DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Larp4B and larp1

DIOPT Version :9

Sequence 1:	NP_647793.1	Gene:	Larp4B / 38399	FlyBaseID:	FBgn0035424	Length:	1531	Species:	Drosophila melanogaster
Sequence 2:	XP_021324942.1	Gene:	larp1 / 327175	ZFINID:	ZDB-GENE-030131-5386	Length:	993	Species:	Danio rerio

Alignment Length:	991	Identity:	164/991 - (16%)
Similarity:	293/991 - (29%)	Gaps:	364/991 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 AH--THVAHQQQQQQQQQTIQQHLHQQQQQQSPHPAQHLTYGHQPALSQATAGGSGTISGGAVGP 173
            ||  ||.:....:....:..:|.|.....:.|...:....|       :|.|.|.|...|...|.
Zfish   202 AHRGTHSSRNGLRDWPSERFEQELKDDHDEVSSVKSDGAPY-------RAGARGRGRGRGRGRGR 259

  Fly   174 SGVVVEGQDTNEYAIMNGALGQ-----TQDGTVVCYTTDALNNTNLVALDPQPHQIVVPVQVPVQ 233
            .    .|:...:|....|:.|:     .:.|..:.|..|.:::..|.::|.
Zfish   260 G----RGRGHYDYYSYKGSEGKDGAYAQKFGNSMTYYYDNMSSAELYSVDQ-------------- 306

  Fly   234 VPVPVQLPANGSADPQQGSHNAAGGEEPNIPLDKLKQMLATQLEYYFSRENLANDTYLLSQMDSD 298
                                            |.||..:..|:|||||.:||..|.:|..:||..
Zfish   307 --------------------------------DLLKDYIKRQIEYYFSVDNLERDFFLRRKMDEG 339

  Fly   299 QYVPIYTVARFNLVRKLTNDINLITEVLRESPNVQVDDKGLRVR--------------------- 342
            .::|:..:|.|:.|:.||.|::||.:.|::|..|.:.|..:|.:
Zfish   340 GFLPVSLIASFHRVQALTTDVSLILQALKDSKVVDIIDMKMRCKEEPQKWPLPDLCLPDQAQTDF 404

  Fly   343 ---------------------------------PNRKRCIIIL--REISNNTPLDDVKALFSNES 372
                                             |:::.|.:.:  :.:|.:.|..|.:.....:.
Zfish   405 AQFIHCPEFIPRHLPASPSPAGTPRSGTPRSSTPHQELCSLKMMPKGLSASLPDLDSECWIEVKK 469

  Fly   373 CPRP---------ISCEFAANNSWYITFESDEDAQKAYKYLREEVKEFQGKPIMARIKPKSF--- 425
            .|||         :.|......   ::.|..|:.::......||:::..|       :..:|
Zfish   470 RPRPSPARPKKEDVRCVLQMGQ---VSAEEQEEPEELDFMFDEEMQQMDG-------RRNTFTDW 524

  Fly   426 -------------INRIQAVPKNGYRLTSPPTANVFDPAGAGGATVSYAAAQQPRYLYTNGAAIA 477
                         :|:|..|.:....|...|          ||....:..::.
Zfish   525 SDEDSDCEIDDRDVNKILIVTQTPPYLRKHP----------GGDRTGHHTSRS------------ 567

  Fly   478 APASVQYSNPVLIPIPQNQFYPGLVAGPWPPGTVAATTAHGQNFYELGGNIFTTNPLPPQPVTAG 542
                 :.|:.::..|....||                  :.|:.::..|          :|..|.
Zfish   568 -----KLSSELVKIINDGLFY------------------YEQDLWDDSG----------EPEYAI 599

  Fly   543 FAQAPPPTSQA---------MVTPKPQGGGRYNNNHRGNPNNVGGANSGPRAESRSKPPRSTPSA 598
            ..|......:.         .:||:|.                    ..|..|....|||.|.|.
Zfish   600 IKQEVENFKKVHLISREQFDCLTPEPP--------------------VDPNQEVPPGPPRPTQSK 644

  Fly   599 SHIQGGNIMPIQ------ITAPIPGGMVSVVPTNIVQDPLQPAPLQQQPQQVIQQIQQQPSSSAQ 657
            .|    .:.|.:      ..||.|..|...:||.:...|                 ..:.:.:.:
Zfish   645 IH----TLFPTEALANKLFGAPDPSCMARSLPTTVPDSP-----------------SHRSARTPR 688

  Fly   658 QQQAATVQMNNTTRHYPIKSNWKGGMQKNLDKSYSGGVATHHHYTTQVQALPAHSHHLQAQQQLQ 722
            ..:...::...|.|.||:.   |.|  :.||........|.|.....::   .|...:...::.:
Zfish   689 TPRTPRLKDAQTPRFYPVV---KDG--RPLDAKTPRKRKTRHSSNPPME---CHVGWVMDSREHR 745

  Fly   723 GQTQQQHYQLASSSAASAPQVTYVTTAPAPQQPGQHQHHLVVQQ---TQPQQQQQQQQVVLQQQQ 784
            .:|...... ||.|..:|....:..| |......||..|.::::   ||....:.:::.:.::::
Zfish   746 SRTASVSSN-ASPSEGTAAMGNFGCT-PQSLPKFQHPSHELLKENGFTQHVYHKYRRRCLNERKR 808

  Fly   785 VQVQELQEAGDGV--------EHSSHAMQQVNRSSNMSASSSSSLATSMSKEPLQW--------- 832
            :.:.:.||.....        :|.:..|.:..|          .|:....||..::
Zfish   809 LGIGQSQEMNTLFRFWSFFLRDHFNRKMYEEFR----------QLSVEDGKEGYRYGLECLFRFY 863

  Fly   833 -QNRPRRRRRD------EEGGINYSPGGRVGL--------YGSSPS---NPHPQQHLMSSSTGSN 879
             ....|:.|.|      ||...:|..|...||        |..:.:   .|..|:||
Zfish   864 SYGLERKFRPDIFKDFQEETVKDYEAGQLYGLEKFWAFLKYSKTKNMEIEPKLQEHL-------- 920

  Fly   880 VQSAGGTDGGGASHRGGERQSHYNTIHD--VPPPQHRGNYKGNNYNPHYHAQHSSMASGSHHHHH 942
                                |.:..:.|  |.||...|..|          :|||...|...|..
Zfish   921 --------------------SKFRRLEDFRVDPPMEDGVRK----------RHSSSGDGRRRHPS 955

  Fly   943 HNALSSQQQQHHLTTG 958
            |....||.|.....:|
Zfish   956 HPGSRSQTQSQLQPSG 971

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Larp4B	NP_647793.1	LARP_4_5_like	269..343	CDD:153400	27/127 (21%)
Larp4B	NP_647793.1	RRM_LARP4_5_like	348..423	CDD:240876	13/85 (15%)
larp1	XP_021324942.1	LARP_1	310..382	CDD:153406	26/71 (37%)
		DM15	790..830	CDD:128927	4/39 (10%)
		DM15	831..869	CDD:128927	6/47 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586332
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840