Protein Alignment nSMase and smpd2b

DIOPT Version :9

• Sequence 1: NP_647790.1
• Gene: nSMase / 38396
• FlyBaseID: FBgn0035421
• Length: 442
• Species: Drosophila melanogaster
• Sequence 2: XP_001338369.2
• Gene: smpd2b / 797914
• ZFINID: ZDB-GENE-130530-640
• Length: 436
• Species: Danio rerio
• Alignment Length: 431
• Identity: 133/431 - (30%)
• Similarity: 205/431 - (47%)
• Gaps: 70/431 - (16%)

  Fly     4 LELNILTLNIWGIPYVSSDRRPRIDAICKELASGKYDIVSLQEVWAQEDSELLQKGTEAVLPHSH 68
            ::..:|:||.|||.|:|..|:.|...|.:.|...:.|:..|||||.::|...|:|....|.||||
Zfish     7 IKFRVLSLNCWGIQYLSKKRQERFVLIGELLNQEELDVALLQEVWCEKDFLYLKKKLSTVYPHSH 71

  Fly    69 YFHSGVMGAGLLVLSKYPILGTLFHAWSVNGYFHRIQHADWFGGKGVGLCRILVGGQMVHLYNAH 133
            ||.||..|:||.|.|::.|.....:.:|:|||.:..||.||||||.||...:.:.|..||::..|
Zfish    72 YFKSGFFGSGLAVFSRHQIHDAFLYRYSLNGYPYMAQHGDWFGGKAVGKVLLNISGLKVHVFVTH 136

  Fly   134 LHAEYDNANDEYKTHRVIQAFDTAQFIEATRGNSALQILAGDLNAQPQDISYKVLL-YT------ 191
            |||||....|.|.:|||:||::..|||..|...:.:.||.||||..|.|:..::|. ||
Zfish   137 LHAEYCREKDSYLSHRVVQAWELQQFIRHTSAGADVVILGGDLNMHPDDLGTRLLRNYTGLQDSF 201

  Fly   192 --SKMLDSCDSDSFRTNECEHNSYTSKQARERNPLGIRIDHIFVRGGDHVNA---EIAEYKLPFP 251
              :...|.|:......:|   |.:|..........|||||:|..:|...|:.   .::..|.|
Zfish   202 TEAATFDGCEGGLTHISE---NPFTLADGLAPFGGGIRIDYIMFKGSGEVDVSCESLSTTKGP-- 261

  Fly   252 ERVPGEKFSFSDHEAVMAKLKLFKLEPRSEEPVATIEVNCLVEDGETCSVREVGAGDALTGEDDQ 316
              |||:.|.:|||||:.|:   |...|              .:.|..|:  |..:|..|   ||
Zfish   262 --VPGQPFPYSDHEALTAQ---FLFTP--------------TKKGNKCA--ENKSGCVL---DD- 301

  Fly   317 SSQHQPEIQCNGSSTSIQSMPAARTAALLEALALCDASLLQLNTDRILYYSAATFLFVLLVLLVE 381
                .||:        :.::..|||.  ::....|        ::.:.|.:|.|.:..|::|::|
Zfish   302 ----LPEL--------VNTVNEARTE--VKVGLHC--------SEGMRYTAARTGIMGLVLLILE 344

  Fly   382 FTA------PVGMRTIFLLLKFIVFGVILFCVFMASIWNYM 416
            ...      .:|....|....|.:.|.:.|.:.::::..|:
Zfish   345 LVIAAIPLFALGAEQPFPKATFYLLGALCFAILLSTLMLYI 385

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nSMase	NP_647790.1	EEP	12..267	CDD:294334	102/266 (38%)
smpd2b	XP_001338369.2	EEP	11..279	CDD:294334	106/277 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590621
Domainoid	1	1.000	178	1.000	Domainoid score	I3522
eggNOG	1	0.900	-	-		E1_KOG3873
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31129
Inparanoid	1	1.050	195	1.000	Inparanoid score	I3811
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D573534at33208
OrthoFinder	1	1.000	-	-		FOG0003990
OrthoInspector	1	1.000	-	-		otm24857
orthoMCL	1	0.900	-	-		OOG6_105043
Panther	1	1.100	-	-	LDO	PTHR12393
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2164
SonicParanoid	1	1.000	-	-		X2751
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.790