQQPQQVIQQIQQQPSSSAQQ--QQAATVQMNNTTRHYPIKSNWKG 681
            :...:|:..||   ..:.|:.:...|::.|.:.|.:|.|:  |...|.|....|.
Zfish   509 VSGHLPSVTVQ---TESVLENRMADVVKGISKVPEASKQEVSQDTGTCQGEAQTT---------- 560

  Fly   682 GMQKNLDKSYSGGVATHHHYTTQVQALPAHSHHLQAQQQLQGQTQQQHYQLASSSAASAPQVTYV 746
                      ...|......||:|....|...|...:..|:.|.     .:....||:|..|.:|
Zfish   561 ----------GPSVPALKPPTTKVDPPVASVIHQVKKPVLEVQN-----AVTLPDAAAAVTVNHV 610

  Fly   747 TTAPAPQQPGQHQHHLVVQQTQPQQQQQQQQVVLQQQQVQVQELQEAGDGVEHSSHAMQQVNRSS 811
            ....|| :|...|.......|.|   .....:|.:.:::...|:             .|:..:..
Zfish   611 QLISAP-KPTSSQSTPSTASTPP---LPTSTIVQEPRKLSYAEV-------------CQRPPKDP 658

  Fly   812 NMSASSSSSLATSMSKEPLQWQNRPRRRRRDEEGGINYSPGGRVGLYGSSPSNPHPQQHLMSSST 876
            .....:..|...|.|..|    |:|.|..|          ..:|....||..:|..:.....|.|
Zfish   659 PPVPVAPPSPTPSPSPTP----NQPLRELR----------ANKVDGPASSRCSPWDKLEKGESRT 709

  Fly   877 G---SNVQSAGGTDGGGASHRGGERQSHYNTIHDVPPPQHRGNYKGNNYN 923
            .   :..|...|:.|.|...|..:|:          |||.|.....:.||
Zfish   710 SREQTGYQRGNGSRGSGFKLREQQRR----------PPQGRRCSPQSGYN 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Larp4B	NP_647793.1	LARP_4_5_like	269..343	CDD:153400	45/73 (62%)
Larp4B	NP_647793.1	RRM_LARP4_5_like	348..423	CDD:240876	53/74 (72%)
larp4ab	XP_017212146.2	LARP_4	139..213	CDD:153404	45/73 (62%)
		RRM_LARP4	218..294	CDD:241151	53/78 (68%)
		Atrophin-1	<406..637	CDD:331285	56/271 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586338
Domainoid	1	1.000	191	1.000	Domainoid score	I3180
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	263	1.000	Inparanoid score	I3073
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002064
OrthoInspector	1	1.000	-	-		otm24760
orthoMCL	1	0.900	-	-		OOG6_107958
Panther	1	1.100	-	-	O	PTHR22792
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.980