DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Larp4B and LARP4B

DIOPT Version :9

Sequence 1:	NP_647793.1	Gene:	Larp4B / 38399	FlyBaseID:	FBgn0035424	Length:	1531	Species:	Drosophila melanogaster
Sequence 2:	XP_016871476.1	Gene:	LARP4B / 23185	HGNCID:	28987	Length:	1273	Species:	Homo sapiens

Alignment Length:	795	Identity:	216/795 - (27%)
Similarity:	321/795 - (40%)	Gaps:	214/795 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 HPHQAQILAHTHVAHQQQQQQQQQTIQQHLHQQQQQQSPHPAQHLTYGHQPALSQATAGGSGTIS 167
            |....|.:..|.|:......:.......||...........|.....||     .|..|..|:.:
Human   541 HDRDGQFVPATKVSELNPNAEVWGAPVLHLEASSAADGVSAAWEEVAGH-----HADRGPQGSDA 600

  Fly   168 GGAVGPSGVVVEGQDTNEYAIMNGALGQTQDGTVVCYTTDALNNTNLVALDPQPHQIVVPVQVPV 232
            .|         :|...:|    |.||...|:....        :.|.:||.|..:.
Human   601 NG---------DGDQGHE----NAALPDPQESDPA--------DMNALALGPSEYD--------- 635

  Fly   233 QVPVPVQLPAN---GSADPQQGSHNAAGGEEPNIPLDKLKQMLATQLEYYFSRENLANDTYLLSQ 294
                  .||.|   |..:.|..|.     |:|       :::|...||:..||||||:|.||:||
Human   636 ------SLPENSETGGNESQPDSQ-----EDP-------REVLKKTLEFCLSRENLASDMYLISQ 682

  Fly   295 MDSDQYVPIYTVARFNLVRKLTNDINLITEVLRESPNVQVDDKGLRVRPNRKRCIIILREISNNT 359
            |||||||||.|||..:.::||:.|::||.||||..|.||||:||.:||||:.|||:||||||.:|
Human   683 MDSDQYVPITTVANLDHIKKLSTDVDLIVEVLRSLPLVQVDEKGEKVRPNQNRCIVILREISEST 747

  Fly   360 PLDDVKALFSNESCPRPISCEFAANNSWYITFESDEDAQKAYKYLREEVKEFQGKPIMARIKPKS 424
            |:::|:|||..::.|:.|:||||.|::|:||||::.|||:||||||||||.||||||.||||.|:
Human   748 PVEEVEALFKGDNLPKFINCEFAYNDNWFITFETEADAQQAYKYLREEVKTFQGKPIKARIKAKA 812

  Fly   425 F-INRIQAVPKNGYRLTSP-----------PTANVFDPAGAGGATVSYAAAQQ-PRYLYTNGAAI 476
            . ||..  :||||:|   |           .|:..|.|        .|:..|| |.|      ::
Human   813 IAINTF--LPKNGFR---PLDVSLYAQQRYATSFYFPP--------MYSPQQQFPLY------SL 858

  Fly   477 AAP----ASVQYSNPVLI-PIPQNQFYPGL-------VAGP------WPPGTVAATTAHGQNFYE 523
            ..|    |:..|.:|.|: |.|...|..|.       .|.|      :||.:...:.:|
Human   859 ITPQTWSATHSYLDPPLVTPFPNTGFINGFTSPAFKPAASPLTSLRQYPPRSRNPSKSH------ 917

  Fly   524 LGGNIFTTNPLPPQPVTAGFAQAP----------------PPTSQAMVT-PKPQGGGRYNNNHRG 571
                  ..:.:|......|..::|                |.|.||..| .:.|....|.....|
Human   918 ------LRHAIPSAERGPGLLESPSIFNFTADRLINGVRSPQTRQAGQTRTRIQNPSAYAKREAG 976

  Fly   572 NPNNV--GGANSGP---------------------RAESRSKPPRSTPSASHIQGGNIMPIQITA 613
             |..|  |...|.|                     .::::|..|...||.|...|.:..|
Human   977 -PGRVEPGSLESSPGLGRGRKNSFGYRKKREEKFTSSQTQSPTPPKPPSPSFELGLSSFP----- 1035

  Fly   614 PIPGGMVSVVPTNIVQDPLQPAPLQQQPQQVIQQ----------IQQQPSSSAQQQQAATVQMNN 668
            |:||...::...::.::.|....:....::.:..          :.::||..|....:||.:.:.
Human  1036 PLPGAAGNLKTEDLFENRLSSLIIGPSKERTLSADASVNTLPVVVSREPSVPASCAVSATYERSP 1100

  Fly   669 TTRHYPIKSNWKGGMQKNLDKSYSGGVATHHHYTTQVQALPAHSHHLQAQQ-QLQGQTQQQHYQL 732
            :..|.|....                ||.....|..|..||:.......:. |:.|....:...|
Human  1101 SPAHLPDDPK----------------VAEKQRETHSVDRLPSALTATACKSVQVNGAATVRTSCL 1149

  Fly   733 ASSSAASAPQVTYVTTAPAP-----------QQPGQHQHHLVVQQT---------QPQQQQQQQQ 777
            .|.:.|:..........|||           ::|...:   :.|:|         |||::|:...
Human  1150 PSCTTAARLWCEQTLRTPAPARFLITSNLELRKPSYAE---ICQRTSKEPPSSPLQPQKEQKPNT 1211

  Fly   778 VVLQQQQVQVQELQE 792
            |...:::.::.|..|
Human  1212 VGCGKEEKKLAEPAE 1226

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Larp4B	NP_647793.1	LARP_4_5_like	269..343	CDD:153400	43/73 (59%)
Larp4B	NP_647793.1	RRM_LARP4_5_like	348..423	CDD:240876	49/74 (66%)
LARP4B	XP_016871476.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151757
Domainoid	1	1.000	72	1.000	Domainoid score	I9336
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002064
OrthoInspector	1	1.000	-	-		otm40845
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22792
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3384
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.930