Protein Alignment nSMase and smpd2a

DIOPT Version :9

• Sequence 1: NP_647790.1
• Gene: nSMase / 38396
• FlyBaseID: FBgn0035421
• Length: 442
• Species: Drosophila melanogaster
• Sequence 2: NP_001025390.2
• Gene: smpd2a / 567548
• ZFINID: ZDB-GENE-051014-1
• Length: 421
• Species: Danio rerio
• Alignment Length: 420
• Identity: 134/420 - (31%)
• Similarity: 200/420 - (47%)
• Gaps: 69/420 - (16%)

  Fly     6 LNILTLNIWGIPYVSSDRRPRIDAICKELASGKYDIVSLQEVWAQEDSELLQKGTEAVLPHSHYF 70
            |.:.:||.|||.::|.....|.:.|.:.|...::||..|||||::.|...|::......|::|||
Zfish     9 LRVFSLNCWGIRFLSKLCAQRYEMIGELLGREQHDIALLQEVWSERDFLFLKRKLSCSHPYTHYF 73

  Fly    71 HSGVMGAGLLVLSKYPILGTLFHAWSVNGYFHRIQHADWFGGKGVGLCRILVGGQMVHLYNAHLH 135
            .|||:|:||.|.||:.|...|.:.:|:|||.:.:.|.||||||..||..:.|.|...|:|..|||
Zfish    74 KSGVIGSGLAVFSKHRIQDALLYQYSLNGYPYMLSHGDWFGGKAAGLVIVEVFGLKAHVYVTHLH 138

  Fly   136 AEYDNANDEYKTHRVIQAFDTAQFIEATRGNSALQILAGDLNAQPQDISYKVLLYTSKMLDSCDS 200
            |||..|.|.|..||::|:::..||:..|...:.|.||.||||..|||:..: ||.:...|..|.:
Zfish   139 AEYSRAQDGYLPHRIVQSWELQQFVRHTSHGADLVILGGDLNMHPQDLGNR-LLRSHTGLRDCYT 202

  Fly   201 DSFRTNECE-------HNSYTSKQARERNPLGIRIDHIFVRGGDHVNAEIAEYKLPFPERVPGEK 258
            ::.:.:.||       :|.:|.||.......|||||:|.::|...|:.: .|........|..:.
Zfish   203 ETDKFDGCEDGHTLIANNHFTKKQDLIPFEKGIRIDYILIKGSQRVSVK-CESLSTTKGSVSDKP 266

  Fly   259 FSFSDHEAVMAKLKLFKLE------PRSEEPVATIEVNCLVEDGETCSVREVGAGDALTGEDDQS 317
            |.:|||||:||.|.|...:      |.|::.....|...:|::|       :|..:||..
Zfish   267 FPYSDHEALMADLNLLSSQDCTDAPPASDQMDVVSEARAVVKEG-------LGKTEALRD----- 319

  Fly   318 SQHQPEIQCNGSSTSIQSMPAARTAALLEALALCDASLLQLNTDRILYYSAATFLFVLLVLLVEF 382
                            :|:.......||..|.||.:|...        :|||.||
Zfish   320 ----------------RSLHLMFAGLLLLLLVLCSSSFFS--------FSAAGFL---------- 350

  Fly   383 TAPVGMRTIFLLLKFIVFGVILFCVFMASI 412
                |...:|:||.    |.:|:.:|...|
Zfish   351 ----GAVCVFILLS----GALLYMLFTTHI 372

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nSMase	NP_647790.1	EEP	12..267	CDD:294334	99/261 (38%)
smpd2a	NP_001025390.2	EEP	11..279	CDD:294334	103/269 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590622
Domainoid	1	1.000	178	1.000	Domainoid score	I3522
eggNOG	1	0.900	-	-		E1_KOG3873
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31129
Inparanoid	1	1.050	195	1.000	Inparanoid score	I3811
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D573534at33208
OrthoFinder	1	1.000	-	-		FOG0003990
OrthoInspector	1	1.000	-	-		otm24857
orthoMCL	1	0.900	-	-		OOG6_105043
Panther	1	1.100	-	-	O	PTHR12393
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2164
SonicParanoid	1	1.000	-	-		X2751
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.790