DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Larp4B and LARP4

DIOPT Version :9

Sequence 1:	NP_647793.1	Gene:	Larp4B / 38399	FlyBaseID:	FBgn0035424	Length:	1531	Species:	Drosophila melanogaster
Sequence 2:	XP_011536131.1	Gene:	LARP4 / 113251	HGNCID:	24320	Length:	732	Species:	Homo sapiens

Alignment Length:	835	Identity:	225/835 - (26%)
Similarity:	344/835 - (41%)	Gaps:	209/835 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 QQSPHPAQHLTYGH------------QPALSQATAGGSGTISG-------GAVGPSGVVVEGQD- 182
            |..|.|.|..:.|.            .|..:.||....||.|.       ....|.|.....:|
Human     8 QACPTPQQVASKGTGLNPNAKVWQEIAPGNTDATPVTHGTESSWHEIAATSGAHPEGNAELSEDI 72

  Fly   183 TNEYAIM-NGALGQTQDGTVVCYTTDALNNTNLVALDPQPHQIVVPVQVPVQVPVPVQLPANGSA 246
            ..||.:| :.:...|::.|.:..:||.:              |:.|..:..|:
Human    73 CKEYEVMYSSSCETTRNTTGIEESTDGM--------------ILGPEDLSYQI------------ 111

  Fly   247 DPQQGSHNAAGGEEPNIPLDKLKQMLATQLEYYFSRENLANDTYLLSQMDSDQYVPIYTVARFNL 311
                  ::.:|.....:..:.||:.|..|||:.||||||:.|.||:|||||||::||:|||....
Human   112 ------YDVSGESNSAVSTEDLKECLKKQLEFCFSRENLSKDLYLISQMDSDQFIPIWTVANMEE 170

  Fly   312 VRKLTNDINLITEVLRESPNVQVDDKGLRVRPNRKRCIIILREISNNTPLDDVKALFSNESCPRP 376
            ::|||.|.:||.||||.||.||||:||.:|||:.||||:|||||...||:::||.||.:|:||:.
Human   171 IKKLTTDPDLILEVLRSSPMVQVDEKGEKVRPSHKRCIVILREIPETTPIEEVKGLFKSENCPKV 235

  Fly   377 ISCEFAANNSWYITFESDEDAQKAYKYLREEVKEFQGKPIMARIKPKSFINRIQAVPKNGYRLTS 441
            ||||||.|::|||||:||.|||:|:||||||||.|||||||||||.   ||...|  ||||||..
Human   236 ISCEFAHNSNWYITFQSDTDAQQAFKYLREEVKTFQGKPIMARIKA---INTFFA--KNGYRLMD 295

  Fly   442 PPTANVFDPAGAGGATVSYAAAQQPRYLYTNGAAIAAPASVQYSNPVLIPIPQNQFYPGLVAGPW 506
                         .:..|:....|.:|        |:|..:|   ||..|..|...| .:|...|
Human   296 -------------SSIYSHPIQTQAQY--------ASPVFMQ---PVYNPHQQYSVY-SIVPQSW 335

  Fly   507 PPGTVAATTAHGQNFYELGGNIFTTNPLPPQPVTAGFAQAPPPTSQAMVTPKPQGGGRYNNNHRG 571
            .|                       ||.|       :.:.|       :.|.|.|......|..|
Human   336 SP-----------------------NPTP-------YFETP-------LAPFPNGSFVNGFNSPG 363

  Fly   572 N-PNNVGGANSG-PRAESRSKPP-RSTPSASHIQGGNIMPIQITAPIPGGMVSVVPT-NIVQDPL 632
            : ..|....|.| |..::|.||. ||:..:.|...|::       .:..|.::...: |...:..
Human   364 SYKTNAAAMNMGRPFQKNRVKPQFRSSGGSEHSTEGSV-------SLGDGQLNRYSSRNFPAERH 421

  Fly   633 QPAPLQQQPQQVIQQIQQQPSSSAQQQQAATVQMNNTTRHYPIKSNWKGGMQKNLDKSYSGGVAT 697
            .|.....|.|..:    |:.:|:.|.:|.........|.       ::|..::..|:     ::.
Human   422 NPTVTGHQEQTYL----QKETSTLQVEQNGDYGRGRRTL-------FRGRRRREDDR-----ISR 470

  Fly   698 HHHYTTQVQA--------------LPAHSHHLQAQQQLQGQ---------TQQQHYQLASSSAAS 739
            .|..|.:.:|              ||..|..:..:..|:.:         .::.:.:|..|....
Human   471 PHPSTAESKAPTPKFDLLASNFPPLPGSSSRMPGELVLENRMSDVVKGVYKEKDNEELTISCPVP 535

  Fly   740 APQVTYVTTAPAPQQPGQHQHHLVVQQTQPQQQQQQQQVVLQQQQVQVQELQEAGDGVEHSSHAM 804
            |.:.|..|:|   ||       |.:..:.|...:.......||::..:::.....||:..::..:
Human   536 ADEQTECTSA---QQ-------LNMSTSSPCAAELTALSTTQQEKDLIEDSSVQKDGLNQTTIPV 590

  Fly   805 QQVNRSSNMSASSSSSLATSMSKEPLQWQNRPRRRRRDEEGGINYSPGGRVGLYGSSPSNP---- 865
            ...:.:....||::|....:::.........||:        ::|:.     :....|..|
Human   591 SPPSTTKPSRASTASPCNNNINAATAVALQEPRK--------LSYAE-----VCQKPPKEPSSVL 642

  Fly   866 -HPQQHLMSSSTGSNVQSAGGTDGGGASHRGGERQSHYNTIHDVPPPQHRGNYKG 919
             .|.:.|.     |||.|....:..||.....|:.      |:.|..:...:|.|
Human   643 VQPLRELR-----SNVVSPTKNEDNGAPENSVEKP------HEKPEARASKDYSG 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Larp4B	NP_647793.1	LARP_4_5_like	269..343	CDD:153400	45/73 (62%)
Larp4B	NP_647793.1	RRM_LARP4_5_like	348..423	CDD:240876	53/74 (72%)
LARP4	XP_011536131.1	LARP_4	128..202	CDD:153404	45/73 (62%)
LARP4	XP_011536131.1	RRM_LARP4	207..283	CDD:241151	53/78 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151760
Domainoid	1	1.000	72	1.000	Domainoid score	I9336
eggNOG	1	0.900	-	-		E1_KOG2591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002064
OrthoInspector	1	1.000	-	-		otm40845
orthoMCL	1	0.900	-	-		OOG6_107958
Panther	1	1.100	-	-	LDO	PTHR22792
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3384
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.730