DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hob and KIAA0100

DIOPT Version :9

Sequence 1:	NP_001303402.1	Gene:	hob / 38395	FlyBaseID:	FBgn0035420	Length:	2300	Species:	Drosophila melanogaster
Sequence 2:	NP_055495.2	Gene:	KIAA0100 / 9703	HGNCID:	28960	Length:	2235	Species:	Homo sapiens

Alignment Length:	2446	Identity:	767/2446 - (31%)
Similarity:	1194/2446 - (48%)	Gaps:	370/2446 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 MLQLLLFCL-ALFIFVYWVLPTGISWYLVKRFRVKVRIGRISLPYLSLKNVHI--SKSGFSVQIE 63
            :|.|||..| |||:..:.|:.....| ..::.:.:::||  |..:..::||.:  .:...:|:|:
Human     8 LLVLLLVALSALFLGRWLVVRLATKW-CQRKLQAELKIG--SFRFFWIQNVSLKFQQHQQTVEID 69

  Fly    64 EVCLRSSFFTTEVTKLLSIYIRDIRINKDIHSRQDDSYDQDSYELRRTQTLAGKASEAKGVPDFR 128
            .:.:.|...:.::...:::...::||..|               |::...|:...|::.||....
Human    70 NLWISSKLLSHDLPHYVALCFGEVRIRTD---------------LQKVSDLSAPFSQSAGVDQKE 119

  Fly   129 QTKVPASIITFAQFMAVHVNNISVVLMNNDFDPG-WFIHATAKELHLDGSIVQNARVLLVNAALS 192
            .:..|:.:..|.|..::||:.|:::::..|.... |.|..:.....||    .:.:.|:...:|.
Human   120 LSFSPSLLKIFCQLFSIHVDAINIMVLKVDTSESLWHIQISRSRFLLD----SDGKRLICEVSLC 180

  Fly   193 EAQAKMLRHCSSRRQSLENLNKIRPCLGEVS--FDMTLDASLFAQGPLSMDTLSLVINNAKSVIH 255
            :..:|:|     :...||:     .||.|:|  .|:.|...:.::   .:..:::.:....:.:|
Human   181 KINSKVL-----KSGQLED-----TCLVELSLALDLCLKVGISSR---HLTAITVDVWTLHAELH 232

  Fly   256 GGLY--EFLSEAKRRTSTGQPSRRSTQGLAPSKRSYDNDNYEKLAPIIPKNF-------NFSIKA 311
            .||:  :.|.:.....|...|....|:.|              :.|.:|..|       ...:|.
Human   233 EGLFQSQLLCQGPSLASKPVPCSEVTENL--------------VEPTLPGLFLLQQLPDQVKVKM 283

  Fly   312 ATFSAV-KENSQN---DFSAKLQSFQISGKFNSKVTDEKTL-LPSMLAKLGFHHLDIDTKYEKLL 371
            ...|.| ..|||.   .::.||..|...       .||..| |.|..|......:..:...|..|
Human   284 ENTSVVLSMNSQKRHLTWTLKLLQFLYH-------RDEDQLPLRSFTANSDMAQMSTELLLEDGL 341

  Fly   372 FVEQ-----------------FTIDSVLEKDIFNLYVKLKTFQIIYNHSEIYDFVNNNFLARQRS 419
            .:.|                 .|||       .:..:.|.|..|.|.|.|...::  :.||.:..
Human   342 LLSQSRQRIVCLNSLKASVQVTTID-------LSASLVLNTCIIHYRHQEFSHWL--HLLALETQ 397

  Fly   420 SEAQPMQLIHKQKSLPDHLDLDTAVQSNLRANQRREGGVLEWIMQRIVVKGCAELFNVSLLMKLE 484
            ..:.|:....|:::.|.                         |:..|:..  ..:.||::.::|.
Human   398 GSSSPVLKQRKKRTFPQ-------------------------ILAPIIFS--TSISNVNISIQLG 435

  Fly   485 D--------EHIAMSVSHTRFLLEQIEEKRSNLYENKFLNL------------------LLNQRQ 523
            |        ..|::...|.|         ..::::...|.:                  ..|...
Human   436 DTPPFALGFNSISLDYQHLR---------PQSIHQRGVLTVDHLCWRVGSDSHIQRAPHPPNMHV 491

  Fly   524 WSMELMVETLWSNLGNSINDTNNLKKTHSPGSPFFLGVSLVKLCSYANTTKLDISVHTFRTEYSM 588
            |...|::::.  .|..|.|....|..|.|                  :|..||.::...:.|.|.
Human   492 WGEALVLDSF--TLQGSYNQPLGLSSTQS------------------DTLFLDCTIRGLQVEASD 536

  Fly   589 QLAEFVVKSMECLRQYRGIK-PKNMSGQSHARPNAGLTLSVQPSQSSTSLRVSVKVKDITAYFVN 652
            ..|       :||.:...:. |:  ||:|....::....||     |...:|.:||:|:..:.::
Human   537 TCA-------QCLSRILSLMGPQ--SGKSAVSRHSSFGESV-----SLLWKVDLKVEDMNLFTLS 587

  Fly   653 HHNVYSLLSFSELNLSR-----SQSLTTLKLEEFQMAIMRSMT--ASSLC-LTDFSDVFATCKMI 709
                 :|:..||:.|..     |...:|:.::...:|:::|:|  ....| ..|......:..|:
Human   588 -----ALVGASEVRLDTLTILGSAETSTVGIQGLVLALVKSVTEKMQPCCKAPDIPTPVLSLSML 647

  Fly   710 RLEHEQVEGTMGKLSIYIPGNMEATWNSNLHMHLLTLV------RDM------QDLKTELAIPAS 762
            .:.:   ..::..|.:.....:...|:...||:|...|      ||:      .:....||:..|
Human   648 SITY---HSSIRSLEVQCGAGLTLLWSPPDHMYLYQHVLATLQCRDLLRATVFPETVPSLALETS 709

  Fly   763 SVKKTTPKEG-------------FIVELSAERSTIF--EIKFSDRHSIQIFVESLFFSQKERCI- 811
            ..  |:..||             ..:|:|..:.|.|  |.||     |.:..||:..|:....:
Human   710 GT--TSELEGRAPEPLPPKRLLNLTLEVSTAKLTAFVAEDKF-----ITLAAESVSLSRHGGSLQ 767

  Fly   812 IYAENVFVKIDDQHIFTVKELDLQSVPRLEVLTQERQNFPGFQLPSNKVWVTTIGSFKAIFPYDH 876
            .|...:....|...||..||:::|.:|.||.:...|..||..|...|:||:.:.||....|||.:
Human   768 AYCPELAAGFDGNSIFNFKEVEVQLLPELEEMILHRNPFPALQTLRNRVWLLSFGSVSVEFPYQY 832

  Fly   877 DFYNAVNGECTSHFKWLKMVHNYKK---KPFTVDSPLPCDLVIKIKEFLLEISDDPFEVKLRDNY 938
            ||...:: |.....||||.:|...:   .|..|  |||.||::|::.|.....||.|||||.|||
Human   833 DFSRTLD-EAVGVQKWLKGLHQGTRAWASPSPV--PLPPDLLLKVEHFSWVFLDDVFEVKLHDNY 894

  Fly   939 VLLVDEYLESLKRKALFDKKIGELCSER-LLLPSGTIEGLYANLVKKNSEIYIQRSKKIRESGPV 1002
            .|:.||..||.||..|.|.|:..|..:. .|||:..||.|||:|.:||.|||||||:::..:.|:
Human   895 ELMKDESKESAKRLQLLDAKVAALRKQHGELLPARKIEELYASLERKNIEIYIQRSRRLYGNTPM 959

  Fly  1003 RTRLLAWIMTDVNIMAMADTSIHGYNNVTRIMREIDHESPWPEEGLEFSTLWCRGVNISCTEWKF 1067
            |..||.|.:..:.::|:||.|.||..:|...::|:|..||:|.|||:....|||.:..:...:..
Human   960 RRALLTWSLAGLELVALADASFHGPEHVVEQVQELDPGSPFPPEGLDLVIQWCRMLKCNVKSFLV 1024

  Fly  1068 MLRDFPQPMFCVKSMRLYGNLCGAEQMGSKRAKRDVFIDVGEPFGTDVIQRSMPSLKFYHDFDCE 1132
            .:||:|:.:|.::..||.|.|.|.||.|...::|...:.:|.|:|...::|:||.|||||||..|
Human  1025 RIRDYPRYLFEIRDWRLMGRLVGTEQSGQPCSRRRQILHLGLPWGNVAVERNMPPLKFYHDFHSE 1089

  Fly  1133 LESCSYAFGACWEP---VMAQCNLSFEKISAPSKDPSPPLPFWDKLRLLLHGRLTLIAKQFTILL 1194
            :...:..:|.||:|   ::.||   .:.::.||.|||||||:|||.|||.||...:..:|..:..
Human  1090 IFQYTVVWGPCWDPAWTLIGQC---VDLLTKPSADPSPPLPWWDKSRLLFHGDWHMDIEQANLHQ 1151

  Fly  1195 HASLDPYNTTEEMELTWNNCGIVLTNAKIMFKGELNVTVRTASRYDDCRLLHFPNLKLTIKLKWV 1259
            .|:.|||||||.|...|::........:.:|||:|::.|||||:||||..||.|:|.:|:.|:|:
Human  1152 LATEDPYNTTENMHWEWSHLSFHWKPGQFVFKGDLDINVRTASKYDDCCFLHLPDLCMTLDLQWL 1216

  Fly  1260 CLANPNDHHAVMPCAPDKLPEYSSNQVHDSFRAFRSLNLNIWISFETKPKAGEDLEVDIPSLVLY 1324
            |..||:|||:|...||:.|||....|:|||:|||||.|||:.|..:....:|   .:..|.::||
Human  1217 CHGNPHDHHSVTLRAPEFLPEVPLGQLHDSYRAFRSENLNLSIKMDLTRHSG---TISQPRILLY 1278

  Fly  1325 GSTLRWFESLQLILSGVTRPTRRGPVFNNVRPRKKPLSRHYKKANLQMCLHKFQVLYWMSHALQK 1389
            .|||||.::.....:.||||..||.:|||::|.||.|.:|||:.:......:.||.||.|.|.|:
Human  1279 SSTLRWMQNFWATWTSVTRPICRGKLFNNLKPSKKKLGQHYKQLSYTALFPQLQVHYWASFAQQR 1343

  Fly  1390 GFQLNGRRVSFSSEHSLT-----LNPIDDGLIHRPRADWSTIYMNCELNDAEIWLKSILTEKMDS 1449
            |.|     :..|..|..|     |.|....::.|..:|||...|..:|:...:.|.:..||
Human  1344 GIQ-----IECSQGHVFTRGTQRLIPQAGTVMRRLISDWSVTQMVSDLSQVTVHLMASPTE---- 1399

  Fly  1450 SSENLASAADAFKIVRFYFLSVAKVSYGREALIPTTATSTEEDVKAQSTTP---THKLVVYDLKG 1511
              ||.....|.. :.:.:.||::.::|.|.     :..:.||::.|:...|   ||:|.:.||:.
Human  1400 --ENADHCLDPL-VTKTHLLSLSSLTYQRH-----SNRTAEEELSARDGDPTFHTHQLHLVDLRI 1456

  Fly  1512 AWTKSNRDVAFALFDSFMKSQKLKNNLSTEAVKSYRKEGPNSAVLKHKRSDSTITLSSTNNEVLP 1576
            :||.:|||:||.|:|.:.|:..||.||||||:|.. |..|.....|.||...|...:...
Human  1457 SWTTTNRDIAFGLYDGYKKAAVLKRNLSTEALKGL-KIDPQMPAKKPKRGVPTSASAPPR----- 1515

  Fly  1577 ISNPNASMKKAPAQIHATAMLQQLIAEADHKFNVYSDDHSTQSRELQLQGLQACSAQDIIHENWS 1641
            ::.|:.|.:..........|||:||.|.| :|.|::::.|..|.  ||.|:.||...||.:.|..
Human  1516 VNTPSFSGQPDKGSSGGAYMLQKLIEETD-RFVVFTEEESGMSD--QLCGIAACQTDDIYNRNCL 1577

  Fly  1642 ISLVNSQVLLKGCETSGYVIISAAKAEILQREHRPVWRERSLISKTTWKGLLECMQYYATVSAGD 1706
            |.|||.|::|:|.||.|.||:|||||::||.:|.|.|...:|..||:|..||:.|||:||..:..
Human  1578 IELVNCQMVLRGAETEGCVIVSAAKAQLLQCQHHPAWYGDTLKQKTSWTCLLDGMQYFATTESSP 1642

  Fly  1707 NNSLLEKEIMWLTVDNIQDKDETVINNLPDISHLVGSGRSVGGVVSETVGAFLSDNSGGAQPVQL 1771
            ...  :...:||.|.||::..:   .:|..:..|:.||::|||:|:.|..  .:..:...|..|:
Human  1643 TEQ--DGRQLWLEVKNIEEHRQ---RSLDSVQELMESGQAVGGMVTTTTD--WNQPAEAQQAQQV 1700

  Fly  1772 QRIVSKCKCEFFYVSYGDAIDPNSITEVPPP---PSEELQSPWEKQDDPVDAFTLMHHDLDVCTN 1833
            |||:|:|.|..:|:||...|||...|::.||   .::|.:...:||:..||.|||:||:|::.||
Human  1701 QRIISRCNCRMYYISYSHDIDPELATQIKPPEVLENQEKEDLLKKQEGAVDTFTLIHHELEISTN 1765

  Fly  1834 SLQYAMILDIVNNLLLYVEPQRKQAAEKLTRMRFQLQLHST-EDQKRPIQQKQTVIRSLLMKIRS 1897
            ..||||||||||||||:|||:||:.:||..|:||||::.|. |:|:..|...|..:|..:.:||.
Human  1766 PAQYAMILDIVNNLLLHVEPKRKEHSEKKQRVRFQLEISSNPEEQRSSILHLQEAVRQHVAQIRQ 1830

  Fly  1898 LEKDTHMISKERIEDGDS---LELRQEYDHVQQMIRESKEELNTFSEDLDMMLLCYKETQLSQLS 1959
            |||..:.|.|...:|..:   |:|.|:   :|..:.:.|..|...||:|::::.|:|:.||.:.:
Human  1831 LEKQMYSIMKSLQDDSKNENLLDLNQK---LQLQLNQEKANLQLESEELNILIRCFKDFQLQRAN 1892

  Fly  1960 KISNVRSDESVTMVRTNEICFKRAQWRLTETDGQIGIADLVLSAFLYTKKSKSDDSVEHLLELGN 2024
            |:...:..|.|::||..|..|.:|:|||||.|||:|||:|.|..|||:|.:||||:.|||||||.
Human  1893 KMELRKQQEDVSVVRRTEFYFAQARWRLTEEDGQLGIAELELQRFLYSKVNKSDDTAEHLLELGW 1957

  Fly  2025 IRMENLLPREIYRDVLLATEIQKDMPVDT----HKRVLRIFCREKAPVGGISVKEHFEINVAPIT 2085
            ..|.||||..:|:.||        .|..:    .:..||:|.:.:.||||||||||||:||.|:|
Human  1958 FTMNNLLPNAVYKVVL--------RPQSSCQSGRQLALRLFSKVRPPVGGISVKEHFEVNVVPLT 2014

  Fly  2086 IAITKKFYSTMLKFCFPDRDASETEVSDELDDNASTSSASTTNL------------------QAK 2132
            |.:|.:|:..|:.|.||.|...:.||.||.|    .|...||.:                  ..|
Human  2015 IQLTHQFFHRMMGFFFPGRSVEDDEVGDEED----KSKLVTTGIPVVKPRQLIATDDAVPLGPGK 2075

  Fly  2133 SSTSSSTKRSGKGKKGAKDSEFYVKIEKDDVEKMKERAEKNKLFIYIKIPEVPVRVSYKGNKEKN 2197
            ......|:.||..:...|..|..|    ||::||||||..|..|||||||:||:.|||||  |||
Human  2076 GVAQGLTRSSGVRRSFRKSPEHPV----DDIDKMKERAAMNNSFIYIKIPQVPLCVSYKG--EKN 2134

  Fly  2198 LEDITDYSLVIPTLEYHNVTWTWLDLLLAMKSVSRRVIFSQAIKQKLHIHQRQPILSAGERAT-- 2260
            ..|..|.:||:|.|||||.||||||..:|:|..||:.:.:|.||:||.:.........|:..|
Human  2135 SVDWGDLNLVLPCLEYHNNTWTWLDFAMAVKRDSRKALVAQVIKEKLRLKSATGSEVRGKLETKS 2199

  Fly  2261 -----PQEAEDKAVMLFGNRLLNENRNQKKGVFKFASSGKR 2296
                 .||.|:||.:|.|..:.::|.. ||.:|     |:|
Human  2200 DLNMQQQEEEEKARLLIGLSVGDKNPG-KKSIF-----GRR 2234

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hob	NP_001303402.1	Fmp27	26..666	CDD:287333	124/702 (18%)
		DUF2405	<887..959	CDD:287288	33/74 (45%)
		Fmp27_GFWDK	1071..1203	CDD:287336	54/134 (40%)
		Apt1	1774..2239	CDD:287340	212/493 (43%)
KIAA0100	NP_055495.2	Fmp27	26..674	CDD:287333	136/790 (17%)
		Fmp27_GFWDK	1028..1160	CDD:287336	54/134 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1495..1529		7/38 (18%)
		Apt1	1703..2176	CDD:287340	212/493 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2074..2099		6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158269
Domainoid	1	1.000	375	1.000	Domainoid score	I880
eggNOG	1	0.900	-	-		E1_KOG1910
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H34730
Inparanoid	1	1.050	1063	1.000	Inparanoid score	I252
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46407
OrthoDB	1	1.010	-	-		D26089at2759
OrthoFinder	1	1.000	-	-		FOG0003609
OrthoInspector	1	1.000	-	-		oto90002
orthoMCL	1	0.900	-	-		OOG6_106761
Panther	1	1.100	-	-	LDO	PTHR15678
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1822
SonicParanoid	1	1.000	-	-		X2484
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	15	14.840