DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Larp4B and LARP1

DIOPT Version :9

Sequence 1:	NP_647793.1	Gene:	Larp4B / 38399	FlyBaseID:	FBgn0035424	Length:	1531	Species:	Drosophila melanogaster
Sequence 2:	NP_291029.2	Gene:	LARP1 / 23367	HGNCID:	29531	Length:	1096	Species:	Homo sapiens

Alignment Length:	1132	Identity:	196/1132 - (17%)
Similarity:	333/1132 - (29%)	Gaps:	486/1132 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 QQQQQSPHPAQHLTYGHQPALSQA-TAGGSGTISGGAVGPSG----------------------- 175
            ||:::||.|.| |.....||:|.. ..||.....|||.|.:|
Human    70 QQERESPRPLQ-LPGAEGPAISDGEEGGGEPGAGGGAAGAAGAGRRDFVEAPPPKVNPWTKNALP 133

  Fly   176 ---VVVEGQDTNEYA----IMNGALGQTQDGTVVCYTTDALN--NTNLVA---LDPQPHQIV--- 225
               ..|.||...|::    ::..|:.:.:.|:.|....||:|  ....:|   :.||.|:..
Human   134 PVLTTVNGQSPPEHSAPAKVVRAAVPKQRKGSKVGDFGDAINWPTPGEIAHKSVQPQSHKPQPTR 198

  Fly   226 ------------------------------------------------------VPVQV------ 230
                                                                  ||:|:
Human   199 KLPPKKDMKEQEKGEGSDSKESPKTKSDESGEEKNGDEDCQRGGQKKKGNKHKWVPLQIDMKPEV 263

  Fly   231 --------PVQVPVPVQLPAN-----GSAD------------------PQQGSH----------N 254
                    |.:.|.|..:|||     ||..                  |:...|          :
Human   264 PREKLASRPTRPPEPRHIPANRGEIKGSESATYVPVAPPTPAWQPEIKPEPAWHDQDETSSVKSD 328

  Fly   255 AAGG---------------------------------------EEPNIP---------------- 264
            .|||                                       |.|..|
Human   329 GAGGARASFRGRGRGRGRGRGRGRGGTRTHFDYQFGYRKFDGVEGPRTPKYMNNITYYFDNVSST 393

  Fly   265 ----LDK--LKQMLATQLEYYFSRENLANDTYLLSQMDSDQYVPIYTVARFNLVRKLTNDINLIT 323
                :|:  ||..:..|:|||||.:||..|.:|..:||:|.::||..:|.|:.|:.||.||:||.
Human   394 ELYSVDQELLKDYIKRQIEYYFSVDNLERDFFLRRKMDADGFLPITLIASFHRVQALTTDISLIF 458

  Fly   324 EVLRESPNVQVDDKGLRVRPNRKRCIIILREISNNTPLDDVKALFSNESCPR------------- 375
            ..|::|..|::.|:.:|.|...::.  .|..|.:.:..|..:.|...|..||
Human   459 AALKDSKVVEIVDEKVRRREEPEKW--PLPPIVDYSQTDFSQLLNCPEFVPRQHYQKETESAPGS 521

  Fly   376 -------PISCEFAAN-----------------NSW-----------------------YIT--- 390
                   |...|..:|                 .:|                       ::|
Human   522 PRAVTPVPTKTEEVSNLKTLPKGLSASLPDLDSENWIEVKKRPRPSPARPKKSEESRFSHLTSLP 586

  Fly   391 --------FESDEDAQKAYKYL-REEVKEFQGKPIMARIKPKSFINRIQAVPKNGYRLTSPPTAN 446
                    ...|:|.|:...:| .||:::..|:                   ||.:...|...::
Human   587 QQLPSQQLMSKDQDEQEELDFLFDEEMEQMDGR-------------------KNTFTAWSDEESD 632

  Fly   447 V-FDPAGAGGATVSYAAAQQPRYL-----------YTNGAAIAAP-ASVQYSNPVLIPIPQNQFY 498
            . .|........:   ..|.|.|:           :|:.|.::|. |.|         |....||
Human   633 YEIDDRDVNKILI---VTQTPHYMRRHPGGDRTGNHTSRAKMSAELAKV---------INDGLFY 685

  Fly   499 --PGLVAGPWPPGTVAATTAHGQNFYELGGNIFTT---NPLPPQPVTAGFAQAPPPTSQAMVTPK 558
              ..|.|..:.| ..:......:||.::  |:.:.   :.|.|:|......:.||
Human   686 YEQDLWAEKFEP-EYSQIKQEVENFKKV--NMISREQFDTLTPEPPVDPNQEVPP---------- 737

  Fly   559 PQGGGRYNNNHRGNPNNVGGANSGPRAESRSKPPR--STPS---ASHIQGGNIMPIQITAPIPGG 618
                                           .|||  ..|:   |:.:.|         ||.|..
Human   738 -------------------------------GPPRFQQVPTDALANKLFG---------APEPST 762

  Fly   619 MVSVVPTNIVQDP-LQPAPLQQQPQQVIQQIQQQPSSSAQQQQAATVQMNNTTRHYPIKSNWKGG 682
            :...:||.:.:.| .:.....:.|:      ..|...|:|           |:|.||:.   |.|
Human   763 IARSLPTTVPESPNYRNTRTPRTPR------TPQLKDSSQ-----------TSRFYPVV---KEG 807

  Fly   683 MQKNLDKSYSGGVATHHHYTTQVQALPAHSHHLQAQQQLQGQTQQQHYQLASSSAASAPQVTYVT 747
              :.||........|.|   :....|.:|...:...::.:.:|.    .::||.:...|.|....
Human   808 --RTLDAKMPRKRKTRH---SSNPPLESHVGWVMDSREHRPRTA----SISSSPSEGTPTVGSYG 863

  Fly   748 TAPAPQQPGQHQHHLVVQQ---TQPQQQQQQQQVVLQQQQVQVQELQEAGDGVEHSSHAMQQVNR 809
            ..|......||..|.::::   ||....:.:::.:.:::::.:.:.||........|..::  :.
Human   864 CTPQSLPKFQHPSHELLKENGFTQHVYHKYRRRCLNERKRLGIGQSQEMNTLFRFWSFFLR--DH 926

  Fly   810 SSNMSASSSSSLATSMSKEPLQW----------QNRPRRRRRD------EEGGINYSPGGRVGL- 857
            .:.........||...:||..::          ....::.|.|      ||...:|..|...||
Human   927 FNKKMYEEFKQLALEDAKEGYRYGLECLFRYYSYGLEKKFRLDIFKDFQEETVKDYEAGQLYGLE 991

  Fly   858 -------YGSSPS---NPHPQQHLMSSSTGSNVQSAGGTDGGGASHRGGERQSHYNTIHDV---P 909
                   |..:.:   :|..|::|                            ..:..:.|.   |
Human   992 KFWAFLKYSKAKNLDIDPKLQEYL----------------------------GKFRRLEDFRVDP 1028

  Fly   910 PPQHRGNYKGNNYNPHYHAQHSSMASG 936
            |....||          |.:||.:|.|
Human  1029 PMGEEGN----------HKRHSVVAGG 1045

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Larp4B	NP_647793.1	LARP_4_5_like	269..343	CDD:153400	30/73 (41%)
Larp4B	NP_647793.1	RRM_LARP4_5_like	348..423	CDD:240876	19/146 (13%)
LARP1	NP_291029.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..356		47/286 (16%)
		Required for interaction with PABPC1. /evidence=ECO:0000269\|PubMed:29244122	77..573		90/498 (18%)
		LARP_1	404..476	CDD:153406	29/71 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	511..598		5/86 (6%)
		Required for interaction with RPTOR and for repression of mRNAs with a 5'TOP motif. /evidence=ECO:0000269\|PubMed:29244122	574..1096		102/625 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	759..861		25/130 (19%)
		Interaction with mRNA. /evidence=ECO:0000269\|PubMed:20430826, ECO:0000269\|PubMed:26206669	873..1023		24/179 (13%)
		DM15	885..925	CDD:128927	5/41 (12%)
		DM15	926..964	CDD:128927	4/37 (11%)
		Interaction with 7-methylguanosine mRNA cap structure. /evidence=ECO:0000269\|PubMed:28379136, ECO:0007744\|PDB:5V87	956..999		8/42 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1026..1096		9/30 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151755
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840