DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Larp4B and larp-5

DIOPT Version :9

Sequence 1:	NP_647793.1	Gene:	Larp4B / 38399	FlyBaseID:	FBgn0035424	Length:	1531	Species:	Drosophila melanogaster
Sequence 2:	NP_491209.3	Gene:	larp-5 / 171942	WormBaseID:	WBGene00004147	Length:	760	Species:	Caenorhabditis elegans

Alignment Length:	1100	Identity:	217/1100 - (19%)
Similarity:	345/1100 - (31%)	Gaps:	466/1100 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   168 GGAVGPSGVVVEGQDTNEYAIMNGALGQTQDGTVVCYTTDALNNTNLVALDPQPHQIVVPVQVPV 232
            |.:||.|.....|  |:.....:||.|..|...:. |..:....::|:.:.|||..
Worm    55 GSSVGTSNAHSPG--TSPSTSASGASGIPQPPPLP-YWFNRECKSSLMMIGPQPPG--------- 107

  Fly   233 QVPVPVQLPANGSADPQQGSHN---AAGGEEPNIPLDKLKQMLATQLEYYFSRENLANDTYLLSQ 294
                    |::|.:.|...|.|   .|....|.:..:::||:|..|||||||||||::|.||..|
Worm   108 --------PSSGMSMPSSSSTNQFVPAVPPPPPLSREEIKQLLKNQLEYYFSRENLSSDRYLKCQ 164

  Fly   295 MDSDQYVPIYTVARFNLVRKLTNDINLITEVLRESPNVQVDDKGLRVRPNRKRCIIILREISNNT 359
            ||||.||||..:|.|..:.:||.|::||.|.|:||.||::|:|..:||...||.::::|||. .|
Worm   165 MDSDNYVPINVLAGFPKIMRLTTDVDLIVEALKESTNVELDEKFEKVRAITKRKVMLIREIP-ET 228

  Fly   360 PLDDVKALFSNESCPRPISCEFAANNSWYITFESDEDAQKAYKYLREEVKEFQGKPIMARIKPKS 424
            ..::|..|.::.  |.....::..|:.||:|:|::.|||.||..::....|...|.:.||||
Worm   229 HREEVVKLIADG--PPYTDLQYGVNDGWYVTYENELDAQVAYVAVQHRKNEITQKQVCARIK--- 288

  Fly   425 FINRIQAVPKNGYRLTSPPTANVFDPAGAGGATVSYAAAQQPRYLYTNGAAIAAPASVQYSNPVL 489
                                                          |.|.:..||
Worm   289 ----------------------------------------------TCGPSTFAP---------- 297

  Fly   490 IPIPQNQFYPGLVAGPWPPGTVAATTAHGQNFYELGGNIFTTNPLPPQPVTAGFAQAPPPTSQAM 554

Worm   298 ----------------------------------------------------------------- 297

  Fly   555 VTPKPQGGGRYNNNHRGNPNNVGGANSGPRAESRSKPPRSTPSASHIQGGNIMPIQITAPIPGGM 619
                                                ||..||   |.:.|
Worm   298 ------------------------------------PPEETP---HSENG--------------- 308

  Fly   620 VSVVPTNIVQDPLQPAPLQQQPQQVIQQIQQQPSSSAQQQQAATVQMNNTTRHY---PIKSNWKG 681
                                         |.....:.:|......::..|...|   |:
Worm   309 -----------------------------QMTTLGNGEQGTVHLRELGQTLSDYGFVPV------ 338

  Fly   682 GMQKNLDKSYSGG--VATHHHYTTQVQALPAHSHHLQAQQQLQGQTQQQHYQLASSSAASAPQVT 744
                   .:|..|  :::|..|.|..                        ::.:.:|.:..|.:
Worm   339 -------ATYRPGDPISSHFEYITPT------------------------FRFSGNSLSYNPPM- 371

  Fly   745 YVTTAPAPQQPGQHQHHLVVQQTQPQQQQQQQQVVLQQQQVQVQELQEAGDGVEHSSHAMQQVNR 809
                .|.|..|.||..       |.||||||||..|         ||.......:.|........
Worm   372 ----PPVPPLPPQHHQ-------QHQQQQQQQQPPL---------LQNTPQPYYYGSSVSTTPRN 416

  Fly   810 SSNMSASSSSSLATSMSKEPLQWQNRPRRRRRDEEGGINYSPGGRVGLYGSSPSNPHPQQHLMSS 874
            ...||.:||:|..|:.|    .:.||...|    .||..|        |.|           .||
Worm   417 YDEMSTASSNSTHTTTS----NYNNRNGSR----NGGNQY--------YES-----------RSS 454

  Fly   875 STGSNV-QSAGGTDGGGASHRGGE---RQSHYNTIHDVPPPQHRGNYKGNNYNPHYHAQHSSMAS 935
            .:.||. :|.||.:||...:...|   |||:.:          .|.::|||.|       .:..:
Worm   455 FSNSNEWRSRGGGNGGRFQNNYSENNGRQSNGS----------NGRWRGNNRN-------GATTN 502

  Fly   936 GSHHHHHHNALSSQQQQHHLTTGTGQQGSGHHYHHHHHHNSIGSNVGNSGGLGVSSGGSGGGGSG 1000
            |..:..|:|      :|:|...|. |:.:|.:.||:|:.|
Worm   503 GYGYQQHNN------RQNHYQNGQ-QRENGENGHHNHYQN------------------------- 535

  Fly  1001 GGSGSNSLSGGSNERGIHHSSLGYQGHQHQHQQQQQQQQQQQQQQPAAPVQPPQFDLEDAAFPPL 1065
             |..|||               .:.|:..|.:|::||......:                   |.
Worm   536 -GQSSNS---------------WWSGNDGQTRQRKQQHNGYNNR-------------------PT 565

  Fly  1066 PATSATAPHTPQATGGASLHNSTTSSSSSTGLGQKQTLHQQQQQAPQQHQVLSSSV------ESA 1124
            .::|:::..:.:.....::...|.|.||        |..|...:.|:.|....:.:      .:.
Worm   566 VSSSSSSSTSSKYFSPDAVETPTNSGSS--------TPPQTSVRNPKYHVPTPTDLPPPPVWPAP 622

  Fly  1125 GGDEQRSSNQQGIETSNIHLANSSTANNWVENRLSDVVRTGGGGGGGGKGKARKDNRHP---QGQ 1186
            ..|.:|.|::....|:.  ..|:.|.:..|   ...|:|.     ...:.||.::...|   :..
Worm   623 NFDRRRKSSETSFTTNT--TTNTLTPSTPV---TPPVLRP-----AFSESKAPQEPSKPVETKEN 677

  Fly  1187 NQPHMAPNYQQHQP------------------------RNPPV----SPTPALGAEYGIQ 1218
            |:|.:..::...:|                        |:|||    ||.||..:.:..:
Worm   678 NKPALTDDFPLPEPLPQKPKIETNHHSAVEKDAEKIKVRSPPVVVASSPAPAAPSPFSFE 737

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Larp4B	NP_647793.1	LARP_4_5_like	269..343	CDD:153400	42/73 (58%)
Larp4B	NP_647793.1	RRM_LARP4_5_like	348..423	CDD:240876	23/74 (31%)
larp-5	NP_491209.3	LARP_4_5_like	139..213	CDD:153400	42/73 (58%)
larp-5	NP_491209.3	RRM_LARP4_5_like	218..290	CDD:240876	23/123 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161042
Domainoid	1	1.000	108	1.000	Domainoid score	I4040
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002064
OrthoInspector	1	1.000	-	-		oto17630
orthoMCL	1	0.900	-	-		OOG6_107958
Panther	1	1.100	-	-	LDO	PTHR22792
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3384
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.960