DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Larp4B and Achl

DIOPT Version :9

Sequence 1:	NP_647793.1	Gene:	Larp4B / 38399	FlyBaseID:	FBgn0035424	Length:	1531	Species:	Drosophila melanogaster
Sequence 2:	NP_001286419.1	Gene:	Achl / 36605	FlyBaseID:	FBgn0033936	Length:	867	Species:	Drosophila melanogaster

Alignment Length:	1036	Identity:	189/1036 - (18%)
Similarity:	342/1036 - (33%)	Gaps:	320/1036 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 SPAAAAAAHIPLITAAAAAAAAAGAPAVAPPVAVAPVATASAAQAAVVPAQQ------QQQAHPH 105
            :|.|.|..|..|::....      .|.:||.:...||..|..:.|::...::      :|.:...
  Fly    16 APHAGAEGHTFLVSPVDP------TPILAPILTAVPVMKAPDSPASMDKTKEMEELDDEQPSCSS 74

  Fly   106 QAQILAHTHVAHQQQQQQQQQTIQQHLHQQQQQQSPHPAQHLTYGHQPALSQATAGGSGTIS--- 167
            ||.:...:.:..:..:...:::.|..|||.:...|...:.:      .:.|:.|:..:..:|
  Fly    75 QAVVPLSSSLPCKLLRMHARRSAQALLHQMESMDSQLGSSN------GSTSEDTSPSAPPMSPTD 133

  Fly   168 --------GGAVGPSG-VVVEGQDTNEYAIMNGALGQTQDGTVVCYTTDA-LNNTNL-------- 214
                    |.::|.|. ...||.:....|:.|..:.:. |.|....|..| |:..||
  Fly   134 HQLVDVGMGSSIGDSDESSEEGDELKPLAVDNHIIAEV-DLTERQTTPPAVLSEANLEKFRKHQM 197

  Fly   215 --------VALDPQPHQIVVPVQVPV-----------------QVPVP----VQLPANGSADPQQ 250
                    ..||..|...|.|...||                 :|..|    .::|.:...|.:.
  Fly   198 DNIYLHPNFTLDASPPPAVAPANSPVLEAKRTHRSFLTMKKEKEVEPPQEKEQEVPVHQEQDTEP 262

  Fly   251 GSHNAAGGEEPN-IPLDKLKQMLATQLEYYFSRENLANDTYLLSQM--DSDQYVPIYTVARFNLV 312
            ...|.....:|: ||.::|...:...:|:|||.|::..|.:||..:  :.:.:|.:..|:.|..|
  Fly   263 QGPNEIDTLDPSLIPSEELAAEITDAVEFYFSNESILKDAFLLKHVRRNKEGFVSLKLVSSFKRV 327

  Fly   313 RKLTNDINLITE-VLRESPNVQVDDKGLRVRPNRKRCIIILREISNNTPLDDVKALFSNESCPRP 376
            |:||.:..::.: |.|:|..::::|.|.:|           |.|......|:.....:..:|..|
  Fly   328 RQLTREWKVVGDAVRRKSRKIELNDVGTKV-----------RRIEPLPSFDETMPSRTIVACDLP 381

  Fly   377 ISCEFAANNSWYITFESDED------------AQKAYKYLREEVKEFQGKPIMARIKPKSFINRI 429
            :.         .:|.|...|            ..|....:..:|::|..|....:.|..:.:..:
  Fly   382 LD---------KLTIEKVSDLFSPCGEIALIRILKPGMAIPVDVRQFMNKYPELQQKECALVEYL 437

  Fly   430 QAV----------PKNGYRLTSPPTANVFDPAGAGGATVSYA---AAQQPRYLYTNGAAIAAPAS 481
            ::.          |...|.:.:|.     ...|...|.:..|   |.....|.|.|.|.......
  Fly   438 ESSSARDARHLNGPFQVYEMVAPK-----KKTGKKAAVIQIAAPVARMVENYRYYNDANYERSRG 497

  Fly   482 VQYSNPVLIP-----IPQN--QFYPGLVAGPWPPGTVAATTAHGQNFYELGGNIFTTNPLPPQPV 539
            ..:|....:|     :.:|  .|.|                    ::|:..|..:..||....
  Fly   498 GSFSGHETVPDLRFKLKRNNSDFQP--------------------SYYQQTGPSYHANPYQHY-- 540

  Fly   540 TAGFAQAPPPTSQAMVTPKPQGG-GRYNNNHRGNPNNVGGANSGPRAESRSKPPRSTPSASHIQG 603
                              :|:|. |  |.|....||...|  .|||..|.:    ||.||:....
  Fly   541 ------------------QPRGSIG--NQNQEVGPNGFFG--YGPRRYSNT----STISANTAAA 579

  Fly   604 -GNIMPIQITAPIPGG--MVSVVPTNIVQDPLQPAPLQQQPQQVIQQIQQQPSSSAQQQQAATVQ 665
             |::.||. :|...||  |||                      .|..:|::.|:.::|
  Fly   580 LGDVSPIS-SAVNSGGNPMVS----------------------GISSLQRRLSNCSEQ------- 614

  Fly   666 MNNTTRHYPIKSNWKGGMQKNLDKSYSGGVATHHHYTTQVQALPAHSHHLQAQQQLQGQTQQQHY 730
                                              :||.:|.  |:.|.......:..|..|::.
  Fly   615 ----------------------------------NYTPEVN--PSMSRRASNCSETGGVPQRRD- 642

  Fly   731 QLASSSAASAPQVTYVTTAPAPQQPGQHQHHLVVQQTQPQQQQQQQQVVLQQQQVQVQELQEAGD 795
               |:.:.|.|....|:...........:..:....:.|...|.|::
  Fly   643 ---SNCSESCPCSRRVSDFAQTTDTSYRKTSVCSNGSCPGNNQNQER------------------ 686

  Fly   796 GVEHSSHAMQQVNRSSNMSASSS----SSLATSMSKEPLQ-----------WQNRPRRRRRDEEG 845
              ..|:.:||.....||.|.||.    .|...::.:||:|           :|..|||...
  Fly   687 --RFSNGSMQFERTFSNASESSGFYRRPSNDFNIEREPIQTDQLVGGGGGGYQVWPRRYSN---- 745

  Fly   846 GINYSP-GGRVGLYGSSPSNPHPQQHL----MSSSTGSNVQSAGGTDG--GGASHRGGERQSHYN 903
              |:.. ..::..|.::       |::    :|:.:|.:.:.:.|::|  |....|.|...|:|
  Fly   746 --NFQQLSSKLAAYDNA-------QYIGGRRISTDSGYDRRCSFGSEGFEGSPRSRTGSFLSNY- 800

  Fly   904 TIHDVPPPQHRGNYKGNNYNPHYHAQHSSMASGSHHHHHHNALSSQQQQHHLTTGTGQQGS 964
                    :|.|   |:.|:....::..|...|| ......:.:.:..:..:.|..|..||
  Fly   801 --------KHGG---GDGYDGQPRSRTGSFLDGS-PRSRSGSFAQRAAESLVRTPMGPDGS 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Larp4B	NP_647793.1	LARP_4_5_like	269..343	CDD:153400	21/76 (28%)
Larp4B	NP_647793.1	RRM_LARP4_5_like	348..423	CDD:240876	13/86 (15%)
Achl	NP_001286419.1	LARP_6	282..359	CDD:153402	21/87 (24%)
Achl	NP_001286419.1	RRM_LARP6	373..472	CDD:240735	15/112 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456183
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22792
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030