Protein Alignment Larp4B and LARP1B

DIOPT Version :10

• Sequence 1: NP_647793.1
• Gene: Larp4B / 38399
• FlyBaseID: FBgn0035424
• Length: 1531
• Species: Drosophila melanogaster
• Sequence 2: XP_016863827.1
• Gene: LARP1B / 55132
• HGNCID: 24704
• Length: 1143
• Species: Homo sapiens
• Alignment Length: 677
• Identity: 131/677 - (19%)
• Similarity: 223/677 - (32%)
• Gaps: 217/677 - (32%)

  Fly   264 PLDK--LKQMLATQLEYYFSRENLANDTYLLSQMDSDQYVPIYTVARFNLVRKLTNDINLITEVL 326
            |:::  ||:.:..|:|||||.|||..|.:|..:||...::||..:|.|..|:.||.::|||.|.|
Human   410 PVEEALLKEYIKRQIEYYFSVENLERDFFLRGKMDEQGFLPISLIAGFQRVQALTTNLNLILEAL 474

  Fly   327 RESPNVQVDDKGLR--VRPNRKRCIIILREISNNTPLDDVKALFSNESCPRPISCEFAANNSWYI 389
            ::|..|::.|:.:|  :.|.:..   |......:.|..|...|.   .||     ||....::..
Human   475 KDSTEVEIVDEKMRKKIEPEKWP---IPGPPPRSVPPTDFSQLI---DCP-----EFVPGQAFCS 528

  Fly   390 TFESDEDAQKAYKYLREEVKEFQGKPIMARIKPKSFINRIQAVPKNGYRLTSPPTANVFDPAGAG 454
            ..||..::.:.            |.|:..  |..|..:.:||:.:.  ..||.|..: .:|
Human   529 HTESAPNSPRI------------GSPLSP--KKNSETSILQAMSRG--LSTSLPDLD-SEP---- 572

  Fly   455 GATVSYAAAQQPRYLYTNGAAIAAPASVQYSNPVLIPIPQ---NQFYPGLVAGPWPPGTVAATTA 516
              .:......||           ||..::.|    :.:|:   ||     :.....|........
Human   573 --WIEVKKRHQP-----------APVKLRES----VSVPEGSLNQ-----LCSSEEPEQEELDFL 615

  Fly   517 HGQNFYELG-GNIFT-------TNPLPPQPVTAGF--AQAPPPTSQAMVTPKPQGGGRYNNNHRG 571
            ..:...::| .|.||       ...:..|.:....  .|.||                |...|
Human   616 FDEEIEQIGRKNTFTDWSDNDSDYEIDDQDLNKILIVTQTPP----------------YVKKH-- 662

  Fly   572 NPNNVGGANSGPRAESRSKPPRSTPSASHIQGGNIMPIQITAPIPGGMVSVVPTNIVQDPL---Q 633
                .||..:|... ||:|                    ||:.:         ..::.|.|   :
Human   663 ----PGGDRTGTHM-SRAK--------------------ITSEL---------AKVINDGLYYYE 693

  Fly   634 PAPLQQQPQQVIQQIQQQPSSSAQQQQAATVQMNNTTRHYPIKSN---------------WKGGM 683
            .....::.:.....|:|:..:..:....:..|..|.|...|.:.|               |:..|
Human   694 QDLWMEEDENKHTAIKQEVENFKKLNLISKEQFENLTPELPFEPNQEVPVAPSQSRQEECWRHKM 758

  Fly   684 QKNLDKSYSGGVATHHHYTTQVQALPAHSHH----LQAQQQLQGQTQQQHY---QLAS-----SS 736
            .....:|.|                  ||..    |...:::..:.:.|.|   :||.     |.
Human   759 SWRCSRSAS------------------HSQERIIILVTVKKMDWERKWQMYLTDELAQKLFDVSE 805

  Fly   737 AASAPQVTYVTTAPAPQQPGQHQHHLVVQQTQPQQQQQQQ-----QVVLQQQQVQVQELQEAGDG 796
            ..||..|..:.|| .|:.|..|..........|:.|...:     .||.:.:.:.|:..::.  .
Human   806 ITSAAMVHSLPTA-VPESPRIHPTRTPKTPRTPRLQDPNKTPRFYPVVKEPKAIDVKSPRKR--K 867

  Fly   797 VEHSSH---------AMQQVNRSSNMSASSSSSLATSMSKEPLQWQNRPRRRRRDEEGGINYSPG 852
            ..||::         .|...:|....|:.|:|: |:.....||
Human   868 TRHSTNPPLECHVGWVMDSRDRGPGTSSVSTSN-ASPSEGAPL---------------------- 909

  Fly   853 GRVGLYGSSPSN----PHPQQHLMSSS 875
              .|.||.:|.:    .||...|:..:
Human   910 --AGSYGCTPHSFPKFQHPSHELLKEN 934

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Larp4B	NP_647793.1	LARP_4_5_like	269..343	CDD:153400	30/75 (40%)
		RRM_LARP4_5_like	348..423	CDD:409864	13/74 (18%)
LARP1B	XP_016863827.1	LHP1	<311..>481	CDD:227520	29/70 (41%)
		LARP_2	417..489	CDD:153407	29/71 (41%)
		DM15	936..976	CDD:128927
		DM15	977..1015	CDD:128927