DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hob and SPAC3H5.09c

DIOPT Version :9

Sequence 1:	NP_001303402.1	Gene:	hob / 38395	FlyBaseID:	FBgn0035420	Length:	2300	Species:	Drosophila melanogaster
Sequence 2:	NP_594183.2	Gene:	SPAC3H5.09c / 2543405	PomBaseID:	SPAC3H5.09c	Length:	2699	Species:	Schizosaccharomyces pombe

Alignment Length:	2886	Identity:	549/2886 - (19%)
Similarity:	944/2886 - (32%)	Gaps:	992/2886 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 FVYWVLPTGISWYLVKRFRVKVRIG--RISLPYLSLKNV-HISKSGFSVQIEEVCLRSSFFTTEV 76
            ||:.|:.||..::|| .|.:...:|  ..:..:.|:..: |..::|.||.|..|.||....:|..
pombe    24 FVWVVIATGFLFHLV-LFVLSYVLGWPFTNFGFFSVYGLRHTFRNGDSVFISYVALRLHRPSTSK 87

  Fly    77 TKLLSIYIRDIRINKDIHSRQDDSYDQDSYELRRTQTLAGKASEAKGVPDFRQTKVPASIITFAQ 141
            ..||.|..:.:.....:.|..|......:...|.......|..|.|....|..
pombe    88 PYLLRIVTKGLIYTPSLSSANDAQSAGKNENQRSRLVFKAKREEEKTEEKFCH------------ 140

  Fly   142 FMAVHVNNISVVLMNNDFDPGW--FIHAT-AKELHLDGSIVQNARVLLVNAALSEAQAKMLRHCS 203
              ||:::|    |:.| .:..|  |:|.: .|.||:               ::.|:|...
pombe   141 --AVYMSN----LLRN-VEQKWIQFLHKSWMKWLHI---------------SIQESQLTF----- 178

  Fly   204 SRRQSLENLNKIRPCLGEVSFDMTLDASLFAQGPLSMDTLSLVINNAKSVIHGGLYEFLSEAKRR 268
                         |.:|           .|..|.|||:.
pombe   179 -------------PSVG-----------TFELGSLSMEM-------------------------- 193

  Fly   269 TSTGQPSRRSTQGLAPSKRSYDNDNYEKLAPIIPKNFNFSIKAATFSAV--KENSQ--NDF-SAK 328
                :|...:..|       |:|.:..:|   :......||:.|....:  :::||  .|: ...
pombe   194 ----RPETNNVVG-------YENPSDPEL---VSSCVICSIRLANLVYIDRRQSSQQITDYLDLS 244

  Fly   329 LQSFQISGKFNSKVTDEKTLLPSMLAKLGFHHLDIDTKYEKLLFVEQFTIDSVLEKDIFNLYVKL 393
            ||::....|  |.|.|....|.|.: |:|..::|:||.
pombe   245 LQTYYSLDK--SNVPDTILRLRSSI-KVGVLYIDLDTP--------------------------- 279

  Fly   394 KTFQIIYNHSEIYDFVNNNFLARQRSSEAQPMQLIHKQKSLPDHLDLDTAVQSNLRANQRREGGV 458
                 ::.|     .:|:|......||.:.....:|..|   |:::   |....|:..|.:.|.:
pombe   280 -----LFEH-----LLNSNSSGGNHSSSSSSSGKVHVMK---DNVE---AALLKLQEAQIQIGTL 328

  Fly   459 LEWIMQRIVVKGCAELF---------NVSLLMKLEDEH-------------IAMSVSHTRFLLEQ 501
            ..|   :..|.||...:         |:.||.|....|             :|.::|   |.:|.
pombe   329 KLW---KRNVTGCGATYILNGSDFGLNLILLNKKNPSHRMFFPVEACVHQILASALS---FNVES 387

  Fly   502 IEEKRSNLYENKFLNLLLNQRQWSMELMVETLWSNLGNSINDTNNLKKTHSPGSPFFLGVSLVKL 566
            |....|   .:..||:.|        :.:..|.|.|.....|.::|.:..:         |::::
pombe   388 ITPGHS---PHVLLNIPL--------VTITCLTSALAEYARDASDLHQLQN---------SILRV 432

  Fly   567 CSYANTTKLDISVHTFR---------------------------TEYSMQLAE----FVVKSMEC 600
            .|...:..||:.:....                           .::|:.|.|    |::.| :.
pombe   433 NSTLTSPSLDLRLELLHDVLSCFPKKHDSTSRKKPKFPYQYFPYMKFSVSLYEPALRFLIAS-KS 496

  Fly   601 LRQYRGIKPKNMSGQSHARPNAGLTLSVQPSQSST---SLRVSVKVKDITAYFVNHHNVYSLLSF 662
            ...:.|:...|:|         .:.|.::.|.||.   .:..|:::.....::.|..|...|::.
pombe   497 DSDFPGMLVANLS---------SMFLDIKYSPSSEHIFEIESSLRLSSNKVFYHNPKNKKWLINT 552

  Fly   663 SELNLSRSQSLTTLKLEEFQMAIMRSMTASSLCLTDFS--DVFATCKMIRLEHEQVEGTMGKLSI 725
            |:        |.|..|             ..:|..|..  ::|.....||:|.|:|..::.|..|
pombe   553 SD--------LITFSL-------------GYICNNDHGSLNMFFRDFQIRIEEEEVINSLKKFII 596

  Fly   726 YIPGNMEAT-------------------W--NSNLHMHLLTLV---------------------- 747
            ......|..                   |  :..|.:|.|.||
pombe   597 LTKIKSEQVGPRKPRTKLVEPLLFRIPKWLKHIQLEVHSLLLVITAIRPEISPEPRGINCSIDKI 661

  Fly   748 ------------RDMQ--DLKTELAIPASSVKKT-----------TPKEGFIVELSAERSTIF-- 785
                        :.|:  ||..||.:..|.:.|.           .|...|||......:|..
pombe   662 HSLYLNDKKSRSQGMRKFDLNLELLMIKSIIFKNGKSLNSHLFLQIPNINFIVSTILRDNTAISR 726

  Fly   786 ---EIKF-----SDRHSIQIF-----VESLFFSQKER---------------------------- 809
               ||.|     |..|:..||     ..|||...|..
pombe   727 FTTEINFLRCFASLLHNCCIFYAYRACSSLFGENKSHKRIEKTNTSPQEPGVVPEGWNFDFRLKN 791

  Fly   810 ---CIIYAENVFVKIDDQHIFTVKELD------------------------------------LQ 835
               .|...::|.:.:|.....|:|:.:                                    |:
pombe   792 ARVSIFLDDDVSLLLDCGGFTTLKKTEKKYAEMHAKFIQIHTKNSDVPTLWDRFLALGNVRYQLK 856

  Fly   836 SVPRLEVLTQERQNFPGFQLPSNKVWVTTIGSFKAIFPYDHDFYNAVNGECTSHFKWLKMVHNYK 900
            .:..||.|.|...::...::|                   |.|...:..|  |....:|......
pombe   857 DLSDLEKLHQVTCSYISIRIP-------------------HKFIPFILIE--SAINTVKAAIRVS 900

  Fly   901 KKPFTVDSPLPCDLVIKIKE-------------FLLEISDDPFEVKLRDNYVLLVDEYLESLKRK 952
            .:|.|:|.  ..||..:||:             |..|:.|||||.:|..||.:.:.|....:.|.
pombe   901 AEPLTIDQ--QHDLAEEIKQPRVVPHIQIKSTKFKFEVDDDPFECRLGMNYRIGLTEQQMRIDRW 963

  Fly   953 ALFDKKIGELCSERLLLPSGTIE--GLYAN----------------------------------- 980
            .:|:::...|...:...|....|  ..|.|
pombe   964 NIFEERANLLRKAKDPSPKSASESSSFYQNGSDIDDNDSNSSNTSNHTTENANAQQRKLEDLNRS 1028

  Fly   981 -----------------------------LVKKNSEIYIQRSKKIRESGPVR---TRLLAWIMTD 1013
                                         |::.:|..:|...|:|||....|   .|:.||..:|
pombe  1029 FEDFLGSRPTNNSSFLKNVSVDEDTAREKLMEYDSLSWISNIKRIREFRYHRLRIRRMTAWPESD 1093

  Fly  1014 V---------NIM------AMADTSIHGYNNVTRIMREIDHESPWPEEGLEFSTLWCRG------ 1057
            .         ||:      .:.|.|:..::..      :|..|...||..:|.....||
pombe  1094 ALDKHILFKENIIPIPIRPPLVDISLLNFDFT------LDKPSFPLEELPKFLNTVGRGQPLDYG 1152

  Fly  1058 --------VNISCTEWKFMLRDFPQPMFC-----------VKSMRLYGNLCGAEQMGSKRAKRDV 1103
                    ::....|.||::||:|.|:..           :.|..|..|:...||..:..|.|||
pombe  1153 YSIYFPMYIDWKMDEAKFLIRDYPLPLVYIPKLGRGQDKRISSWHLKSNMVITEQQATLAAIRDV 1217

  Fly  1104 FIDV--------GEPFGTDVIQRSMPSLKFYHDFDCELESCSYAFGACW----EPVMAQCNLSFE 1156
            .:.|        |.|:..:| .|::..:|.:...:.::.|....| ..|    :|.::......:
pombe  1218 SVKVIPADLTKEGIPYVVNV-TRTVSPIKTFSKTEIDVNSSLPTF-LLWCNSYQPALSDMTRIMD 1280

  Fly  1157 KISAPSKDPSPPLPFWDKLRLLLHGRLTLIAKQ---FTILLHASLDPYNTTEE---MELTWN--- 1212
            ..:....|||..|.||||:||:.|.::.|...:   ..:.|..|.|||....|   .:..|:
pombe  1281 TFTKMPIDPSEKLGFWDKIRLVAHSQIRLRWLEDGDVFLSLKGSRDPYVILGEGAGFQFCWSGNV 1345

  Fly  1213 ----NCGIVLTNAKIM-----------FKGELN--------VTVRTASRYDD--------CRLLH 1246
                .|.....|..|:           |..::|        .|..|...|..        ||.:
pombe  1346 SWDIGCDENPANFMIVDSDKFYLTIPDFPRQINGILEGKPLPTKSTKRSYTTFGVLKDLRCRKV- 1409

  Fly  1247 FPNLKLTIKLKW---------------VC-------LANPNDHHAVMPCAPDKLPEYSSNQ---V 1286
              ..||..|::|               ||       |.|...|..|:    .::|:|..:.   |
pombe  1410 --IAKLVGKVRWRAGFVPERHCDEDCTVCNRKKACRLWNFKPHWQVI----TRIPQYCHDTHYGV 1468

  Fly  1287 HDSFRAFRSLNLNIWISFETKPKAGEDLE----------VDIPSLVLYGSTLRWFESLQLILSGV 1341
            :|::|.|||..::..::.|: |:..:|..          :.:..||....:..|    .|..:.:
pombe  1469 YDAYRDFRSHYIHCSLALES-PRYLDDANAFENVNSYNTIHLTPLVFSHFSSWW----NLFSNNM 1528

  Fly  1342 TRPTRRGPVFNNV--RPRKKPLSRHYKKANLQMCLHKFQVLYWMSHALQKGFQ--------LNGR 1396
            :.|.|.|.:|..:  .|.|| ..||.......:.|....:.:..::...|.:|        |..|
pombe  1529 SYPLRSGNLFPTLDSSPNKK-FGRHLATFKYALELTPLFISHMYNYKTNKNWQDRTASATGLKAR 1592

  Fly  1397 RVSFS------SEHSLTLNPIDDG---------LIHRPRADWSTIYMNC--------ELNDAEIW 1438
            ..:|:      ||.....|..:.|         .:|....|:.||.:..        .|::::..
pombe  1593 VDNFTIDLHQRSEKHEVKNKANLGRKHQEATSMKVHLAEIDFKTIDLRAISASFDEGALDNSDSI 1657

  Fly  1439 LKSIL--TEKMDSSSENLASAAD--------------------------AFKIVRFYFLSVAKVS 1475
            ..::|  .||...|.:|:...|:                          ||. .||.:....|..
pombe  1658 PANVLDEEEKECFSFKNVDGPANWVDIDDYHEADWLLPQQNEKCSIYPLAFS-PRFTYYRHTKCH 1721

  Fly  1476 YGRE----ALIPTTATSTEEDVKAQSTTPTH----------KLVVYDLKGAWTKSNRDVAFALFD 1526
            ...|    .:||.|....:|.        ||          |.|.|:|.....|...:...:..:
pombe  1722 RRNEKNEKEIIPDTCRFGDEF--------THRCLMPSRENPKAVQYELLQKRRKELEEFMSSEQE 1778

  Fly  1527 --SFMKSQKLKNNLSTEAVKSYRKEGPN-----------SAVLKHKRSDSTITLSSTNNEVLPIS 1578
              .|:|||...||.|.|..:.|.:....           ..:||.:.|.|..:..|.|.:|
pombe  1779 RIGFLKSQLESNNDSEEVRQEYEELTKRIVTLSDHYRLLEYLLKDESSCSQASQCSENGQV---- 1839

  Fly  1579 NPNASMKKAPAQIHATAMLQQLIA-EADHKFN------VYSDDHSTQS----------------R 1620
              :.|.......:|  |...:.:| ....|:|      |.|..|..:.                |
pombe  1840 --DLSYASLSESVH--AFNNRFVAHNVQVKWNNFIRNAVMSYVHEVERVRGFAYYMSQKAIVFLR 1900

  Fly  1621 ELQLQGLQACSAQDIIHENWS---ISLVNSQVLLKGCETSGYVIISA-----AKAEILQREHRPV 1677
            :|:   .:..||.|....|::   ....|::.|||      :::..:     .|.....|||...
pombe  1901 DLE---KRTESANDDFFGNYTEDDEDRENARHLLK------FLLEDSKKRFWVKTSDADREHGSE 1956

  Fly  1678 WRERSLISKTTWKGLLECMQYYA--------TVSAGDNNSLLEKEIMWLTVDNIQDKDETVINNL 1734
            ....:.||...:    :.:|.|.        .:....|.   ||.:: :::.::|.|..:|::.:
pombe  1957 EGNTNSISNNEY----DIIQSYVFRFISPQIQLQCSSNP---EKAVI-ISIQSLQIKILSVVDPI 2013

  Fly  1735 ---PDISHLVG--------------SGRSVGGVVSETVGAFLSDNSGGAQ--------------- 1767
               .||::|:.              |.:|...||:   .:.|..|..|.:
pombe  2014 FPDNDINYLIERRFLCKVNESQFFISKKSDFEVVN---ASSLVLNEYGCEHNTVWPPWVPFETTF 2075

  Fly  1768 -----PVQLQRIVSKCKCEFFYVSYGDAIDPNSITEVPPPPSEELQSPWEKQDDPVDAFTLMHHD 1827
                 |....|.:.:......|..:.|.....::        ...::.:|..|...|..|.....
pombe  2076 DFVLTPAAFSRFLHRVSFSVIYTKHNDLRLQETV--------HSTRAFFEDLDTHADTLTFDFPR 2132

  Fly  1828 LDVCTNSLQYAMILDIVNNLLLYVEPQRKQAAEKLTRMRFQL---QLHSTEDQKRPIQQKQTVIR 1889
            :...|:|.||..|..|:.:||||.||.:||..::|..:....   .|..|.:..|.:|.:  |.|
pombe  2133 VVFSTDSSQYYDIFTIITDLLLYKEPAQKQRNQRLEEIMLAADFSDLTGTSEVVRALQAR--VHR 2195

  Fly  1890 SLLMKIRSLEKDTHMISKERIEDGDSLELRQEYD-------HV-QQMIRESKEELNTFSEDLDMM 1946
            .|.:|::                      .|.||       |: ||:..::  ||:...|:|..:
pombe  2196 LLDLKLQ----------------------HQLYDVTFGIYAHIAQQLFLQN--ELHRCGEELYYL 2236

  Fly  1947 LLCYKETQLSQLSKISNVRSDESVTMVRTNEICF---KRAQWRLTETDGQIGIADLVLSAFLYTK 2008
                    :..::.:.|....::  .||:|...|   |...|.|.| |.:....|:.|....:.:
pombe  2237 --------IESIAAVQNRGIHQN--KVRSNLSWFLMAKEVVWHLLE-DNKKPFLDVRLQNATFRR 2290

  Fly  2009 KSKSDDSVEHLLELGNIRMENLLPREIYRDVLLATEIQKDMPVDTH---------KRVLRIFCRE 2064
            ...||.|..:.||:..::..||.|...:.:::        .|...|         ::.:||....
pombe  2291 IENSDASNFNTLEIEFMKGSNLAPGCQFENII--------CPYFNHEFSNEQLLQQKFIRIHWEV 2347

  Fly  2065 KAPVGGISVKEHFEINVAPITIAITKKFYSTMLKFCFPDRDASE------TEVSDELDDNASTSS 2123
            ...|.||.|.:|||||:.|:::.|.::..:.:..:.||:|:.|:      :...|:..:|.|...
pombe  2348 LEAVAGIQVIQHFEINLFPLSLQIEQELATKLFAYAFPNRNESDGFPHIYSRNHDKRKENGSQGE 2412

  Fly  2124 ASTTNLQAK-------------SSTSSSTKRSGKGKKGAKDSEFYVK--IEKDD-----VEKMKE 2168
            |..:|....             .:|.||::|..:.|: |...:|.:.  ::.||     ::.|.:
pombe  2413 ADNSNYSGSLMRRRTNDQEEDALATPSSSRRDSRSKR-ASLIDFTIDKCLDVDDEGRMELQSMLD 2476

  Fly  2169 RAEKNKLFIYIKIPEVPVRVSYKGNKEKNLEDITDYSLVIPTLEYHNVTWTWLDLLLAMKSVSRR 2233
            ||..|.|..|.|||.|.:|:||:|.....||:||.:...:||:||.|...::|||.:.:|....|
pombe  2477 RAGSNMLITYFKIPSVVLRLSYRGTGGLGLENITGFVFTVPTMEYRNEVCSYLDLAMKLKHDLIR 2541

  Fly  2234 VIFS-------QAIKQKLHI--HQRQ 2250
            .:.|       :.:|...|:  |:|:
pombe  2542 TVVSHTGKLLVEKVKGNYHLKEHERE 2567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hob	NP_001303402.1	Fmp27	26..666	CDD:287333	124/706 (18%)
		DUF2405	<887..959	CDD:287288	22/84 (26%)
		Fmp27_GFWDK	1071..1203	CDD:287336	39/157 (25%)
		Apt1	1774..2239	CDD:287340	121/520 (23%)
SPAC3H5.09c	NP_594183.2	Fmp27	33..797	CDD:287333	167/970 (17%)
		DUF2405	826..977	CDD:287288	32/173 (18%)
		Fmp27_SW	1054..1154	CDD:287298	23/105 (22%)
		Fmp27_GFWDK	1174..1330	CDD:287336	39/157 (25%)
		Fmp27_WPPW	1588..2073	CDD:287346	94/521 (18%)
		Apt1	2088..2547	CDD:287340	121/512 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	114	1.000	Domainoid score	I1540
eggNOG	1	0.900	-	-		E1_KOG1910
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003609
OrthoInspector	1	1.000	-	-		oto101261
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15678
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1822
SonicParanoid	1	1.000	-	-		X2484
TreeFam	0	0.000	Not matched by this tool.
	8	8.030