DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Larp4B and LOC100332095

DIOPT Version :9

Sequence 1:	NP_647793.1	Gene:	Larp4B / 38399	FlyBaseID:	FBgn0035424	Length:	1531	Species:	Drosophila melanogaster
Sequence 2:	XP_009295225.1	Gene:	LOC100332095 / 100332095	-ID:	-	Length:	787	Species:	Danio rerio

Alignment Length:	898	Identity:	250/898 - (27%)
Similarity:	355/898 - (39%)	Gaps:	257/898 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 GHQPALSQATAGGSGT-----ISGGAVGPSGVVV--EGQDTNEYAIMNGALGQTQ-----DGTVV 202
            |.:|.|.:....|..|     |:.|..|.|||:|  :|...|..|.:...:..||     ||||.
Zfish     6 GGEPQLQEEAEPGPETRGEDEIAPGTGGDSGVMVTAKGAGLNPNAKVWQEIPATQTEAPVDGTVA 70

  Fly   203 ------CYTTDAL--------------NNTNLV------ALDPQPHQIVVPVQVPVQVPVPVQLP 241
                  |...|..              |:|:..      .:|| |.|.....:......|..:||
Zfish    71 SPWSQNCTAEDTAVGKLYTPGFSTLEDNSTSATVVGVVNGMDP-PDQSFPVCERITATNVDSKLP 134

  Fly   242 ANGSADPQQGSHNAAGGEEPNIPLDKLKQMLATQLEYYFSRENLANDTYLLSQMDSDQYVPIYTV 306
                             ||..:..:.|::.|..:||:.||||||:.|.||:|||||||:|||:|:
Zfish   135 -----------------EEQPVSEESLRESLKKELEFCFSRENLSKDLYLISQMDSDQFVPIWTI 182

  Fly   307 ARFNLVRKLTNDINLITEVLRESPNVQVDDKGLRVRPNRKRCIIILREISNNTPLDDVKALFSNE 371
            |....::.||.|::||.:|||.||.||||:||.:||||.|||||||||:...||:::|:|||.|:
Zfish   183 ASMEGIKVLTTDMDLILDVLRSSPMVQVDEKGEKVRPNHKRCIIILREVPETTPVEEVEALFKND 247

  Fly   372 SCPRPISCEFAANNSWYITFESDEDAQKAYKYLREEVKEFQGKPIMARIKPKSFINRIQAVPKNG 436
            :||:.||.|||.||:|||||:||.|||:||:|||||||.|||||||||||.   ||...|  |||
Zfish   248 NCPKVISVEFAHNNNWYITFQSDTDAQQAYRYLREEVKTFQGKPIMARIKA---INTFFA--KNG 307

  Fly   437 YRLTSPPTANVFDPAGAGGATVSYAAAQQPRYLYTNGAAIAAPASVQYSNPVLI-PI--PQNQFY 498
            ||                    |...:..|:..:|         ..||::|:.: |:  ||.| |
Zfish   308 YR--------------------SLDCSVYPQQSHT---------PPQYNSPLFMQPVYSPQQQ-Y 342

  Fly   499 P--GLVAGPWPP----------------GTVAATTAHGQNFYELGGNI------FTTNPLP---- 535
            |  |:|...|.|                |.|...::.|.  |:.|.|.      |:.|.:|
Zfish   343 PLYGIVPPTWTPSPTPYFETPLAPFPNSGFVNGFSSPGH--YKTGSNSLNLSRPFSRNRVPLYSR 405

  Fly   536 ------------PQ------------PVT-----AGFAQAPPPTSQAMVTPKPQGGGRYNNNHRG 571
                        ||            ||.     :|.....||:|...|.........:.:....
Zfish   406 KNVINAFRNHVKPQTRTNDGLSSTVSPVALVDGLSGLHSPQPPSSAGPVLSSADLNSSFPHLASN 470

  Fly   572 NPNNVGG-ANSGPRAESRSKPPRSTPSASHIQGGNIMPIQITAPIPGGMVSVVPT--NIVQDPLQ 633
            .|.:.|. |..|.|...|....|....            :.|.|||...|.|.|.  ::......
Zfish   471 EPTDDGTMAGRGRRTTYRGTRRRRDDD------------RTTRPIPLSQVKVPPPKFDLAASNFP 523

  Fly   634 PAP-----------LQQQPQQVIQQIQQQPSSSAQQQQAATVQMNNTTRHYPIKSNWKGGMQKNL 687
            |.|           |:.:...|::.:.::....:.::  :||.....:            .::::
Zfish   524 PLPGCSASPQGEPVLENRLSDVVRGLNREKQQDSNKE--STVSPTGPS------------SEESV 574

  Fly   688 DKSYSGGVATHHHYTTQVQALPAH--------SHHLQAQQQLQGQTQQQHYQ--LASSSAASAPQ 742
            .|.           |..|..:.||        |:||:.:.:   :.:...|:  ..:|:..:|.|
Zfish   575 SKP-----------TQPVAKMNAHVPDPVTPSSNHLEKKPE---KVEPPVYKEPPVTSAPIAAVQ 625

  Fly   743 VTYVTTAPAPQ-QPGQHQHHLVVQQTQPQQQQQQQQVVLQQQQVQVQELQEAGDGVEHSSHAMQQ 806
            .|...|||.|: ||...........|.|......:...|...:|..:..::.......||
Zfish   626 PTPAPTAPGPKLQPSSALPAAPQSNTAPSSTPALEPRKLSYAEVCQRPPKDPPPPASSSS----- 685

  Fly   807 VNRSSNMSASSSSSLATSMSKE----PLQWQNRPRRRRRDEEGGINYSPGGRVGLYGSSPSNPHP 867
               .:|.||.....|..:..:|    |...|.||:     |.||...:..||          |..
Zfish   686 ---PNNASAQPLRELRVNKVEEQASSPASKQERPQ-----ESGGNCKAREGR----------PAR 732

  Fly   868 QQHLMSSSTGSNVQSAGGTD----------GGGASHRGGERQSHYNTIHDVPP 910
            .....|.|.|....|.||..          |...|.:||.|  |.....::||
Zfish   733 DSQSFSRSNGPPRSSTGGFKLREQQRRPPFGHRGSPQGGSR--HAGKEQNIPP 783

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Larp4B	NP_647793.1	LARP_4_5_like	269..343	CDD:153400	41/73 (56%)
Larp4B	NP_647793.1	RRM_LARP4_5_like	348..423	CDD:240876	53/74 (72%)
LOC100332095	XP_009295225.1	LARP_4	145..219	CDD:153404	41/73 (56%)
LOC100332095	XP_009295225.1	RRM_LARP4	224..300	CDD:241151	53/78 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586337
Domainoid	1	1.000	191	1.000	Domainoid score	I3180
eggNOG	1	0.900	-	-		E1_KOG2591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	263	1.000	Inparanoid score	I3073
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002064
OrthoInspector	1	1.000	-	-		otm24760
orthoMCL	1	0.900	-	-		OOG6_107958
Panther	1	1.100	-	-	LDO	PTHR22792
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3384
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.870