Protein Alignment nSMase and css1

DIOPT Version :9

• Sequence 1: NP_647790.1
• Gene: nSMase / 38396
• FlyBaseID: FBgn0035421
• Length: 442
• Species: Drosophila melanogaster
• Sequence 2: NP_001342880.1
• Gene: css1 / 2541113
• PomBaseID: SPBC32F12.01c
• Length: 424
• Species: Schizosaccharomyces pombe
• Alignment Length: 462
• Identity: 126/462 - (27%)
• Similarity: 197/462 - (42%)
• Gaps: 114/462 - (24%)

  Fly     5 ELNILTLNIWGIPYVSSDRRPRIDAICKELASGKYDIVSLQEVWAQEDSELLQKGTEAVLPHSHY 69
            ||.:|:.|.||:.:||..|..|:.|:.::||...||||.|||||:..|.:.::......|.:|.:
pombe     8 ELRVLSFNCWGLRFVSKYRTERLKAVGEKLAKCDYDIVLLQEVWSIYDFQEIRNLVSCNLVYSRF 72

  Fly    70 FHSGVMGAGLLVLSKYPILGTLFHAWSVNGYFHRIQHADWFGGKGVGLCRIL-VGGQMVHLYNAH 133
            |||..|||||.:.||:||:.:..:.:.:||........||:.||||....:. ..|:::.|:|.|
pombe    73 FHSAAMGAGLAMFSKFPIIESSMNKYPLNGRPQAFWRGDWYVGKGVATASLQHPSGRIISLFNTH 137

  Fly   134 LHAEYDNANDEYKTHRVIQAFDTAQFIEATRGNSALQILAGDLNAQPQDISYKVL---------- 188
            |||.|....|.|..||:.||:..::.:.|......:.|.|||.|.||..:.::::
pombe   138 LHAPYGKGADTYLCHRLSQAWYISKLLRAAVQRGHIVIAAGDFNIQPLSVPHEIITSYGLVNDAW 202

  Fly   189 --LYTSK---------MLD---------SCDSDSFRTNECEHNSYTSKQARERNPLGIRIDHIFV 233
              :|..:         |.|         :|||   |.|....| .:||...:.  :..|:|::|
pombe   203 LSVYPDQVEHPPNRFSMNDKELVEIAGTTCDS---RLNTWREN-ISSKDMDDF--VAKRLDYVF- 260

  Fly   234 RGGDH--VNAEIAEYKLPFPERVPGEKFSFSDHEAVMAKLKLFKLEPRSEEPVATIEVNCLVEDG 296
                |  ...|....|:.|.||||....|:|||.|:...|.: ||:|   .||....|:..:.|.
pombe   261 ----HSPSTCEAKNAKVVFLERVPKLDCSYSDHFAIETVLSI-KLQP---IPVQETRVSYSIIDD 317

  Fly   297 ETCSVREVGAGDALTGEDDQSSQHQPEIQCNGSSTSIQSMPAARTAALL----------EALALC 351
            ......:..|.:.|         |.                ..|.|.||          .|:|.|
pombe   318 TLGITYQYMARERL---------HM----------------RLRIAHLLISIPLIIGVHVAIAWC 357

  Fly   352 DASLLQLNTDRILYYSAATFLFVLLVLLVEFTAPVGMRTIFLLLKFIVFGVILFCVFMASIWNYM 416
            |.:.|:                   |:::.|       |:.|.:..:|.|   ||:.:  ::...
pombe   358 DPAWLK-------------------VIILFF-------TVMLTIAAVVNG---FCIGL--LFGRW 391

  Fly   417 ERNGVLQ 423
            |.||:|:
pombe   392 EFNGLLE 398

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nSMase	NP_647790.1	EEP	12..267	CDD:294334	90/287 (31%)
css1	NP_001342880.1	EEP	11..296	CDD:321002	92/295 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	129	1.000	Domainoid score	I1352
eggNOG	1	0.900	-	-		E1_KOG3873
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	140	1.000	Inparanoid score	I1371
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003990
OrthoInspector	1	1.000	-	-		oto101313
orthoMCL	1	0.900	-	-		OOG6_105043
Panther	1	1.100	-	-	LDO	PTHR12393
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2164
SonicParanoid	1	1.000	-	-		X2751
TreeFam	1	0.960	-	-
	12	11.850