DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Larp4B and Larp4

DIOPT Version :9

Sequence 1:	NP_647793.1	Gene:	Larp4B / 38399	FlyBaseID:	FBgn0035424	Length:	1531	Species:	Drosophila melanogaster
Sequence 2:	NP_001271452.1	Gene:	Larp4 / 207214	MGIID:	2443114	Length:	720	Species:	Mus musculus

Alignment Length:	822	Identity:	220/822 - (26%)
Similarity:	331/822 - (40%)	Gaps:	204/822 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 LSQATAGGSGTISGGAV-------GPSGVVVEGQDTNEYAIMNGA--LGQTQDGTVVC------Y 204
            :.|.|:.|:|......|       .|.|..|.....:|.|..:|:  .|.|:....:|      |
Mouse     5 VEQVTSKGTGLNPNAKVWQEIPSGNPDGTPVTEPSWHETAATSGSHPEGHTELSEDMCKEYEVMY 69

  Fly   205 TTDALNNTNLVALDPQPHQIVVPVQVPVQVPVPVQLPANGSADPQQGSHNAAGGEEPNIPLDKLK 269
            :.......|...::.....:::                 |..|.....::.:|.....|..:.||
Mouse    70 SPSCETTRNTADVEESADGMIL-----------------GPEDLSYQLYDVSGESSSAISTEDLK 117

  Fly   270 QMLATQLEYYFSRENLANDTYLLSQMDSDQYVPIYTVARFNLVRKLTNDINLITEVLRESPNVQV 334
            :.|..|||:.||||||:.|.||:|||||||:|||:|||....::|||.:.:||.||||.||.|||
Mouse   118 ECLKKQLEFCFSRENLSKDLYLISQMDSDQFVPIWTVANMEEIKKLTTNTDLILEVLRSSPMVQV 182

  Fly   335 DDKGLRVRPNRKRCIIILREISNNTPLDDVKALFSNESCPRPISCEFAANNSWYITFESDEDAQK 399
            |:||.:|||:.||||:|||||...||:::|||||.||:||:.||||||.|::|||||:||.|||:
Mouse   183 DEKGEKVRPSHKRCIVILREIPETTPVEEVKALFKNENCPKVISCEFAHNSNWYITFQSDTDAQQ 247

  Fly   400 AYKYLREEVKEFQGKPIMARIKPKSFINRIQAVPKNGYRLTSPPTANVFDPAGAGGATVSYAAAQ 464
            |:||||||||.|||||||||||.   ||...|  ||||||....
Mouse   248 AFKYLREEVKTFQGKPIMARIKA---INTFFA--KNGYRLMDSS--------------------- 286

  Fly   465 QPRYLYTNGAAIAAPASVQYSNPVLI-PI--PQNQFYPGLVAGPWPPGTVAATTAHGQNFYELGG 526
                :||.  .|..|  .||.:||.: |:  ||......||...|.|
Mouse   287 ----MYTQ--PIQTP--TQYPSPVFMQPVYNPQQYSVYSLVPQSWSP------------------ 325

  Fly   527 NIFTTNPLPPQPVTAGFAQAPPPTSQAMVTPKPQGG--------GRYNNNHRGNPNNVGGANSG- 582
                               :|.|..:..:.|.|.|.        |.|.       .|....|.|
Mouse   326 -------------------SPAPYFETPLAPFPNGSFVNGFSSPGSYK-------TNAAAMNMGR 364

  Fly   583 PRAESRSKPP-RSTPSASHIQGGNIMPIQITAPIPGGMVSVVPTNIVQDPLQPAPLQQQPQQVIQ 646
            |..::|.||. ||:..:.|...|::                        .|...||.:...::..
Mouse   365 PFPKNRVKPHFRSSSGSEHSTEGSV------------------------SLGDGPLSRSSSRIFL 405

  Fly   647 QIQQQPSSSAQQQQ------AATVQM-NNTTRHYPIKSNWKGGMQKNLDKSYSGGVATHHHYTTQ 704
            ..:..|:.:.||:|      |..:|| .|.......::.::|..:::.|:     :.......|:
Mouse   406 SERHNPTVTGQQEQTYLPKEAPILQMEQNGDFGRGRRTLFRGRRRRDDDR-----IPRPQPAATE 465

  Fly   705 VQA--------------LPAHSHHLQAQQQLQGQTQQQHYQLASSSAASAPQVTYVTTAPAPQQP 755
            .:|              ||..|..:..:..|:.:.......:.....:...:|    :.|.|.:.
Mouse   466 AKAPTPKFDLLATNFPPLPGSSSRVPDELGLENRMSDVVKGVCREKDSEDVRV----SCPVPAED 526

  Fly   756 GQ---HQHHLVVQQTQPQQQQQQQQVVLQQQQVQVQELQEAGDGVEHSSHAMQQVNRSSNMSASS 817
            ||   ....|.:..:.|...:.......||:|.|:::.....|.:...:..:.....:....|::
Mouse   527 GQTDCTSAPLSISPSPPCTAEPPVLSTTQQEQDQMEDSAVPKDTLNPVAVPVSSPTATKPSPANT 591

  Fly   818 SSSLATSMSKEPLQWQNRPRRRRRDEEGGINYSPGGRVGLYGSSPSNPHPQQHLMSSSTGSNVQS 882
            :|...:::        |.||.....|...::|:.     :....|..|.|..........||..|
Mouse   592 ASPCTSNI--------NPPRAVALQEPRKLSYAE-----VCQKPPKEPSPVLVQPLRELRSNAVS 643

  Fly   883 AGGTDGGGASHRGGERQSHYNTIHDVPPPQ----HRGNYKGN 920
            ....:..||..:..|:.      |:.|..:    |.| ::||
Mouse   644 PTRNEENGAPEKPVEKP------HEKPETRASKDHSG-FRGN 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Larp4B	NP_647793.1	LARP_4_5_like	269..343	CDD:153400	45/73 (62%)
Larp4B	NP_647793.1	RRM_LARP4_5_like	348..423	CDD:240876	55/74 (74%)
Larp4	NP_001271452.1	Interaction with PABPC1. /evidence=ECO:0000250\|UniProtKB:Q71RC2	13..22		1/8 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..56		7/33 (21%)
		Interaction with the poly-A tract of mRNA. /evidence=ECO:0000250\|UniProtKB:Q71RC2	108..300		121/225 (54%)
		LARP_4	117..191	CDD:153404	45/73 (62%)
		RRM_LARP4	196..272	CDD:241151	55/78 (71%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	364..399		11/58 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	438..471		4/37 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	530..563		6/32 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	577..602		3/32 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	616..720		15/75 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841865
Domainoid	1	1.000	72	1.000	Domainoid score	I9284
eggNOG	1	0.900	-	-		E1_KOG2591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002064
OrthoInspector	1	1.000	-	-		otm42917
orthoMCL	1	0.900	-	-		OOG6_107958
Panther	1	1.100	-	-	LDO	PTHR22792
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3384
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.820