DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment hob and YPR117W

DIOPT Version :9

Sequence 1:NP_001303402.1 Gene:hob / 38395 FlyBaseID:FBgn0035420 Length:2300 Species:Drosophila melanogaster
Sequence 2:NP_015442.1 Gene:YPR117W / 856233 SGDID:S000006321 Length:2489 Species:Saccharomyces cerevisiae


Alignment Length:2804 Identity:517/2804 - (18%)
Similarity:961/2804 - (34%) Gaps:879/2804 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 QLLLFCLALFIFVYWVLPTGISWYLVKRFRVKVRIGRISLPYL---SLKNVHISKSGFSVQIEEV 65
            :|||..:...|.:..:....:||.|:.|...   |.:||..|.   |::...|......:.|.::
Yeast    14 KLLLGFMLFIISIQKIASILMSWILMLRHST---IRKISFGYFFGTSIRRAFILTDFAQIYIGKI 75

  Fly    66 CLRSSF-----FTTEVTKLLSIYIRDIRINKDIHSRQDDSYDQDSYELRRTQTLAGKASEAKGVP 125
            .||..:     |.....||         ..||.|.....:.|..:|...|.||            
Yeast    76 TLRIGWKPGIVFHNVDLKL---------FGKDSHITAHSTKDSRTYFNPRDQT------------ 119

  Fly   126 DFRQTKVPASIITFAQFMAVHVNNISVVLMNNDFDPGWFIHATAKELHLDGSIVQNARVLLVNAA 190
                       .||.      :|...:.::...|....|.|..|       ..|.|.:...:|  
Yeast   120 -----------FTFV------INRRVLSILKLVFSFSTFFHTLA-------LTVPNGKQYKLN-- 158

  Fly   191 LSEAQAKMLRHCSSRRQSLENLNKIRPCLGEVSF----DMTLDASLFAQG---PLSMDTLSLVIN 248
                                        :|.::.    |.|:....|...   |.:.|||:    
Yeast   159 ----------------------------IGSITISHPHDDTIKLEAFLHDFTHPETKDTLN---- 191

  Fly   249 NAKSVIHGGLYEFLSEAKRRTSTGQPSRRSTQGLAPSKRSYDNDNYEKLAPIIPKNFNFSIKAA- 312
                  |.|.:......|                       ::|.......:|.||:..|:|.: 
Yeast   192 ------HTGFFMVCKIGK-----------------------EDDTGSNCTKVILKNWKSSLKISD 227

  Fly   313 -TFSAVKENSQNDFSAKLQSFQISGKFNSKVTDEKTLLPSMLAKLGFHH-------LDIDTKYEK 369
             .:...::..:|..|..::.|..........:..|.|.|       ||:       ||:..:..|
Yeast   228 VCWHLPEKKGKNLHSEPVEPFSAGDDAEMLTSYRKMLKP-------FHYPLKTLNILDLKVENVK 285

  Fly   370 LLFVEQFTIDSVLEKDIFNLYVKLKTFQIIYNHSEIYDFVNNNFLARQRSSEAQPM--------Q 426
            |::.::|||      .|.:..:.|::..|:.|.|.:               |..|:        :
Yeast   286 LIYKKKFTI------RISSAQLYLESISILNNVSAL---------------ELLPLNKPTWGDFE 329

  Fly   427 LIHKQKSLPDHLDLDTAVQSNLRANQRREGGVLEWI-----MQRIVVKGCAELFNVSLLMKLEDE 486
            |.....::...:|.:|||:... .|......:|.::     ::|..|.....:.|.|:.:.:   
Yeast   330 LSLSANAVVVDIDGNTAVRIPF-GNVILTSDILLFLLDNVPLRRTKVSSILNIINPSVFLTI--- 390

  Fly   487 HIAMSVSHTRFLLEQIEEKRSNLYEN---KFLNLL---LNQ-RQWSMELMVETLWSNL------- 537
            |..:.|.|   |:::.:...::...|   :.||:|   ::: ..::.||::....|.|       
Yeast   391 HQVLEVLH---LVDKFDSPETSSCTNTNDRSLNILDLDIDRLPSFNFELLMSNFISRLHISDEEN 452

  Fly   538 -------GNSINDTNNLKKTHSPGS--------PF---------------FLGVSLVKLCSY--- 569
                   .:::...|||..|...|.        ||               .:|.||    ||   
Yeast   453 VTFKVFSTHALFSRNNLSMTPKKGQVMQIRPDWPFAKTALVSDQLSNYIKIVGTSL----SYLRI 513

  Fly   570 -----ANTTKLDI----SVHTFRTEYSMQLAEFVVKS-----------MECL--------RQYRG 606
                 ||...:.:    .:.||..|:|.  ::.:|:|           :|.|        :.|..
Yeast   514 PTEQDANPVSIPVCGFERLDTFLDEFSN--SKLIVQSTLRHSYVSLENIEVLHTLSRAFDKIYLL 576

  Fly   607 IKPKNMSGQSHARPNAGLTLSVQPSQSSTSLRVSVKVKDITAYFVNHHNVYSLLSFSELNLSRSQ 671
            |..:.....:| :.|.|....:..::.:.:..:.:::|||:.         |||....|    .:
Yeast   577 ISSRTKRNAAH-KANGGKLGDLNEAKKTFNWSLKLRMKDISC---------SLLVAGFL----PK 627

  Fly   672 SLTTLKLEEFQMAIM----RSMTASSLCLTD-----FSDVFATCKMIRLEHEQVEGTMGKLS--- 724
            :|..::.|.|.::.:    :.:...|:.|.|     |:.:.|:.      :..::||..|.|   
Yeast   628 NLDPVEAENFNLSDVTRGAKVVFTESILLADSQEKNFTIIDASV------YRFMDGTTYKPSPEV 686

  Fly   725 IYIPGNMEATWNSNLHMHLLTLVRDMQDLKTELAI-------------------------PASSV 764
            |....|:..::|.:..:|.     .:..:|.::.:                         ..|||
Yeast   687 IIQFTNLLLSFNDSDEIHF-----SLPKIKFKMDVNIIWLWFYIRSIWIKFRPNSKLSRNSVSSV 746

  Fly   765 KKTTPKEGFIVELSAERSTIFEIKFSDRHSIQIFVESLFFSQKERCI------IYAENVFVKIDD 823
            |.....:...|::.   ..|.|:.......:.:..|.:..|...:.:      .|..:|:||   
Yeast   747 KSVNVLDRLRVDIG---KMIIELTLPHNTEVLLIFERIGLSSSTKNLTIASLSAYVVSVYVK--- 805

  Fly   824 QHIFTVKELDLQSVPRLEVLTQERQNFPGFQLPSNKVWVTTIGSFKAIFPYDHDFYNAVNGECTS 888
             ||...  :.|.::...|:.|:|      .....:.|..|::..|.|  .|...||...:...|.
Yeast   806 -HIKVY--VSLLNINDFELDTEE------LICKKSAVINTSLIHFHA--EYHFRFYMITDNIVTL 859

  Fly   889 H--FKWLKMVHN--------YKKKPFTVDSPLPCDLVIKIKEFLLEISDDPFEVKLRDNYVLLVD 943
            :  ||.:|:..:        |.::.|....|   :|.|..::||::|.:||||.:|  ..:|.|.
Yeast   860 YKSFKQIKLAFSNLNEFKRLYPQQQFPKKVP---NLHICCQDFLIDIEEDPFEQEL--GLILKVG 919

  Fly   944 --EYLESLKRKALFDKKIG--ELCSERLLLPSGTIEG------LYAN-----------LVKKNSE 987
              |..|.||:...|.:|:.  |..:.||.....|..|      .|||           |::..|.
Yeast   920 VLEQRERLKKLEEFKEKLSTYEDMNVRLRSLYDTSRGQSFFPEFYANDQEYEQKAYLRLLENFST 984

  Fly   988 IYIQRSKKIRES---GPVRTRLLAWIMTDVNIMAMADTSIHGYNNVTRIMREIDHESPWPE---- 1045
            .:|.|.:|.:.|   .|.|......:.|..::.....||    .....:::::|.:...|.    
Yeast   985 SWIARYRKAKLSFYGMPYRVISREELGTKYHLFTRQKTS----TVANLVVKDLDFKLGSPSFPLD 1045

  Fly  1046 --------------EGLEFSTLWCRGVNISCTEWKFMLRDFPQPMFCVKSMRLYGNLCGAEQMGS 1096
                          :..|::.|...|:.|....|:..|||:|.|..........|::..||:|.:
Yeast  1046 NYMDFVYQYGKKVPKSTEYTLLIILGLKIKSALWELRLRDYPIPAISFPDTFTTGDVVFAEKMPA 1110

  Fly  1097 ------------KRAKRDVFIDVGEPFGTDVIQRSMPSLKFYHDFDCELESCSYA---FGACWEP 1146
                        ..|:|..:.|....:|..:| |::.|:|.|.:....:.|.|.|   :|...:|
Yeast  1111 PCALHTVYVPFVSSAQRSPYNDANTIYGLHII-RTINSVKTYFNIRSMVTSSSSARITWGKSLQP 1174

  Fly  1147 VMAQCNLSFEKISAPSKDPSPPLPFWDKLRLLLHGR-LTLIAKQFTILLH--ASLDPYNTTEE-- 1206
            ......|.|:.::.|..|||..|.||||.|.|:||: :...:::..|.|:  .|.|||..|::  
Yeast  1175 GYESLMLWFDFLTKPLIDPSKKLGFWDKFRYLVHGKWIYEFSEESEIHLNIKGSHDPYKITDDGA 1239

  Fly  1207 -MELTWNNCGIVL-----TNAKIMFKGELNVTVRTASRY-----DDCRLLHFPN--LKLTIKLKW 1258
             :...|:. |..:     |:.|...|.|       :.|:     |..::..|..  :||..::.|
Yeast  1240 GLAFCWSG-GTTIYVHNSTDPKEFLKIE-------SQRFQLAVPDFAKVSKFDKVFMKLDGRVIW 1296

  Fly  1259 VC--------LANPND---------HHAVMPCAPDKLPEYSSNQVHDSFRAFRSLNLNIWISFET 1306
            ..        ::...|         |:.:....||.:.:...   ||:::.||:..::  :||..
Yeast  1297 TLGLLFEQGDISKAGDEERFLPNRPHYEIQLMNPDGVADLDH---HDTYKGFRTSFIH--MSFGV 1356

  Fly  1307 KPKAGEDLEVDIPSLVLYGST--LRWFESLQLILSGVTRPTRRGPVFNNVRPRKKPLSRHYKKAN 1369
              .:.|...::...|..|..|  .:|:.......||   |.|:|.:|.:|...|....|......
Yeast  1357 --YSSEHGSINSLYLAPYALTHFFKWWNLFHTYTSG---PIRQGRLFTDVLQNKTKFGRSLFTIA 1416

  Fly  1370 LQMCLHKFQVLYWMSHALQKGFQLNGRRVSFSSEHSLTLNPIDDGL---IHRPRADWSTIYMNCE 1431
            .|:.|.:..|.:...|...:......|:::|:.     |....|.|   :|:.|.  ...:.|.:
Yeast  1417 YQLHLKRLMVTHIYRHITTQYDLEKDRKITFTG-----LKGRFDSLKIDLHQKRV--KLTHTNQK 1474

  Fly  1432 LNDAE-IW---------------------------LKSILTEKMDSSSENLAS------------ 1456
            ||.:: :|                           :|.|||..:|...|:..|            
Yeast  1475 LNKSKPVWKFKMSRGEIDCAEADIRILSTLFDQEAVKEILTSGLDGILEDEPSRPITPQDVEYLR 1539

  Fly  1457 -------------------AADAFKIVRFYFLSVAKVSYGR------------------------ 1478
                               ::...|:.....|...::||.|                        
Yeast  1540 ESDWYDYEDYIDLNQVPLGSSLPLKLEAIPLLYSPRISYFRKINDDGYVLAYPFGTEESHNCLIG 1604

  Fly  1479 --------EALIPTTATSTEEDVKAQSTTPTHKLVVYDLKGAWTKSNRDVAFALFDSFMKSQ--K 1533
                    |.|........||.:|....|.:.   :...||..:.|.....:|   ..:|::  :
Yeast  1605 KNHPELTQEKLATERKREIEEQLKLLHITLSE---LQSNKGGGSVSGNSERYA---RELKAEVAE 1663

  Fly  1534 LKNNLST-----------EAVKSYRKEGPNSAVLKHKRSDSTITLSSTNNEVLPISN-------- 1579
            |.:.|.|           |.:.....:|.:|:.|    ||:.:.|.:..    ||.|        
Yeast  1664 LNHRLHTVNTILSDLKISETIPGGNTDGDSSSSL----SDTDVNLENAP----PIQNRISLLRTN 1720

  Fly  1580 ---PNASMKKAPA-QIHAT----AMLQQLIAEADHKFNVYSDDHSTQSRELQ------------- 1623
               ...||:||.. |:.:|    .|:..:..:.|:|...:..::::.:.|.:             
Yeast  1721 TVESFVSMRKASTMQVESTYDNRFMVHNIELKIDNKIRHHLLEYASSAFERKSMRFAVTYKSVTI 1785

  Fly  1624 --------LQGLQ--------------ACSAQDIIH----------------ENWSISLVNSQVL 1650
                    |.|::              |.:::.|.|                :|:...|::.||.
Yeast  1786 LKELLGNVLTGVRTSVEDYGSILEDDLASNSEFIEHFEKLIREVPSDDFDYVDNYLFRLISPQVQ 1850

  Fly  1651 LKG-CETSGYVIISAAKAEILQREHRPVWRERSLISKTTWKGLLECMQYYATVSAGDNNSLLEKE 1714
            :|. .|.:..||::|...|:                     |:::.:|.|     |.:...:.  
Yeast  1851 IKSDVERNAAVILAARDIEM---------------------GIIDIVQVY-----GKSGKRIP-- 1887

  Fly  1715 IMWLTVDNIQDKDETVINNLPDISHLVGSGRSVGGVVSETVGAFLSDNSGGAQ----------PV 1769
               :.||.|.:...:.::.  ||.......:.:.|    ..|.|...|..|:.          |:
Yeast  1888 ---VDVDTIVETRYSAVSK--DIQLFTLFKKDLEG----PEGRFFHKNGYGSDKESDIWPPWIPL 1943

  Fly  1770 QL--------QRIVSKCKCEFFYVSYGDAIDPNSITEVPPPP---SEELQSPWEKQDDPVDAFTL 1823
            ::        :.:..|.:..|             :|.|.|.|   |....|.:...    ..|.:
Yeast  1944 EMCFDGSLLDKHVFLKRRSMF-------------LTYVAPNPLFFSANDTSAFSYD----SRFRI 1991

  Fly  1824 MHHDLDVCTNSLQYAMILDIVNNLLLYVEPQRKQAAEKLTRMRFQLQLHSTEDQKRPIQQKQTVI 1888
            ....|.:.::..||..:..|..:||.: .....:..|||:|:.|      |::.:..::.....:
Yeast  1992 AFPGLVLTSDCQQYCAVYAIAEDLLSF-GSSLDEKVEKLSRILF------TDEVRNNLENLDVSV 2049

  Fly  1889 RSLLMKIRSLEKDTHMISKERIEDGDSLELRQEY--DHVQQMIRESKEELNTFSEDLDMMLLCYK 1951
            .:.|              :|||::   |...:.|  .|..::..:|.:|| ||    |:.....|
Yeast  2050 VTAL--------------QERIKE---LYYTRAYLKLHEPRLFMKSGQEL-TF----DIQTSTLK 2092

  Fly  1952 ETQLSQLSKISNVRSDESVTMVRTNEICFKRAQWRLTETDGQIGIADLV---------------L 2001
            .|.|....|.:..|      |...|.:..||.:|       |:|..:|:               |
Yeast  2093 LTLLMTAIKKTYDR------MGSGNRVIQKRLRW-------QVGTDELIWELYDESKTPFVTIGL 2144

  Fly  2002 SAFLYTKKSKSDDSVEHLLELGNIRMENLLPREIYRDVLLA----TEIQKDMPVDTHKRVLRIFC 2062
            ....:.:...||.:..:.:.:.:::..|.....:|.::|..    :...|:.|      ::.||.
Yeast  2145 GPSTFIRSETSDGTNSNKVSISSLQCFNQQENPVYTELLAPFYENSSYNKNAP------MVEIFW 2203

  Fly  2063 REKAPVGGISVKEHFEINVAPITIAITKKFYSTMLKFCFPDRDASETEV-SDELDDNASTSSAST 2126
            .....|||||..:...:::.|:...:..|....::.:.||..:.:..|. |.||...:||||..:
Yeast  2204 ILGPSVGGISDLQDLIVSLQPLIFKMDHKTSEKLMNYLFPKIEQTSIEPNSPELVPRSSTSSFFS 2268

  Fly  2127 TNLQAKSSTSSST-------------KRSGKGKKGAKDSEFYVKIEKDDVEKM------------ 2166
            ::...:.|.|:.:             .||.:.|:|       :|..|.|..|:            
Yeast  2269 SSPVLRHSLSNGSLSVYDAKDVDSWDLRSIQSKEG-------IKKHKGDHRKLSASLFVQPDYNI 2326

  Fly  2167 KERAEKNKLFIYIK---IPEVPVRVSYKGNKEKNLEDITDYSLVIPTLEYHNVTWTWLDLLLAMK 2228
            .|..:::..|..:|   |.:..:.|.|||: ...|.|:.:..:.:|.|:|||..|:..:...|:|
Yeast  2327 NEMVKRSGTFFNVKSIIIRKTLMSVCYKGS-HSLLTDVNNLIVRVPVLKYHNKLWSREEFFTALK 2390

  Fly  2229 SVSRRVIFSQAIKQKLHIHQRQPILSAGERATPQEAED-KAVMLFGNRLL---NENRN-----QK 2284
            ....|::..       |:..     ..|.:..|.:.|: |...:..:|||   ::||:     :.
Yeast  2391 RDVVRIVLQ-------HLGN-----IIGNKFLPHKKENKKKTSMEIHRLLSPDSQNRDNSHILEV 2443

  Fly  2285 KGVFKFASS 2293
            :|...|.||
Yeast  2444 EGHNSFYSS 2452

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hobNP_001303402.1 Fmp27 26..666 CDD:287333 128/751 (17%)
DUF2405 <887..959 CDD:287288 24/83 (29%)
Fmp27_GFWDK 1071..1203 CDD:287336 42/149 (28%)
Apt1 1774..2239 CDD:287340 103/517 (20%)
YPR117WNP_015442.1 DUF2405 792..944 CDD:402076 43/170 (25%)
Fmp27_SW 974..1065 CDD:402084 14/94 (15%)
Fmp27_GFWDK 1085..1234 CDD:402113 42/149 (28%)
Fmp27_WPPW 1449..1945 CDD:402121 85/553 (15%)
Apt1 1958..2401 CDD:402116 103/522 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C157345851
Domainoid 1 1.000 59 1.000 Domainoid score I2587
eggNOG 1 0.900 - - E1_KOG1910
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 122 1.000 Inparanoid score I1295
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0003609
OrthoInspector 1 1.000 - - otm46799
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR15678
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1822
SonicParanoid 1 1.000 - - X2484
TreeFam 00.000 Not matched by this tool.
1010.010

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