DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Larp4B and larp

DIOPT Version :9

Sequence 1:	NP_647793.1	Gene:	Larp4B / 38399	FlyBaseID:	FBgn0035424	Length:	1531	Species:	Drosophila melanogaster
Sequence 2:	NP_001247347.1	Gene:	larp / 53567	FlyBaseID:	FBgn0261618	Length:	1673	Species:	Drosophila melanogaster

Alignment Length:	1374	Identity:	256/1374 - (18%)
Similarity:	414/1374 - (30%)	Gaps:	499/1374 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 TNVPVETAMLATNLFGATTQIAASPAAAAAAHIPLITAAAAAAAAAGAPAVAPPV-----AVAPV 83
            ||....||.:|:....|..|..|.|||         .:||.....|..||:...:     ...|:
  Fly   487 TNSQATTAPVASTSHDAKAQRDAEPAA---------NSAAGTTGTAAGPALTKKIPKHKWRPLPI 542

  Fly    84 ATASAAQAAVVPAQQQQQAHPHQAQILAHTHVAHQQQQQQQQQTIQQHLHQQQQQQSPHPAQHLT 148
            ..|.:::...:..:..::.....|.......|.|.:|.......:        :.:.||..:| .
  Fly   543 DLAKSSRPKPIGGRPNRRFSDDIADQRRPPRVYHDRQPGAGGAGV--------ESRHPHAGRH-P 598

  Fly   149 YGHQPALS-----------------------QATAGGSGTIS------------------GGAVG 172
            ||.:||.:                       ...|||:|...                  ||..|
  Fly   599 YGSRPATATSERVDSWRSSSSTTTAAFDEQRSGAAGGAGAAGTGVGSATRGPRRYRTPYRGGRQG 663

  Fly   173 PSGVVVEGQDTNEYAIMNGALGQTQDGTVVCYTTDALNNTNLVALDPQPHQIVVPVQVPVQVPVP 237
            ..|...:|.....|.|....|.   .|....|
  Fly   664 RGGFSRQGPGRPTYRIPRHLLA---SGEYANY--------------------------------- 692

  Fly   238 VQLPANGSADPQQGSHNAAG----GEEP--NIPLD--KLKQMLATQLEYYFSRENLANDTYLLSQ 294
              |||:.:....|.|:...|    |..|  .|.||  .:|:.:..|:|||||.:||..|.:|..:
  Fly   693 --LPADAAGADSQSSYVLMGTHYFGNVPAAYIELDANSIKEAIKKQVEYYFSVDNLTGDFFLRRK 755

  Fly   295 MDSDQYVPIYTVARFNLVRKLTNDINLITEVLRESPNVQVDDKGLRVRPNRKRCIIILREISNNT 359
            ||.:.|:|:..:|.|:.|..||.|:.:|...::||..:::.: |.:||         .:......
  Fly   756 MDPEGYIPVTLIASFHRVLALTTDVAVIVNAIKESDKLELFE-GYKVR---------TKTTPTTW 810

  Fly   360 PLDDVKALFSNESCPRPISCEFAANNSWYITFESDE----DAQKAYKYLREEVKEFQGKPIMARI 420
            |:.:|..:  ||..|:.|.           |.|.::    |.|:.   |.|:.:.....||:...
  Fly   811 PITEVPEV--NEGEPKAIG-----------TLEQEQLEQNDGQEK---LEEQTEADSPPPILTSA 859

  Fly   421 KPKSFINRIQAVP---------------KNGYRLTSPPTANVFDPAGAGGATVSYAAAQQPRYLY 470
            .....:|.|...|               |...|.::....|..:...|....|...||:...:|
  Fly   860 MATKPLNSIPPPPMPRNPQNLVPKMLQDKQQSRSSTIAALNSVNAISALTQQVEGGAAELAGHL- 923

  Fly   471 TNGAAIAA-PASVQYSNPVLIPIPQNQFYPGLVAGPWPPGTVAATTAHGQNFYELGGNIFTTNPL 534
             :|.|.:. |.|..      .|..:|....|..|     |:.||..|..:..::.......||.:
  Fly   924 -SGLAESVKPKSTS------TPDKRNAASAGNGA-----GSAAALVAEPEGIWKEVKRRSKTNAI 976

  Fly   535 ------PPQPVTAGFAQAPPPTSQAMVTPKPQGGGRYNNNHRGNPNNV-----GGANSGP----- 583
                  |||       |..||.||.:          .|||.....||.     ..:|:.|
  Fly   977 KENATTPPQ-------QQQPPLSQTL----------NNNNDNVKTNNTSSKSKSSSNNAPSNASS 1024

  Fly   584 ---------RAESRSKPPRSTPSAS--------HIQGGNIMPIQI-------TAPIPGGMVSVVP 624
                     .|.|.:|....|.:.|        :|:.||....:.       ||..|........
  Fly  1025 SATVCVTTNNASSATKATTKTTTTSTATTTTNNNIKSGNAAYSKTHSKSSSKTAAPPSAQCHAEK 1089

  Fly   625 TNI-------VQDPLQP----------------------APLQQQPQQVIQQIQQQPSSSAQQQQ 660
            ..:       :.|||.|                      |........::.|:.:.|......:.
  Fly  1090 EELDFQFDEELMDPLPPGTGRINNFTENFSDDDESDYEFADRDINKLLIVAQVGRAPKHEGYDRT 1154

  Fly   661 A-------ATVQMNN--------------TTRHYPIKSNWK--------------GGMQK----- 685
            |       .|..:.|              ||.:  :.:::|              ||..|
  Fly  1155 ADFTSRTKITQDLENIINDGLVNYEEDLWTTTN--VVADYKTVNVISQADFEKLAGGRNKSVLPP 1217

  Fly   686 -----------NLDKSYSGGVATHHHYTTQVQALPA------HSHHLQAQQQLQGQ--------- 724
                       :||::..|....:......:::..|      :||.:..:...:.:
  Fly  1218 QVVPPPPPFEEDLDETLVGDTTLNSTLNNTLKSRRARFYAAPNSHSIDPRTPRKRKLRHTANPPV 1282

  Fly   725 ---------TQQQHYQLAS--SSAASAPQV----TYVTTAPAPQQPGQHQHHLVVQQ---TQPQQ 771
                     |.:...:..|  |||.::|..    ::.::.|......||..|.::::   ||...
  Fly  1283 EAHVGWLLDTVEHRPRTTSMGSSAGTSPTASSYGSFGSSVPQSLPVFQHPSHALLKENNFTQQAY 1347

  Fly   772 QQQQQQVVLQQQQV---QVQE----------------------------LQEAGDGVEHS----- 800
            .:...:.:.:::::   |.||                            |::||:|..:.
  Fly  1348 HKYHSRCLKERRRLGYGQSQEMNTLYRFWSFFLRENFNKSMYNEFRSLALEDAGNGFRYGLECLF 1412

  Fly   801 ---SHAMQQVNRSSNMSASSSSSLATSMSKEPLQWQNRPRRRRRDEEGG-----------INYSP 851
               |:.:::..|.:........::|                   |.|.|           :.|..
  Fly  1413 RFFSYGLEKKFRPNIYQDFQDETIA-------------------DYETGQLYGLEKFWAFLKYYK 1458

  Fly   852 GG-------RVGLYGSSPSN------PHPQQHLMSSSTGS--------NVQSAGGTDGGGASHRG 895
            .|       ::..|..|..|      ..|:.:.|....||        ..:|...:||......|
  Fly  1459 NGEKLEVQPKLAEYLKSFKNIEDFRVVEPEINEMLQGVGSLNPGRQLNRHRSVSESDGTAVIAAG 1523

  Fly   896 GERQSHYNTIHDVPPPQHRGNYKGNNYNPHYHAQHSSMASGSHHHHHHNALSSQQQQHHLTTGTG 960
            |.|.:  .||      .:|.:|.|......:..|                   ||||||    ..
  Fly  1524 GRRLN--TTI------TNRSDYVGRLLQQQHQQQ-------------------QQQQHH----QY 1557

  Fly   961 QQGSGHHYHHHHHHNSIGSNVGNSGGLGVSSGGSGG----GGSGGGSGSNSLSGGSNERGIHHSS 1021
            |||.| .|:...:....||  ..|..:.:.||..|.    .....||......||||.
  Fly  1558 QQGYG-GYNQQQNRRRTGS--FGSTTVRIRSGSLGNKPQVANRNQGSQHELRRGGSNS------- 1612

  Fly  1022 LGYQGHQHQHQQQQQQQQQQQQQQPAAPVQPPQFDLEDAAFPPLPATSATAPHTPQATGGASLHN 1086
             |...|         ::||||:.:|.|..|             ..:|.||......||..||...
  Fly  1613 -GLAPH---------KRQQQQKPKPGAGSQ-------------TGSTRATTSAAATATTAASAAT 1654

  Fly  1087 STTSSSSST 1095
            ||.::.:.|
  Fly  1655 STAATPAVT 1663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Larp4B	NP_647793.1	LARP_4_5_like	269..343	CDD:153400	26/73 (36%)
Larp4B	NP_647793.1	RRM_LARP4_5_like	348..423	CDD:240876	14/78 (18%)
larp	NP_001247347.1	LARP_1_2	730..803	CDD:153403	27/82 (33%)
		DM15	1341..1382	CDD:128927	5/40 (13%)
		DM15	1383..1421	CDD:128927	5/37 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456179
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9176
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22792
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.940