DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Larp4B and larp1b

DIOPT Version :9

Sequence 1:	NP_647793.1	Gene:	Larp4B / 38399	FlyBaseID:	FBgn0035424	Length:	1531	Species:	Drosophila melanogaster
Sequence 2:	XP_005158614.1	Gene:	larp1b / 568156	ZFINID:	ZDB-GENE-030131-4154	Length:	1111	Species:	Danio rerio

Alignment Length:	1009	Identity:	182/1009 - (18%)
Similarity:	303/1009 - (30%)	Gaps:	372/1009 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   260 EPNIPLDKLKQMLATQLEYYFSRENLANDTYLLSQMDSDQYVPIYTVARFNLVRKLTNDINLITE 324
            |.|:    ||:.:..|:|||||..||..|.:|..:|||..::||..:|.|:.|:.||.|||||.|
Zfish   320 EENL----LKEYIKRQIEYYFSLPNLERDFFLRRRMDSKGFLPISLIASFHRVQALTTDINLIKE 380

  Fly   325 VLRESPNVQVDDKGLRVRPNRKRCIIILREISNNTPLDDVKALFSNESCPRPISCEFAANNSWYI 389
            .|:.|..|::.|:.:|.:...::..|  ..::.::|..|...|.   :||     ||....
Zfish   381 ALKNSEVVELVDEQIRRKEEPEQWPI--PALALDSPRTDFSQLI---NCP-----EFVPGQ---- 431

  Fly   390 TFESDEDAQKAYKYLREEVKEFQGKPIMARIKPKSFINRIQAVPKNGYRLTSPPTANVFDPAGAG 454
            ||.|              :......|:...:...|.:|...:...:    |:.|.:....|:.:.
Zfish   432 TFTS--------------LSTVSSSPVNQHMDEPSLVNGQTSDETD----TAKPQSKESSPSDSK 478

  Fly   455 GATVSYAAAQQPRYLYTNGAAIAAPASVQYSNPVLIPIPQNQFYPGLVAGPWPPGTVAATTAHGQ 519
            .::....:..:.|             |...|:|              .|.||    :.....|..
Zfish   479 SSSGEDGSNLKER-------------SSSLSDP--------------DAQPW----IQVEKRHRN 512

  Fly   520 NFYELGGNIFTTNPLPPQPVTAGFAQAPPP------------------TSQAMVTPKPQGGGRYN 566
            .   .|.|..:..||||.|.::  ...|||                  |.....|||||
Zfish   513 T---SGKNKTSVTPLPPSPPSS--PPPPPPPSPPPPIPRLEFFPSAERTELVQSTPKPQ------ 566

  Fly   567 NNHRGNPNNVGGANSGPRAESRS------------KPPRS------------------------- 594
                            |.|:...            ..||.
Zfish   567 ----------------PEADQEELDFLFDEEMEQLAAPRKNTFTDWSDDDSDDELDDRDVNKILI 615

  Fly   595 -TPSASHIQ--------GGNIMPIQITAPIPGG---------------------------MVSVV 623
             |.:..|::        |.::...:|||.:...                           |.:..
Zfish   616 VTQTPPHLRKHPGGDRTGNHVSRAKITADLAKAINDGLFYYEQDLWTKEEGPPECANAKEMENFK 680

  Fly   624 PTNIVQ-------------DPLQ----PAPLQQQPQQVIQQIQQQ-PSSSAQQQQAATVQM---- 666
            ..|::.             ||.|    |.|.|.....:...:... |.||:..:...|.:.
Zfish   681 KLNMISQDEFETLTPKLPIDPNQEVPPPPPCQTDDSSMAHSLPADVPESSSVPRTPRTPRTPGRQ 745

  Fly   667 --NNTTRHYPIKSNWKGGMQKNLDKSYSGGVATHHHYTTQVQALPAHSHHLQAQQQLQGQTQQQH 729
              ..|.|.||:.....|    |||........|.|   :....|..|...:...::.:.:|.
Zfish   746 DPTKTPRFYPVIKEDSG----NLDGKTPRKRKTRH---SSNPPLECHVGWVMDSREHRPRTS--- 800

  Fly   730 YQLASSSAA---SAPQV--TYVTTAPAPQQPGQ--HQHHLVVQQ---TQPQQQQQQQQVVLQQQQ 784
             .::||:|:   .||.:  :|..|   ||...:  |..|.::::   ||....:.:::.:.::::
Zfish   801 -SISSSNASPSEGAPALSGSYGCT---PQSLPKFWHPSHELLRENGFTQQVYHKYRRRCLNERKR 861

  Fly   785 VQVQELQEAGDGVEHSSHAMQ-QVNRSSNMSASSSSSLATSMSKEPLQW----------QNRPRR 838
            :.|.:.||........|..:: ..||.   ........|...|||..::          ....||
Zfish   862 LGVGQSQEMNTLFRFWSFFLRDNFNRK---MYEEFRQFAVEDSKENYRYGLECLFRFYSYGLERR 923

  Fly   839 RRRD------EEGGINYSPGGRVGL--------YG---SSPSNPHPQQHLMSSSTGSNVQSAGGT 886
            .|.|      ||...:|..|...||        |.   :...:|..:::|
Zfish   924 FRPDIFKDFQEETVQDYEKGQLYGLEKFWAFLKYSKVKNQDIDPKLKEYL--------------- 973

  Fly   887 DGGGASHRGGERQSHYNTIHD--VPPPQHRGNYKGNNYNPHYHAQHSSMASGSHHHHHHNALSSQ 949
                         |.:.:|.|  |.||...   :|.....|      |.|........||:.||.
Zfish   974 -------------SKFKSIDDFRVEPPMAE---EGMRRKAH------SSAGDEVKRRRHNSTSSS 1016

  Fly   950 QQQHHLTTGTGQQGSGHHYHHHHHHNSIGSNVGNSGGLGVSSGGSGGGGSGGGSGSNSLSGGSNE 1014
            :|.....|.:..|.:....|..                               :|:::.:..:|
Zfish  1017 KQTQITKTSSDNQTTAKTAHDQ-------------------------------AGASAATKSTN- 1049

  Fly  1015 RGIHHSSLGYQGHQHQHQQQQQQQQQQQQQQPAAPVQPPQFDLEDAAFPPLPATSATAPHTPQAT 1079
                                          ||||..       ..|...|.|.|:.::....|..
Zfish  1050 ------------------------------QPAAKA-------ASANQKPAPLTAKSSSANEQPA 1077

  Fly  1080 GGASLHNSTTSSSSSTGLGQKQTLHQQQQQAPQQ 1113
            ......|...::||.....:..|...::.|.|::
Zfish  1078 KAPPKENVKKNTSSDARKAEAATSKNKEAQQPKK 1111

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Larp4B	NP_647793.1	LARP_4_5_like	269..343	CDD:153400	32/73 (44%)
Larp4B	NP_647793.1	RRM_LARP4_5_like	348..423	CDD:240876	12/74 (16%)
larp1b	XP_005158614.1	LARP_1_2	325..397	CDD:153403	31/71 (44%)
		DM15	843..883	CDD:128927	6/39 (15%)
		DM15	884..922	CDD:128927	6/40 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586339
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840