DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment hob and FMP27

DIOPT Version :9

Sequence 1:NP_001303402.1 Gene:hob / 38395 FlyBaseID:FBgn0035420 Length:2300 Species:Drosophila melanogaster
Sequence 2:NP_013559.1 Gene:FMP27 / 851175 SGDID:S000004446 Length:2628 Species:Saccharomyces cerevisiae


Alignment Length:2949 Identity:538/2949 - (18%)
Similarity:952/2949 - (32%) Gaps:1051/2949 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 LLFCLALFIFVYWVLPTGISWYLVKRFRVKVRIGRISLPYLSLKNVHISKSGFSVQIEEVCLRSS 70
            ::|.:.:.::.:.:......|..  :..::..:| |::.:::|..:.|  .|.|::...|.|:|.
Yeast     1 MMFPINVLLYKWLIFAVTFLWSC--KILLRKLLG-INITWINLFKLEI--CGLSLEDGTVRLKSV 60

  Fly    71 FFTTEVTKLLSIYIRDIRINKDIHSRQDDSYDQDSYELRRT--QTLAGKASEAKGVPDFRQTKVP 133
            .|.....||   :|:.:||:.. .|..:|.:.:...|..||  :|           |:.......
Yeast    61 RFAVFERKL---FIKGLRIDSK-KSSTNDLHKELPREEERTFIET-----------PEDNGGGFI 110

  Fly   134 ASIITFAQFMAVHVNNISVV-----LMNNDFDP---GWFIHAT----AKELHLDG---SIVQNAR 183
            :.|::.:|:.   :|.::::     |:|||...   |:|:...    .|.|..|.   .::.|.:
Yeast   111 SKILSLSQYW---LNGVTIILEDTQLVNNDITIEKFGFFLSIDNSKHIKSLRFDSFLRKLLWNGQ 172

  Fly   184 VLLVNAALSEAQAKMLRHCSSRRQSLENLNKIRPCLGEV------SFDMTLDASLFAQGPLS--M 240
            .::.:|..                 :.|.|.:   :||:      ...:.||..|   |.|:  |
Yeast   173 TIIADAIF-----------------IVNTNLL---IGEIMNPLKDGLQVGLDLKL---GDLNIPM 214

  Fly   241 DTLSLVIN--NAKSVIHGGLYEFLSE-------------AKRRTSTGQPSRRSTQGLAPSK---- 286
            :.|:|.||  |...:.:..|.:.|::             ||.:........:....:.|.|    
Yeast   215 NLLNLFINKENVDLMSNEKLLQRLADTTKANEELKDEDIAKMKDDLVYAMEKFVDRIKPLKEMNV 279

  Fly   287 -------RSYDNDNYEKLA--------PIIPKNFNFS-------IKAATFSAVKENSQNDFSAKL 329
                   :.:...|:.:|.        .::..|.||:       :...|....:.:|...||..:
Yeast   280 TVDKLQIKDFPLTNHPELLGMNKYISYNVLVSNINFNTNRFRNEMPGYTLIFEERDSPFKFSIIM 344

  Fly   330 QSFQISGKFNSK-VTDEKTL----LPSMLAKLGFHHLDIDTKYEKLLFVEQFTIDS-----VLEK 384
            ..|.|....|.| .:..|.|    :|           ::....|..||.::|.:.:     .||.
Yeast   345 ARFNIYLNLNRKHQSHAKQLKIIEIP-----------NVSIFGETNLFSQKFRLSNNLHAKELEN 398

  Fly   385 DIFNLYVKLKTFQIIYNHSEIYDFVNNNFLARQRSSEAQPMQLIHKQKSLPDHLDLDTAVQSNLR 449
            .|||:...:.:..|      ..|.||.:|:                 |....::.:.|   |:..
Yeast   399 AIFNIKGNISSLTI------DMDPVNISFI-----------------KCFLSNIKVFT---SSCP 437

  Fly   450 ANQ-RREGGVLEWIMQRIVVKGCAELFNVSLLMK--LEDEHIAMS--------------VSH--T 495
            .|: .:|...::::.:|.|:....:.|...:.||  |:|....::              :||  .
Yeast   438 KNKILKENSHVKFLTRRRVLFDYFKCFLPLINMKFTLDDPKFVINDKDDLIIGKFSVFMISHHSK 502

  Fly   496 RF-----LLEQIEEKRSNLYENKFLNLLLNQRQWSMELMVETLWSNLGNSINDTNNLKKTHSPGS 555
            |:     |:|:.||.:...||:          .|::||:                ::|..|    
Yeast   503 RYTLGNNLMEEKEETQHIFYES----------HWNVELL----------------DMKLQH---- 537

  Fly   556 PFFLGVSLVKLCSYANTTKLDISVHTFRTEYSMQLAEFVVKSMECLRQYRGIKPKNMSGQSHARP 620
                   ::|...|.:|.   :.|.:...|..:||...::.|                      .
Yeast   538 -------IIKHQKYEHTI---LRVDSIAIEEKVQLLPDILCS----------------------A 570

  Fly   621 NAGL-TLSVQPSQSSTSLRVSVKVKDITAYFVNHHNVYSLLSFSELNLSRSQSLTTLKLEEFQMA 684
            ||.: ||.:..|:..|.:.:|..|.::.:...|....|    |.|.....:.:|..:|.|...||
Yeast   571 NADIDTLMLDLSELPTMVMLSELVHNLDSQLANVEENY----FKEFYEKFASNLQNMKAECSNMA 631

  Fly   685 IMRSMTASSLCLTDF-----SDVFATCKMIRLEHEQVEGTMGKLSIYIPGNM------------- 731
              :.:....:..:||     .|.|   ..|::....:..|:|..|:::|.::             
Yeast   632 --KCLRQKEILPSDFMFQQLPDFF---DYIKINIRDISSTLGARSVFMPRDVFSSVDSQSSKDLI 691

  Fly   732 ---------------------EATWNSNLHMHLLTLVR----------------------DMQDL 753
                                 :..|::.:..:..|:||                      |:.|:
Yeast   692 DGKLRKYCNTVEKLQIALFGDKTQWHNKIGSNHATMVRSGQLTNFSKDNKQNPNHKSSIADLDDI 756

  Fly   754 KTELAIPASSVKK--------TTPKEGFIVELSAERSTIFEIKFSDRHSIQIFVESLFFSQKE-- 808
            .|..|...:.:..        ||...|...|:|.|.||....|.|:. ||::|.::..||..|  
Yeast   757 STSDATEVNHLWNINLLVNDITTSIIGETPEVSEELSTKTVSKVSNL-SIKLFPDTESFSSNESD 820

  Fly   809 ------------RCIIYAENVFVKIDDQH----IF------------------------------ 827
                        ..::...::|:.:...|    ||                              
Yeast   821 SKIILQINHSRGTSVVSLMSIFLAVSGIHTLNQIFGHCIHQKMRQSKTKQYFLALSESKKKSCIK 885

  Fly   828 -----------------------------------------TVKELDLQSVP----RLEVLTQER 847
                                                     |||..:..||.    |:.|.:..:
Yeast   886 SIKWGQLKELLEINFSSEYISQIIALPNGLRTKFEPTSTFITVKNCNTISVSGQYFRMMVESPTQ 950

  Fly   848 QNF-------PGF-----------------------QLPS-----NKVWVTTIGSFKAIFPYDHD 877
            .||       .||                       :|||     |..|..:|       |:..:
Yeast   951 PNFWERMICINGFKVMIHIDLLKQQMKKLNSLQNWEKLPSAITLENDSWHFSI-------PHHFE 1008

  Fly   878 FYNAVNGECTSHFKWLK-MVHNYKKK-------PFTVDSPLPCDLV-IKIKEFLLEISDDPFEVK 933
            .:..::...|. ||.:| |:::.|..       |..:::||....: :|.|.:|..|||||.|.:
Yeast  1009 MFKIIDSIPTI-FKSIKQMLYSLKTSKDDLIIFPHKIETPLSLPKIKLKSKRWLFSISDDPLEAE 1072

  Fly   934 LRDNYVLLVDEYLESLKRKALFDKKIGE------------------------------------- 961
            |...:.:.:.|..|.|.:...|:|:|.|                                     
Yeast  1073 LNTIFQIGLQEQRERLAKLQEFNKRISEDLIKSQKNAKEMKDDFEAIDNAILKHRTGLWAKDGKK 1137

  Fly   962 ------LCSERLLLP-------------------SGTIEGLYANLVKKNSEIYIQRSK--KIRES 999
                  ..||..|.|                   |..||..|..|:...|:.:|:|.|  |::|.
Yeast  1138 RLRKSATDSEIPLTPAALNINGKRDDRPDRTQFISPEIENAYNTLLANFSDSWIKRVKEYKVKER 1202

  Fly  1000 G---------------------------PVRTR--LLAWIMTDVNIMAMADTSIHGYNNVTRIMR 1035
            .                           |..|.  |:..|:.:::|..:..:.  |..|:...:.
Yeast  1203 REFDKNFSFLWGFIDYTKLPKDINKKVLPFSTNPFLMNLIIENIDIDIIRPSC--GIENIPNFIH 1265

  Fly  1036 EIDHESPWPEEGLEFSTLWCRGVNISCTEWKFMLRDFPQPMFCVK-----------SMRLYGNLC 1089
            ::....|   :..|:|.:....::...:|.::.|||:|.|...:.           .||:||:..
Yeast  1266 DVGKGVP---KNTEYSIMIPMHLDAKFSEVRWHLRDYPLPFVSIPPLSSTQSKETIPMRIYGDFM 1327

  Fly  1090 GAEQM-GSKRAKRDVFIDV--------GEPFGTDVIQRSMPSLKFYHDFDCELES---CSYAFGA 1142
            ..|.| .|.|..|.:|:.:        .:.:.:..:.|:|.|.|.:.|.:.|:.|   ....:|.
Yeast  1328 ITEDMLQSDRELRTLFVPLIPSVTVENTDRYYSLFVPRTMTSAKIFTDLNFEINSNHTTRVTWGG 1392

  Fly  1143 CWEPVMAQCNLSFEKISAPSKDPSPPLPFWDKLRLLLHGRLTLIAK---QFTILLHASLDPYNTT 1204
            .::|.:.|.....:..|.|..|||..|.||||.|.|.||::.::.|   :|.|.|..:..||   
Yeast  1393 SYQPAIQQTMQCLDNFSKPPLDPSVKLGFWDKTRYLFHGKINIVWKKRGKFEISLKGAKSPY--- 1454

  Fly  1205 EEMELTWNNCGIVLTNAKIMFKGELNVTV---RTASRYDDCRL--LHF--PNLKLTIKLKW---- 1258
               .|...:.|.:     :.|.|.:|:..   ....::..|..  :||  ||......|.|    
Yeast  1455 ---MLGGESAGFI-----VGFDGNVNLKCNEDNDPKKFLSCSADKVHFSIPNYFAKPLLVWSRPS 1511

  Fly  1259 ---VCLANPND------------------------------------------------------ 1266
               :.:.|.:|                                                      
Yeast  1512 TNTMFIPNQDDTNMQRYASFYYLLNTTSSKNEKADKEIMGKSFIEKTGIKLSGGMTLDMGILFER 1576

  Fly  1267 --------------HHAVMPCAPDKLPEYSSNQVHDSFRAFRS--LNLNIWIS---------FET 1306
                          |:....|.|..:.:.|.   |||:..|||  ::::..:|         .:.
Yeast  1577 LGPSLNERTFESKKHYLTRLCNPIYVQDLSK---HDSYAGFRSDFIHMSFGLSSNSNSAYNAMQL 1638

  Fly  1307 KPKAGEDLEVDIPSLVLYGSTLRWFESLQLILSGVTRPTRRGPVF--NNVRPR----KKPLSRH- 1364
            .|..             :.:...|::|    .|| ..|.||||:|  .::.|:    ...:|.| 
Yeast  1639 SPNG-------------FKAFFVWWKS----FSG-NFPVRRGPLFGLQSISPKFGEHLYTISYHA 1685

  Fly  1365 ----------YKKANLQMCLHK--FQVLYW------MSHALQKGFQLNGRRVSFSSEHSLTLN-- 1409
                      |..|:....|.|  .:|..:      .||.:....|    |....:|:...||  
Yeast  1686 DVSPLFINYMYHNADADQILRKNYLEVAEFAGLKAKSSHFIMDLHQ----RKEVLTEYQAGLNVR 1746

  Fly  1410 -------------PIDDGLIHRPRADWSTIYMNCELNDAEI--------WLKSILTEKMDSSSEN 1453
                         ...|..|.....::|.:....|..|||.        ||.  :|:..|:...|
Yeast  1747 RRVMKLKFLAGDVVCQDVDIRTVSGEFSKLNYIEEKEDAEYDIFDNDMSWLD--ITDFQDAFFIN 1809

  Fly  1454 LASAADAFKIVRF----YFLSVAKVSYGREALI-PTTA-------------------TSTEEDVK 1494
            ..:.....||:.|    .|....:.|||.:..: |.|.                   .|...|:.
Yeast  1810 PDNYLPKIKIMPFAFSPQFAYQKRASYGDKYQVDPKTCKPITPFDNRVSHGCTLGHNVSLRTDLV 1874

  Fly  1495 AQSTTPTHK----------------LVVYDLKGAWTKSNRDV--AFALFDSFMKSQK-------- 1533
            .:..|...|                :...:|....:|:|..|  |..|...|.|..|        
Yeast  1875 EKRVTVLKKFREKLQEGIRKNKSAGVSEENLNDLLSKANSSVENAELLLKDFQKIFKQHEAGQTE 1939

  Fly  1534 ----------LKNNLSTEAVKSYR----------KEGPNSAVLKHKRSDSTITLSSTNNEVLPIS 1578
                      |||...|.....:|          .|...||:.|.      ...::.:||...::
Yeast  1940 QPFHFDSLNLLKNTKKTLKQFEHRFFIFNVLLKWNEDARSAIFKF------FYYANLSNEFASLA 1998

  Fly  1579 NPNA------SMKKAPAQIHATAMLQQLIAEADHKFNVYSDDHSTQSRELQLQGL---------- 1627
            :...      .:|:.......|:|  :.|.|...|.|.....||....|...:.|          
Yeast  1999 SGKGLREFEDVIKQREMTDDTTSM--EAIPEGTDKANTTKQCHSCDDTEFTTENLLNIFEKNITQ 2061

  Fly  1628 QACSAQDIIHENWSISLVNSQVLLKGCET-SGYVIISAA------------------KAEILQRE 1673
            .:|..::.||..:.:..:..|:.|...|. ...|::|:.                  ..:|..:.
Yeast  2062 LSCDIKNKIHHKFFVQFITPQIQLTSLENPEACVLVSSPFFMLKTLEFDANTTSNTYMQDIFLKR 2126

  Fly  1674 HRPVWRERS--LISKTTWKGLLECMQYYATVSAGDNNSLLEKEIMW-------LTVDNIQDKDET 1729
            |..::...:  |.:|..::...|.  |:.:.|.|.     :|:..|       |..:....|.:.
Yeast  2127 HGILFGNANAFLFNKKDYQEFFEL--YFGSSSYGQ-----DKKEQWPPWLGLELGFEPSALKKKA 2184

  Fly  1730 VINNLPDISHLVGSGRSVGGVVSETVGAFLSDNSGGAQPVQLQRIVSKCKCEFFYVSYGDAIDPN 1794
            |:.|:..:.|            .:.:..|.:.                      |.|..|.|:.|
Yeast  2185 VVRNISALLH------------HQKLAPFSAK----------------------YDSLKDKIEDN 2215

  Fly  1795 SITEVPPPPSEELQSPWEKQDDPVDAFTLMHHDLDVCTNSLQYAMILDIVNNLLLYVEP---QRK 1856
            ....||                          .::|..||.:|.|:..:...|.|||||   :.|
Yeast  2216 ICGYVP--------------------------QVNVQVNSDEYLMLTKMALKLFLYVEPEDEELK 2254

  Fly  1857 QAAEKL-----------TRMRFQLQLHSTEDQKRPIQQKQTVIRSLLMKIRSLEKDTHMISKERI 1910
            :..|||           || :|...||.:|.....::::....||||..|..|  |...|..||:
Yeast  2255 KYIEKLIIGYDIYDTAQTR-KFVNDLHDSEQILAVVEKELLFKRSLLDDIGKL--DLSNIHNERM 2316

  Fly  1911 EDGDSLELRQEYDHVQQMIRESKEELNTFSEDLDMMLLCYKETQLSQLSKISNVRSDESVTMVRT 1975
            .     :|.:.|  :.:.:..|..  |.:.....:..:...||.|..|.||     |:....:..
Yeast  2317 H-----QLLRLY--ILRKVFTSNG--NNYINRTLVWNIKVNETILHLLDKI-----DKPFLDIAV 2367

  Fly  1976 NEICFKRAQWRLTETDGQIGIADLVLSAFLYTKKSKSDDSVEHLLELG-NIRMENLLPREIYRDV 2039
            .::.|:|.|    .|.|              .:|:.....:..:.:|| |:....:|...|....
Yeast  2368 AKLNFQRIQ----HTMG--------------LRKNTVTVKMMQIFDLGENVNYHCILGPLITSSG 2414

  Fly  2040 LLATEIQKDMPVDTHKRVLRIFCREKAPVGGISVKEHFEINVAPITI-----AITKKFYSTMLKF 2099
            .....:..|:|      :::|......|||||.|.::.|..::.:||     .:.|.|....||.
Yeast  2415 NDTVGLASDVP------LVQITWDVDKPVGGIKVVKNVETTLSSLTIKLEEDRLNKLFEWLSLKE 2473

  Fly  2100 CFPDRDASETEVSDELDDNASTSSASTTNLQAKSSTSSSTKRSGKGKKGAKDSEFYVKIEKDDVE 2164
            ...|.:..:       ||.||            |.....:..|.:||     .||...|..|..|
Yeast  2474 LIYDGNGDD-------DDGAS------------SIFDMVSSESEEGK-----IEFSEDISSDFNE 2514

  Fly  2165 KMKERAEKNKLFIYIKIPEVPVRVSYKGNKEKNLEDITDYSLVIPTLEYHNVTWTWLDLLLAMKS 2229
            .:| |:....:...:|:....:.:||||..:..|.::|::....|||...|.|....|||||:|.
Yeast  2515 MLK-RSSDYMIVEDLKLNSFKLCISYKGKGKMRLANVTNFVFNFPTLRLSNQTLRVTDLLLALKK 2578

  Fly  2230 VSRRVIFSQA---IKQKLHIHQRQ 2250
            |..:|:....   |..||..:.::
Yeast  2579 VLIKVLIKHTGRFIGNKLKRNSKE 2602

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hobNP_001303402.1 Fmp27 26..666 CDD:287333 134/740 (18%)
DUF2405 <887..959 CDD:287288 24/80 (30%)
Fmp27_GFWDK 1071..1203 CDD:287336 43/157 (27%)
Apt1 1774..2239 CDD:287340 112/484 (23%)
FMP27NP_013559.1 Fmp27 19..921 CDD:402110 176/1056 (17%)
DUF2405 938..1100 CDD:402076 38/169 (22%)
Fmp27_SW 1178..1278 CDD:402084 17/104 (16%)
Fmp27_GFWDK 1298..1456 CDD:402113 43/163 (26%)
Fmp27_WPPW 1717..2173 CDD:402121 81/476 (17%)
Apt1 2185..2588 CDD:402116 116/528 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C157345850
Domainoid 1 1.000 59 1.000 Domainoid score I2587
eggNOG 1 0.900 - - E1_KOG1910
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 122 1.000 Inparanoid score I1295
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0003609
OrthoInspector 1 1.000 - - otm46799
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR15678
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1822
SonicParanoid 1 1.000 - - X2484
TreeFam 00.000 Not matched by this tool.
1010.010

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