DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Larp4B and LARP6

DIOPT Version :9

Sequence 1:	NP_647793.1	Gene:	Larp4B / 38399	FlyBaseID:	FBgn0035424	Length:	1531	Species:	Drosophila melanogaster
Sequence 2:	NP_060827.2	Gene:	LARP6 / 55323	HGNCID:	24012	Length:	491	Species:	Homo sapiens

Alignment Length:	342	Identity:	75/342 - (21%)
Similarity:	127/342 - (37%)	Gaps:	101/342 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   241 PANGSADPQQGSH-----NAAGGE--------EPNIPLDKLKQMLATQLEYYFSRENLANDTYLL 292
            |..|||..::.|.     .|:|||        |...|.::|.:.|..|:|:|||.|||..|.:||
Human    52 PGWGSASEEEPSRGHSGTTASGGENEREDLEQEWKPPDEELIKKLVDQIEFYFSDENLEKDAFLL 116

  Fly   293 SQMDSDQ--YVPIYTVARFNLVRKLTNDINLITEVLRESPNVQVDDKGLRVR--------PNR-- 345
            ..:..::  ||.:..:..|..|:.||.|.......|:.|..:::::...:||        ||.
Human   117 KHVRRNKLGYVSVKLLTSFKKVKHLTRDWRTTAHALKYSVVLELNEDHRKVRRTTPVPLFPNENL 181

  Fly   346 --KRCII----------------------------ILREISNNTPLDDVKALFSNESCP---RPI 377
              |..::                            :|:.......:..|:.|......|   |.|
Human   182 PSKMLLVYDLYLSPKLWALATPQKNGRVQEKVMEHLLKLFGTFGVISSVRILKPGRELPPDIRRI 246

  Fly   378 SCEFA---ANNSWYITFESDEDAQKAYKYLREEVKEFQGKPIMARI---------KP-------- 422
            |..::   ......:.||..|.|.||::::   :.|.|||..|..:         ||
Human   247 SSRYSQVGTQECAIVEFEEVEAAIKAHEFM---ITESQGKENMKAVLIGMKPPKKKPAKDKNHDE 308

  Fly   423 ---------KSFINRIQAV----PKNGYRLTSPPTANVFDP-AGAGGATVS--YAAAQQPRYLYT 471
                     ||...|::.:    .::....:|.|.:|...| ||...|..:  ..:..|..:|..
Human   309 EPTASIHLNKSLNKRVEELQYMGDESSANSSSDPESNPTSPMAGRRHAATNKLSPSGHQNLFLSP 373

  Fly   472 NGAAIAAPASVQYSNPV 488
            |    |:|.:..:|:|:
Human   374 N----ASPCTSPWSSPL 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Larp4B	NP_647793.1	LARP_4_5_like	269..343	CDD:153400	23/83 (28%)
Larp4B	NP_647793.1	RRM_LARP4_5_like	348..423	CDD:240876	20/134 (15%)
LARP6	NP_060827.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..87		10/34 (29%)
		LARP_6	93..169	CDD:153402	22/75 (29%)
		RRM_LARP6	184..292	CDD:409731	19/110 (17%)
		Nuclear export signal	186..193		0/6 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	293..403		19/98 (19%)
		Nuclear localization signal	296..302		2/5 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	423..491
		SUZ-C	452..484	CDD:403952
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151762
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840