DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hob and AT5G49680

DIOPT Version :9

Sequence 1:	NP_001303402.1	Gene:	hob / 38395	FlyBaseID:	FBgn0035420	Length:	2300	Species:	Drosophila melanogaster
Sequence 2:	NP_001078738.1	Gene:	AT5G49680 / 835031	AraportID:	AT5G49680	Length:	2587	Species:	Arabidopsis thaliana

Alignment Length:	2762	Identity:	535/2762 - (19%)
Similarity:	968/2762 - (35%)	Gaps:	844/2762 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LQLLLFCLALFIFVYWV----LP------TGIS-------WYLVKRFRVKVRIGRISLPYLSLKN 50
            |.:.:|.:|||:.:.||    ||      .||:       |..:|...::.:.|       |:::
plant     5 LVMFIFTIALFVALLWVFFKSLPWILRHSAGITLSFQFDGWNCLKDVALQFKKG-------SIES 62

  Fly    51 VHIS--KSGFSVQIEEVCLRSSFFTTEVTKLLSIYIRDIRI-NKDIHSRQDDSYDQDSYELRRTQ 112
            :.|.  |:..|..:.|:|  ::.|..:...:.||.  |::| .:..||.:..         |:.:
plant    63 IVIGEFKANLSQSLVELC--ATAFIQDPKVIFSIC--DLKIVTRPSHSSKGP---------RKPK 114

  Fly   113 TLAGKASEAKGVPDFRQTKVPASIITFA---QFMAVHVNNISVVLMNNDFDPGWFIHATA--KEL 172
            | ...:|..||           .::.||   :|.:|.:.|:.|....          |||  |||
plant   115 T-RKSSSGGKG-----------KLMLFANIGRFFSVSMTNMVVQTPK----------ATAEIKEL 157

  Fly   173 HLD-------GSIVQNARVLLVNAAL---------------------------SEAQAKMLRHCS 203
            .||       |:......:|.:...:                           :|..:....||.
plant   158 ELDLSKDRGSGNFFMKLYLLPIFVQIGEPHVTSTHSPEMDSDICLARQTPSKTAEGSSSSSFHCE 222

  Fly   204 SRRQSLE---NLNKIRPCLGEVSFDMTLDASLFAQGPLSMDTLSLVINNAKSVIHGGLYEFLSEA 265
            ....|.|   | .|..|.:..|..|:       |...|:::. .|::.|..|.......|.:..:
plant   223 KISLSCEFGPN-RKSSPSIKNVEVDL-------ANAVLNLNE-KLLLKNKSSTSAASKGEVIDSS 278

  Fly   266 KRRTSTGQPSRRSTQGLA-------PSKRSYDNDNYEKLAPIIPKNFNFSI------------KA 311
            ...|::.:|.::....|.       |.|..:|....|  ...:.:..:|||            |:
plant   279 SGNTTSEKPPKQPMNVLVAKHASKFPEKVLFDLTKLE--IRFVHQEHDFSIANSIKGFQLRSAKS 341

  Fly   312 ATFSAVKENSQNDFSAKLQ----------------SFQISGKFNSKVTDEKTLLPSMLAKLG--F 358
            .:....||::..||:.:||                .|.:..|....:.:...:...:..|||  .
plant   342 QSGEDGKEDTCLDFAMELQEMHLFRESEVSVLEMTKFGVFTKVYCPIQESLPVRAEVEIKLGGIM 406

  Fly   359 HHLDIDTKYEKLLFVEQFTIDSVLEKDIFNLYVKLKT--FQ---------------IIYN--HSE 404
            .:: |.|::|.||.:.......::.|:......|.:|  |:               ::||  .|.
plant   407 SNI-IMTRFEPLLRLHFSRKKKMVLKEERPTIAKSETTGFKAVVWKCATSAPDVTVVLYNPGGSP 470

  Fly   405 IYDFVNNNF--LARQRSSEAQPMQLIHKQKSL---PDH----------LDLDTAVQSNLRANQRR 454
            ||....::|  .|...|:....:|:...:.:|   .:|          |:.|.....|:|..:.
plant   471 IYQCGLDSFQATANNMSNRGTVVQMELNELTLCMVDEHKGCLKESLFGLESDPGSLINIRKVRS- 534

  Fly   455 EGGVLEWIMQRIVVKGCAELFNVSLLMKLEDEHIAMSVSHTRFLLEQIEEKRSNLYENKFLNLLL 519
                 ||..:.::.:|.......:|::.:.:                             :.||.
plant   535 -----EWGKKEVLPEGDGSKGKQTLVVDVSE-----------------------------IGLLF 565

  Fly   520 NQRQWSME-LMVETLWS-----NLGNSINDTNNLKKTHSPGSPFFLGVSLVKL------CSYANT 572
            :.|  |:| |.|..:.|     :|..|.:.....|..|....|...|..|:||      .::|..
plant   566 SFR--SVEALTVNAISSQAYIKSLTGSSSKNKQEKGAHRSKPPSGRGTQLLKLNVERFSLNFAGD 628

  Fly   573 TKLDISV--HTFRTEYSMQLAEFVVKSMECLRQYRGIKPKNMSGQSHARPNAGLTLSVQPSQSST 635
            :.|:.:|  ...|..|..|....::               ::|.....|     |.||    .||
plant   629 SSLENTVIDDPKRVNYGSQGGRIII---------------SVSADGSPR-----TASV----FST 669

  Fly   636 SLRVSVKVKDITAYFVNHHNVYSLLSFSELNLSRSQSLTTLKLEE----FQMAIMRSMTASSLCL 696
            ......|:|    |.::    :.:|.|. ..|::....|.::||.    :|..:......|.:.|
plant   670 LSEEHEKLK----YIIS----FEILKFG-FTLNKEIQSTQVELETAKAIYQEFLEEPHQVSRVTL 725

  Fly   697 TDFSDVFATCKMIRLEHEQVEGTMGK----LSIYIPGNMEATWNSNLH-------MHLLTLV--- 747
            .|..:    .|.:|    ::.|  ||    .|::...|:...|..::|       :.|.:||
plant   726 CDIQN----AKFVR----RIGG--GKEVSICSLFSASNIAVRWEPDVHISMVELGLRLKSLVLTQ 780

  Fly   748 -------RDMQDLKTELAIPASSVKKTTPKEGFIVELSAERSTIFEIKFSDRHSIQIFVESLFFS 805
                   |:.::..|...........|||..   ::...::.:||.:   |...:.|..|:
plant   781 KLKQHGNRNPEEASTVTGDKQKEEPTTTPNS---LDKKKKKESIFAV---DVEMLSITAEA---- 835

  Fly   806 QKERCIIYAENVFVKIDDQHIFTVKELDLQSVPRLEVLTQERQNFPGFQL--------PSNKVWV 862
                    .:.|..::..|.||:      ::| .:.||.:      ||.|        .|::|.:
plant   836 --------GDGVEAEVQIQSIFS------ENV-GIGVLLE------GFMLGFCGCRIVKSSRVQI 879

  Fly   863 TTIGSFKAI----------FPYDH-----DFY---------NAVNGECTSHFKWLKMVHNYKKK- 902
            :.|.|..:.          .|:|.     |.:         .|::.......:.||:|.|.|.|
plant   880 SRIPSMPSTSSSVTPATGGTPWDWIVQGVDIHICMPFRLQLRAIDDAVEEMLRALKLVTNAKTKL 944

  Fly   903 --PFTVDSPLPCD--------LVIKIKEFLLEISDDPFEVKLRDNYVLLVDEYLESLKRKALFDK 957
              |...:|..|..        :...|::.:.:|.::|.:..|.::|.|:..|..|    .|:..|
plant   945 IFPIKKESSTPKKPGSKKVGRIRFGIRKLIFDIEEEPLQGWLDEHYHLMRKEAYE----LAIRSK 1005

  Fly   958 KIGELCSERLLLPS------------------------GTIEGLYANLVKKNSEIYIQRSKKIRE 998
            .:.||.|....:|.                        ..|:.:...|.|::...|.:..:.:|.
plant  1006 FLDELMSSGNQVPKTGGDESDGEKKISFEGEEIDPQDPAIIQMMNEKLYKQSFSSYYKSCQSLRL 1070

  Fly   999 S----------------GPVRTRLLAWIMTDVNIMAMADTSIHGYN-NVTRIMREIDHESPWPEE 1046
            |                ...||.||:..:||:::..   |:|.|.. .:..|::::|   |..||
plant  1071 SDGSGACKEGFQAGFKMSTSRTSLLSVSVTDLDLSL---TAIGGGEAGMIEIVKKLD---PVAEE 1129

  Fly  1047 -GLEFSTLWCRGVNISCTEWKFMLRDFPQPMFCVKSMRLYGNLCGAEQMGSKRAK--RDVFID-- 1106
             .:.||.|:...:.::.......:|::..|:......:..|.|..|:|..:.:.:  .||:|.
plant  1130 KDIPFSRLYGSNLRLNTGTLAVQIRNYTFPLLSTAFGKCEGCLVLAQQATAFQPQIIHDVYIGRW 1194

  Fly  1107 -----VGEPFGTDVIQRSMPSLKFYHDFDCELESCSYAFGACWEPVMA-----------QCNLSF 1155
                 :....||      .|::|.|.|...:.:....:||..:|||:|           :.|||.
plant  1195 RKVQMLRSASGT------TPAMKTYLDLPIKFQKGEISFGIGYEPVLADISYAFTVALRRANLSL 1253

  Fly  1156 E---KISAPSKDPSPPLPFWDKLRLLLHGRLTLIAKQFTILLHASLDPYNTTEEMELTWNNCGIV 1217
            :   .:..|.|:.|  ||:||::|..:||.:||...:...::..|.|||...:::.:|..:..|.
plant  1254 KGPGLLQPPKKEKS--LPWWDEMRNYVHGNVTLSFSETKWIVLGSPDPYEKLDKLHMTSGSVEIQ 1316

  Fly  1218 LTNAKIMFKGELNVTVRTASRYDDCRLLHFPN---------------LKLTIKLKWVC-LANPND 1266
            ..:.::.|..| ::.:..:|.....|  |:||               ..|.:::.|.| ..:|.:
plant  1317 QYDGRVHFSAE-DIKIFFSSFEGLAR--HYPNSPVCPSSYPFLEVPRFSLEVRMDWECESGSPLN 1378

  Fly  1267 HHA-VMPC---APDKLPEYSSNQVHDSFRAFRSLNLNIWISFETKP------------KAGEDLE 1315
            |:. .:|.   |.||:           :..|||.:|::...|..:|            |.|.:.:
plant  1379 HYLFALPIEGKARDKI-----------YDPFRSTSLSLRWDFTLRPENPSVSAVDQTKKVGSECK 1432

  Fly  1316 VD-----IPSLVLYGSTLRW---FESLQLILSGVTRPTRRGPVFNNVR-PRKKPLS--RHYKKAN 1369
            .:     .|::.:....|.|   |.::..:.....|...|.|.|...| ||...||  |...:.|
plant  1433 PEKSSFSPPTINIGAHDLAWLIRFWNMNYLPPYKLRTFSRWPRFGVPRIPRSGNLSLDRVMTEYN 1497

  Fly  1370 LQM-----CLHKFQVLYWMSHALQKG-------------FQLNGRRVSFSSEHSLTLNPIDDGL- 1415
            |::     |: |...|  .|:...||             |....:..:|..:.. ||:|:..|:
plant  1498 LRLDVTPICI-KHMTL--DSNNPAKGLTFDMTKLKYEICFSRGNQDFTFECKRE-TLDPVYQGID 1558

  Fly  1416 IHRPRA----DWSTIYMNCELNDAEIWLKSILTEKMDS-SSENLASAA--------DAFKIVRFY 1467
            :|.|:|    |     .:|. ..|::...|.|:...|. :|:|..|.:        |.|.....|
plant  1559 LHLPKAFLRRD-----QHCS-KPAQMSRTSSLSGSTDRVTSDNGTSTSDGTEKHPDDGFLFSSDY 1617

  Fly  1468 F-------------LSVAKVS---YGREALIPTTATSTEEDVKAQSTTPT-------------HK 1503
            |             |.|.|..   |..:....:|.....|..:...:.|:             .:
plant  1618 FTIRRQAPKADPERLMVWKEEGKIYREKVDARSTKEKQSEPEENSHSDPSDDDGYNVVIADNCQR 1682

  Fly  1504 LVVYDLKGAWTKSNRDVAFALFDSFMKS-QKLKNNLSTEAVKSYRKEGPNSAVLKHKRSDSTITL 1567
            :.||.||..|...|||...:......|: |..|.:.|.:..:....||      ..|.|:|.::.
plant  1683 IFVYGLKLLWNIENRDAVLSFAGGMSKAFQPPKPSPSRQYAQRKLLEG------NQKHSESEVSQ 1741

  Fly  1568 SSTNNEVLPISNPNASMKKAPAQIHATAMLQQLIAEADHKFNVYSDDHSTQS-RELQLQGLQACS 1631
            .....:....|...||..|.||::.:.:                |:...|:: ....|...:...
plant  1742 DEPTKQPSTGSGNLASQSKEPAEVLSPS----------------SEPIKTENFASFPLGATKTGD 1790

  Fly  1632 AQDIIHE---NWSISLVNSQVLLKGCETSGYVIISAAKAEILQRE-HRPVWRERSLISKTTWKGL 1692
            :.|...|   ::.:::|..|..|...:.:|..:::||...:|.|. |..|.....:|.|
plant  1791 SNDPEEEGTRHFMVNVVEPQFNLHSEDINGRFLLAAASGRVLARSFHSVVHVAYDMIEK------ 1849

  Fly  1693 LECMQYYATVSAGDNNSLLEKEIMW------LTVDNIQ------DKDETV-INNLPDISHLVGSG 1744
                   |..:..|:|.....::.|      :.::::|      |.|... :..||.|.......
plant  1850 -------AAQNENDHNPENGTDMTWTRMEVSMMLEHVQAHVAPTDVDPGAGVQWLPKIRRSSPKA 1907

  Fly  1745 RSVGGVVSETVGAFLSDNSGGAQPVQLQRIVSKCKCEFFYVSYGDAIDPNSITEVPPPPSEELQS 1809
            :..|.:                    |:|:...|...|.|..: ..:.|    ::...|.:||
plant  1908 KRTGAL--------------------LERVFMPCDMYFQYTRH-KGVTP----DLKVKPLKEL-- 1945

  Fly  1810 PWEKQDDPVDAFTLMHHDLDVCTNSLQYAMILDIVNNLLLYVEPQR-----KQAAEKLTRMRFQL 1869
                        |....::.....|.|:.::.|:::|||....|:.     |.:.|:...:..::
plant  1946 ------------TFNSRNITASMTSRQFQVMTDVLSNLLFARLPKAHNDSLKLSGEEDDEVEEEI 1998

  Fly  1870 Q------LHSTEDQKRPIQQKQTVIRSLLMKIRSL--------------EKDTHMISKER---IE 1911
            .      :...|..|..::.|:.....||..||.|              |.|..|||..|   :|
plant  1999 DEVVPDGIEEVELAKIELEAKERDRMMLLDDIRKLTQNESNSGNINLEKESDFWMISGGRPVLVE 2063

  Fly  1912 DGDSLELRQEYDHVQQMIRESKEELNTFSEDLDMMLLCYKETQLSQLSKISNVRSDESVTM-VRT 1975
                 .||:.|..|||..:.:...|.|..::         ..:|..|.|..|.|...::.: ::.
plant  2064 -----RLRKAYLSVQQSRKTAYTALRTSVKN---------AAELRLLEKDKNKRPSSAMRISLQI 2114

  Fly  1976 NEICFKRAQWRLTETDGQIGIADLVLSAFLYTKKSKSDDSVEHLLELG-------NIRMENLLPR 2033
            |::.     |.:. .||:. .|::.:...:|       |......::|       .:.:.|.||.
plant  2115 NKVI-----WSMV-LDGKT-FAEVEIDNMIY-------DFNRDYRDIGIAQFTTRYVVLRNCLPN 2165

  Fly  2034 EIYRDVLLATEIQKDMPVDTHKRV-LRIFCREKAPVGGISVKEHFEINVAPITIAITKKFYSTML 2097
            .....||.|.    :.|.:..|:| |::..|:.||..|.:..|.|::.:.|:.|.:|:..|:.|.
plant  2166 AKCDTVLSAW----NPPPEWGKKVMLQVDARQGAPKDGQAPYELFQVEIYPLKIHLTETMYTMMW 2226

  Fly  2098 KFCFPDRDASETEVSDELDD--NASTSSAS-----------------------TTNLQAKSST-- 2135
            ::.||    .|.:.|...::  ..||:|.|                       :.|...||||
plant  2227 EYIFP----GEEQHSQRREEVWKVSTTSGSRRRKGSFAQEAAALLAASDLGQGSKNQSLKSSTIR 2287

  Fly  2136 -----------------------------SSSTKRSGKGKKG-AKDSEF------YVKIEK---D 2161
                                         .||.:..|:..|| .|||:.      .|..||   .
plant  2288 GSGRELRRTSSFDRSWEETVAESVATELVLSSMEHQGESSKGKLKDSKTSKAGGRSVHEEKKGEK 2352

  Fly  2162 DVEKMKERAEKNKLFIYIKIPEVPVRVSYKGNKEKNLEDITDYSLVIPTLEYHNVTW--TWLDLL 2224
            .:|..|.|.:|...|..|||.:|.:.::|:|::..    :.|..|.:.|  :|.|.:  ||..|
plant  2353 SLEDKKSRPQKIMQFQTIKISQVELLITYEGSRFV----VNDMKLCMDT--FHRVEFSGTWRRL- 2410

  Fly  2225 LAMKSVSRRVIFS----------QAIKQKLHI 2246
              ...|.:.:|:.          :..|.|.|:
plant  2411 --FSRVKKHIIWGVLKSVTGMQMKKFKDKAHV 2440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hob	NP_001303402.1	Fmp27	26..666	CDD:287333	138/769 (18%)
		DUF2405	<887..959	CDD:287288	19/82 (23%)
		Fmp27_GFWDK	1071..1203	CDD:287336	39/154 (25%)
		Apt1	1774..2239	CDD:287340	119/579 (21%)
AT5G49680	NP_001078738.1	Fmp27_GFWDK	<1206..1301	CDD:287336	29/102 (28%)
AT5G49680	NP_001078738.1	Apt1	1917..2426	CDD:287340	119/572 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	46	1.000	Domainoid score	I4586
eggNOG	1	0.900	-	-		E1_KOG1910
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	111	1.000	Inparanoid score	I2062
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3151
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR15678
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.050