Protein Alignment hob and 2610507B11Rik

DIOPT Version :9

• Sequence 1: NP_001303402.1
• Gene: hob / 38395
• FlyBaseID: FBgn0035420
• Length: 2300
• Species: Drosophila melanogaster
• Sequence 2: NP_001002004.2
• Gene: 2610507B11Rik / 72503
• MGIID: 1919753
• Length: 2234
• Species: Mus musculus
• Alignment Length: 2447
• Identity: 775/2447 - (31%)
• Similarity: 1207/2447 - (49%)
• Gaps: 373/2447 - (15%)

  Fly     2 MLQLLLFCL-ALFIFVYWVLPTGISWYLVKRFRVKVRIGRISLPYLSLKNVHI--SKSGFSVQIE 63
            :|.|||..| |||:..:.|:.....| ..::.:.:::||  |..:..::||.:  .:...:|:|:
Mouse     8 LLVLLLVALSALFLGRWLVVRLATRW-CQRKLQAELKIG--SFRFFWIQNVSLKFQQHQQTVEID 69

  Fly    64 EVCLRSSFFTTEVTKLLSIYIRDIRINKDIHSRQDDSYDQDSYELRRTQTLAGKASEAKGVPDFR 128
            .:.:.|...:.::...:::...::||..|               |::..:|:...|:...|....
Mouse    70 NLWISSKLLSHDLPNYVALCFGEVRIRTD---------------LQKVSSLSAPFSQNTEVEQKE 119

  Fly   129 QTKVPASIITFAQFMAVHVNNISV-VLMNNDFDPGWFIHATAKELHLDGSIVQNARVLLVNAALS 192
            .:..|:.:..|.|..::||:.|:: ||.....:..|.|..:.....||    .:.:.|:....||
Mouse   120 LSLSPSLLKIFCQLFSIHVDAINIMVLKVATSESLWHIQISRSRFLLD----SDGKSLICKVNLS 180

  Fly   193 EAQAKMLRHCSSRRQSLENLNKIRPCLGEVS--FDMTLDASLFAQGPLSMDTLSLVINNAKSVIH 255
            :..:|:|     :...||:     .||.|:|  .|:.|..|: :...|:..|:.:...:|:  :|
Mouse   181 KINSKVL-----KSGQLED-----TCLVELSLALDLRLQVSV-SSWHLTAVTVDVWTLHAE--LH 232

  Fly   256 GGLY--EFLSEAKRRTSTGQPSRRSTQGLA-PS--------------KRSYDND------NYEKL 297
            .||:  :.|..|..|.|........|:..| |:              |...:|.      |.:|
Mouse   233 EGLFHSQLLCHAPGRISKSVSCSDLTENFAEPTLPGLYLLQRLPDQVKVKMENTSVVLSMNSQK- 296

  Fly   298 APIIPKNFNFSIKAATFSAVKENSQ---NDFSAKLQSFQIS-------GKFNSKVTDEKTLLPSM 352
                 ::..:::|...|...::..|   ..|:|.....|:|       |...|:.......|.|:
Mouse   297 -----RHLTWTLKLLHFLYHRDEDQLPLRSFTANYDMAQMSTELLLEDGLLLSQSRQRIVCLNSL 356

  Fly   353 LAKLGFHHLDIDTKYEKLLFVEQFTIDSVLEKDIFNLYVKLKTFQIIYNHSEIYDFVNNNFLARQ 417
            .|.                 |:..|||       .:..:.|.|..|.|.|.|...::  ..||.:
Mouse   357 KAN-----------------VQVTTID-------LSASLVLNTCIIHYRHQEFSHWL--LMLALE 395

  Fly   418 RSSEAQPMQLIHKQKSLPDHLDLDTAVQSNLRANQRREGGVLEWIMQRIVVKGCAELFNVSLLMK 482
            ....:.|.....|:::.|.                         |:..|:..  ..:.|||:.::
Mouse   396 TQGASSPDLKQRKKRTFPQ-------------------------ILAPIIFS--TSVSNVSISIQ 433

  Fly   483 LED--------EHIAMSVSHTRFLLEQIEEKRSNLYENKFLNL------------------LLNQ 521
            |.|        ..|::...|.|         ..::::...|.:                  ..|.
Mouse   434 LGDTPPFALGFNSISLDYQHLR---------PQSIHQRAVLTVDHLCWRVGSDSHIQRAPHPPNM 489

  Fly   522 RQWSMELMVETLWSNLGNSINDTNNLKKTHSPGSPFFLGVSLVKLCSYANTTKLDISVHTFRTEY 586
            ..|...|::::.  .|..|.|....|..|.|                  ||..||.::...:.|.
Mouse   490 HVWGEALVLDSF--TLQGSYNQPLGLSSTQS------------------NTLFLDCTIRGLQVEI 534

  Fly   587 SMQLAEFVVKSMECL-RQYRGIKPKNMSGQSHARPNAGLTLSVQPSQSSTSL-RVSVKVKDITAY 649
            |...|       :|| |....:.|::.......:.:.|        :|.|.| :|.:||:|:..:
Mouse   535 SDICA-------QCLSRVLSLVIPQSERSAVSRKSSLG--------ESVTLLWKVDLKVEDMNLF 584

  Fly   650 FVNHHNVYSLLSFSELNLSR-----SQSLTTLKLEEFQMAIMRSMT--ASSLC-LTDFSDVFATC 706
            .::     :|:..|||.|..     |...:|:.::...:|:::|:|  ....| ..|........
Mouse   585 TLS-----ALVGASELRLDTLTVLGSAETSTVGIQGLVLALVKSVTEKMQPCCKAPDIPTPVLGL 644

  Fly   707 KMIRLEHEQVEGTMGKLSIYIPGNMEATWNSNLHMHLLTLVR---DMQDLKTELAIP--ASSVKK 766
            .|:.|.:   ..::..|.:.....:...|:...||:|...||   ..:||......|  ..|...
Mouse   645 SMLSLTY---HSSIRSLEVQCGAGLTLLWSPPDHMYLYQHVRATLQCRDLLRATVFPEIIESHSL 706

  Fly   767 TTPKEGF------------------IVELSAERSTIF--EIKFSDRHSIQIFVESLFFSQKERCI 811
            .||:..:                  .:|:|..:.|.|  |.||     |.:..||:..::....:
Mouse   707 NTPQSTWEPEDHLPESSLPRRLLTLTLEVSTAKLTAFVAEDKF-----ITLAAESVSLNRHGGSL 766

  Fly   812 -IYAENVFVKIDDQHIFTVKELDLQSVPRLEVLTQERQNFPGFQLPSNKVWVTTIGSFKAIFPYD 875
             .|...:....|...||.:||:::|.:|.||.:...|..||..|...|:||:.::||....|||.
Mouse   767 QAYCPELAAGFDGNSIFNLKEVEVQLLPELEEMILHRNPFPALQTLRNRVWLLSLGSVSVEFPYQ 831

  Fly   876 HDFYNAVNGECTSHFKWLKMVHN-----YKKKPFTVDSPLPCDLVIKIKEFLLEISDDPFEVKLR 935
            :||...:: |.....||||.:|.     ....|    :|||.||::|::.|.....||.|||||.
Mouse   832 YDFSRTLD-EAVGVQKWLKGLHRGTHAWASPSP----APLPPDLLLKVQHFSWVFLDDIFEVKLH 891

  Fly   936 DNYVLLVDEYLESLKRKALFDKKIGELCSER-LLLPSGTIEGLYANLVKKNSEIYIQRSKKIRES 999
            |||.|:.||..||.||..|.|.|:..|..:. .|||:..||.|||:|.:||.|||||||:::..:
Mouse   892 DNYELMKDESKESAKRLQLLDAKVAALRKQHGELLPARKIEELYASLERKNIEIYIQRSRRLYGN 956

  Fly  1000 GPVRTRLLAWIMTDVNIMAMADTSIHGYNNVTRIMREIDHESPWPEEGLEFSTLWCRGVNISCTE 1064
            .|:|..||.|.:..:.::|:||.|.||..:|...:||:|..||:|.||::..|.|||.:..:...
Mouse   957 TPMRRALLTWSLAGLELVALADASFHGPEHVIEQVRELDPGSPFPAEGMDLVTQWCRMLKCNVKT 1021

  Fly  1065 WKFMLRDFPQPMFCVKSMRLYGNLCGAEQMGSKRAKRDVFIDVGEPFGTDVIQRSMPSLKFYHDF 1129
            :...:||:|:.:|.::..||.|.|.|.||.|...::|...:.:|.|:|...::|:||.|||||||
Mouse  1022 FLVRIRDYPRYLFEIRDWRLMGRLAGTEQSGQPCSRRRQILHLGLPWGNVAVERNMPPLKFYHDF 1086

  Fly  1130 DCELESCSYAFGACWEP---VMAQCNLSFEKISAPSKDPSPPLPFWDKLRLLLHGRLTLIAKQFT 1191
            ..|:...:..:|.||:|   ::.||   .:.::.||.|||||||:|||.|||.||...:..:|..
Mouse  1087 HSEIFQYTVVWGPCWDPAWTLIGQC---VDLLTKPSADPSPPLPWWDKSRLLFHGDWHMDIEQAN 1148

  Fly  1192 ILLHASLDPYNTTEEMELTWNNCGIVLTNAKIMFKGELNVTVRTASRYDDCRLLHFPNLKLTIKL 1256
            :...|:.|||||||.|...|::........:.:|:|:|:|.|||||:||||..||.|:|.:|:.|
Mouse  1149 LHQLATEDPYNTTENMHWEWSHLSFHWKPGQFVFRGDLDVNVRTASKYDDCCFLHLPDLCMTLDL 1213

  Fly  1257 KWVCLANPNDHHAVMPCAPDKLPEYSSNQVHDSFRAFRSLNLNIWISFETKPKAGEDLEVDIPSL 1321
            :|:|..||:|||:|...||:.|||....|:|||:|||||.|||:.|..:....:|   .:..|.:
Mouse  1214 QWLCHGNPHDHHSVTLRAPEFLPEVPLGQLHDSYRAFRSENLNLSIKMDLTRHSG---TISQPRI 1275

  Fly  1322 VLYGSTLRWFESLQLILSGVTRPTRRGPVFNNVRPRKKPLSRHYKKANLQMCLHKFQVLYWMSHA 1386
            ::|.|||||.::.....:.:|||..||.:|||::|.||.|.:|||:.:......:.||.||.|.|
Mouse  1276 LVYSSTLRWMQNFWATWTSITRPICRGKLFNNLKPSKKKLGQHYKQLSYTALFPQLQVHYWASFA 1340

  Fly  1387 LQKGFQLNGRRVSFSSEHSLT-----LNPIDDGLIHRPRADWSTIYMNCELNDAEIWLKSILTEK 1446
            .|:|.|     :..|..|..|     |.|....::.|..::||...|..:|:...:.|.:..||
Mouse  1341 QQRGIQ-----IECSQGHVFTRGTQRLIPQAGTVMRRLISEWSVTQMVSDLSQVTVHLMASPTE- 1399

  Fly  1447 MDSSSENLASAADAFKIVRFYFLSVAKVSYGREALIPTTATSTEEDVKAQSTTP---THKLVVYD 1508
                 ||.....|.. |.:.:.||::.::|.|.     :..:|||::.|:...|   ||:|.:.|
Mouse  1400 -----ENADHCLDPL-ITKTHLLSLSSLTYQRH-----SNRTTEEELSARDGDPAFHTHQLYLVD 1453

  Fly  1509 LKGAWTKSNRDVAFALFDSFMKSQKLKNNLSTEAVKSYRKEGPNSAVLKHKRSDSTITLSSTNNE 1573
            |:.:||.:|||:||.|:|.:.|:..||.||||||:|.. |..|..:..|.||.   |..|:   :
Mouse  1454 LRISWTTTNRDIAFGLYDGYKKAAVLKRNLSTEALKGL-KIDPQMSAKKPKRG---IPPSA---Q 1511

  Fly  1574 VLP-ISNPNASMKKAPAQIHATAMLQQLIAEADHKFNVYSDDHSTQSRELQLQGLQACSAQDIIH 1637
            |.| :|.|:.|.:..........|||:||.|.| :|.|::::.|..|.  ||.|:.||...||.:
Mouse  1512 VPPHVSTPSFSGRPDKGSSGGAYMLQKLIEETD-RFVVFTEEESGMSD--QLCGIAACQTDDIYN 1573

  Fly  1638 ENWSISLVNSQVLLKGCETSGYVIISAAKAEILQREHRPVWRERSLISKTTWKGLLECMQYYATV 1702
            .|..|.|||.|::|:|.||.|.||:|||||::||.:|.|.|...:|..||:|..||:.|||:||.
Mouse  1574 RNCLIELVNCQMVLRGAETEGCVIVSAAKAQLLQCQHHPAWYGDTLKQKTSWTCLLDGMQYFATT 1638

  Fly  1703 SAGDNNSLLEKEIMWLTVDNIQDKDETVINNLPDISHLVGSGRSVGGVVSETVGAFLSDNSGGAQ 1767
            .:.....  :...:||.|.||::..|   .:|..:..|:.||::|||:|:.|..  .:..:...|
Mouse  1639 ESSPTEQ--DGRQLWLEVKNIEEHRE---RSLDSVQELMESGQAVGGMVTTTTD--WNQPAEAQQ 1696

  Fly  1768 PVQLQRIVSKCKCEFFYVSYGDAIDPNSITEVPPP---PSEELQSPWEKQDDPVDAFTLMHHDLD 1829
            ..|:|||:|:|.|..:|:||...|||...|::.||   .::|.:...:||:..||.|||:||:|:
Mouse  1697 AQQVQRIISRCNCRMYYISYSHDIDPELATQIKPPEVHENQEKEDLLKKQEGAVDTFTLIHHELE 1761

  Fly  1830 VCTNSLQYAMILDIVNNLLLYVEPQRKQAAEKLTRMRFQLQLHST-EDQKRPIQQKQTVIRSLLM 1893
            :.||..||||||||||||||:|||:||:.:||..|:||||::.|. |:|:..|...|..:|..:.
Mouse  1762 ISTNPAQYAMILDIVNNLLLHVEPKRKEHSEKKQRVRFQLEISSNPEEQRSSILHLQEAVRQHVA 1826

  Fly  1894 KIRSLEKDTHMISKERIEDGDS---LELRQEYDHVQQMIRESKEELNTFSEDLDMMLLCYKETQL 1955
            :||.|||..:.|.|...:|..:   |:|.|:   :|..:.:.|..|...||:|::::.|:|:.||
Mouse  1827 QIRHLEKQMYSIMKSLQDDSKNENLLDLNQK---LQLQLNQEKANLQLESEELNILIRCFKDFQL 1888

  Fly  1956 SQLSKISNVRSDESVTMVRTNEICFKRAQWRLTETDGQIGIADLVLSAFLYTKKSKSDDSVEHLL 2020
            .:.:|:...:..|.|::||..|..|.:|:|||||.|||:|||:|.|..|||:|.:||||:.||||
Mouse  1889 QRANKMELRKQQEDVSVVRRTEFYFAQARWRLTEEDGQLGIAELELQRFLYSKVNKSDDTAEHLL 1953

  Fly  2021 ELGNIRMENLLPREIYRDVLLATEIQKDMPVDT----HKRVLRIFCREKAPVGGISVKEHFEINV 2081
            |||...|.||||..||:.||        .|..:    .:..||:|.:.:.||||||||||||:||
Mouse  1954 ELGWFTMNNLLPNAIYKVVL--------RPQSSCQSGRQLALRLFSKVRPPVGGISVKEHFEVNV 2010

  Fly  2082 APITIAITKKFYSTMLKFCFPDRDASETEVSDELDDNASTSSASTTNL------QAKSSTSSSTK 2140
            .|:||.::.:|:..|:.|.||.|:..:.||.||.|    .|...||.:      |..::..:...
Mouse  2011 VPLTIQLSHRFFHRMMGFFFPGRNVEDDEVGDEED----KSKLVTTGIPVVKPRQLIATDDAVPL 2071

  Fly  2141 RSGKG-------KKGAKDSEFYVKIEK---DDVEKMKERAEKNKLFIYIKIPEVPVRVSYKGNKE 2195
            .||||       ..|.:.|  :.|:.:   ||::||||||..|..|||||||:||:.|||||  |
Mouse  2072 GSGKGVAQGLTRSSGVRRS--FRKLPEHPVDDIDKMKERAAMNNSFIYIKIPQVPLCVSYKG--E 2132

  Fly  2196 KNLEDITDYSLVIPTLEYHNVTWTWLDLLLAMKSVSRRVIFSQAIKQKLHIHQRQPILSAGERAT 2260
            ||..|..|.:||:|.|||||.||||||..:|:|..||:.:.:|.||:||.:.........|:..|
Mouse  2133 KNSVDWGDLNLVLPCLEYHNNTWTWLDFAMAVKRDSRKALVAQVIKEKLRLKPATGSEVRGKLET 2197

  Fly  2261 ------PQEAEDKAVMLFGNRLLNENRNQKKGVFKFASSGKR 2296
                  .|:.|:||.:|.|..:.::|.. ||.:|     |:|
Mouse  2198 KCDLNMQQQEEEKARLLIGLSVGDKNPG-KKSIF-----GRR 2233

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hob	NP_001303402.1	Fmp27	26..666	CDD:287333	128/705 (18%)
		DUF2405	<887..959	CDD:287288	32/76 (42%)
		Fmp27_GFWDK	1071..1203	CDD:287336	54/134 (40%)
		Apt1	1774..2239	CDD:287340	213/491 (43%)
2610507B11Rik	NP_001002004.2	Fmp27	26..674	CDD:287333	142/793 (18%)
		Fmp27_GFWDK	1028..1160	CDD:287336	54/134 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1496..1529		10/38 (26%)
		Apt1	1703..2176	CDD:287340	213/491 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848666
Domainoid	1	1.000	374	1.000	Domainoid score	I876
eggNOG	1	0.900	-	-		E1_KOG1910
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H34730
Inparanoid	1	1.050	1054	1.000	Inparanoid score	I257
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46407
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003609
OrthoInspector	1	1.000	-	-		oto93579
orthoMCL	1	0.900	-	-		OOG6_106761
Panther	1	1.100	-	-	LDO	PTHR15678
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1822
SonicParanoid	1	1.000	-	-		X2484
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790