Protein Alignment hob and F31C3.3

DIOPT Version :9

• Sequence 1: NP_001303402.1
• Gene: hob / 38395
• FlyBaseID: FBgn0035420
• Length: 2300
• Species: Drosophila melanogaster
• Sequence 2: NP_493625.4
• Gene: F31C3.3 / 173375
• WormBaseID: WBGene00009285
• Length: 2132
• Species: Caenorhabditis elegans
• Alignment Length: 2349
• Identity: 671/2349 - (28%)
• Similarity: 1069/2349 - (45%)
• Gaps: 369/2349 - (15%)

  Fly     5 LLLFCLALFIFVYWVLPTGISWYLVKRFRVKVRIGRISLPYLSLKNVHISKSGFSVQIEEVCLRS 69
            :||..|.:|:.....:...:||......:..||||.:.  ::.|::|.|..|..|:.|:.:.|
 Worm     3 VLLSLLTVFLIFLSYIDVILSWIFSFVTKSHVRIGGVG--FVQLRDVTIKISWLSIHIDVISL-- 63

  Fly    70 SFFTTEVTKLLSIYIRDIRINKDIHSRQDDSYDQDSYELRRTQTLAGKASEAKGVPDFRQTKVPA 134
            |......|:...:...|:||                 |..:.....||..|.:......:..:..
 Worm    64 SRDRAHPTRFCVLRFDDVRI-----------------EAEKNVQWYGKVEEVEDPSKMIKLNIWT 111

  Fly   135 SIIT-FAQFMAVHVNNISVVLMNNDFDPGWFIHATAKELHLDGSIVQNARVLLVNAALSEAQAKM 198
            |..| .||:..:.||.:.:|:||.  .|...:|.|..||.|:  ..::........:.|..|||:
 Worm   112 SRFTRIAQYCGLVVNRVHIVVMNT--IPDCLLHVTIDELSLE--TFRSREGWQFETSCSLIQAKL 172

  Fly   199 LRHCSSRRQSLENLNKIRPCLGEVSFDMTLDASLFAQGPLSMDTLSLVINNAKSVIHGGLYEFLS 263
            ||...:....|..|:        :.|.::||.....     :|.::|.|::.........:|..|
 Worm   173 LRRGRNSGSLLAELS--------MPFQLSLDIDKDV-----VDNVALRISSPAIAFSDDFFEVFS 224

  Fly   264 EAKRRTSTGQPSRRSTQGLAPSKRSYDNDNYEKLAPIIPKNFNFSIKAAT-----FSAVKENSQN 323
                 :.||...|   .|.|..|...      ||..:.....:||||..|     .:.:|   |.
 Worm   225 -----SWTGYTER---SGSAELKTPL------KLLQMTVVIHSFSIKYTTNNRYITAGIK---QI 272

  Fly   324 DFSAKLQ-SFQISGKFNSKVTDEKTLLPSMLAKLGFHHLDIDTKYEKLLFVEQFTIDSVLEKDIF 387
            .|:..|: |..:..:.|  :.|:  ||.|.|               ||..::..|....|...:.
 Worm   273 QFTRNLETSILVISELN--IADQ--LLRSEL---------------KLTMIKFETAVKTLHCSVE 318

  Fly   388 NLYVKLKTFQIIYNHSEIYDFVNNNFLARQRSSEAQPMQLIHKQKSLPDHLDLDTAVQSNLRANQ 452
            .::.||....:        .:.|.:....||.|                             .:|
 Worm   319 GVHAKLAFHDV--------QWWNKSLKELQRIS-----------------------------GHQ 346

  Fly   453 RREGGVLEWIMQRIVVKGCAELFNVSLLMKLEDEHIAMSVSHTRFLLEQIEEKRSNLYENKFLNL 517
            ...||......| |.::.|          .|..|.:......:.|.|..:..::||....:|
 Worm   347 GSSGGSRGSDYQ-IFLEFC----------DLSAEIVDFESHRSWFKLGFLTFEKSNETSTQF--- 397

  Fly   518 LLNQRQWSMELMVETLWSNLGNSINDTNNLK--KTHSPGSPFFLGVSLVKLCSYANTTKLDISV- 579
                     ||.:|.|:.   .|.:|..:|:  :.|..|...|:|..:.:....:....|||:|
 Worm   398 ---------ELGIEMLFF---GSQDDPESLQQFEYHEWGETLFIGAFIAQWKKLSKKNLLDITVG 450

  Fly   580 -HTFRTEYSMQLAEFVVKSMECLRQYRGIKPKNMSGQSHAR--PNAG-LTLSVQPSQSSTSLRVS 640
             ...:.|:|.|||          ||..|: ...:.|..|:.  ..|| |.|:||.|.:..::.|:
 Worm   451 CDDVKFEWSDQLA----------RQIEGV-IHGILGAEHSANGEEAGNLCLAVQVSANRLAVLVN 504

  Fly   641 VKVKDITAYFVNHHNVYSLLSFSELNL--SRSQSLTTLKLEEFQMAI-MRSMTASSLCLTDFSDV 702
            ...|.           |:.|..|:|..  ...|....||:|..:.|. :|..|...:.|   :|:
 Worm   505 ATNKS-----------YAALCASKLEFITDNWQKDGLLKMEMMRGATGIREDTEDHVLL---ADI 555

  Fly   703 FATCKMI---------------RLEHEQV--------------------------------EGTM 720
            |.:.:::               .||.|:|                                ...:
 Worm   556 FESQRVVEEAAEIHSSPTRRWSHLERERVYKEEREKRANQFEFKFKQFITVNTLEFLIDKQSSVI 620

  Fly   721 GKLSIYIPGNMEATWNSNLHMHLLTLVRDMQDLKTELAIP-ASSVKKTTPKEGFIVELSAERSTI 784
            .|:|::....:...|:..||:.:....:.::.....|:.| .|::.:..|::..|: |:||  ..
 Worm   621 DKISVFTSSEVFLAWSPQLHLIVFDAYKSVKKTVQLLSFPNPSTLTRKVPRKKHII-LTAE--NF 682

  Fly   785 FEIKFSDRHSIQIFVESLFFSQK---ERCIIYAENVFVKIDDQHIFTVKELDLQSVPRLEVLTQE 846
            .|::.....:.::|.:...|..:   .:..:..|.::|.:::|.|.:|....:......:::||.
 Worm   683 VEVQLELARNNRMFWQGEKFRLERLDNQMRMNTEILYVMLNEQRIISVLNPTITVQNSDDLMTQS 747

  Fly   847 RQNFPGFQLPSNKVWVTTIGSFKAIFPYDHDFYNAVNGECTSHFKWLKMVHNYKKKPFTVDSPLP 911
            |..|......:||||:.:...|....|::.||.. :..|.....||:|:||..|||.||..||||
 Worm   748 RSAFATLSSATNKVWIWSADKFMFRLPFNFDFAQ-IFDEFLQIIKWIKVVHEVKKKEFTEASPLP 811

  Fly   912 CDLVIKIKEFLLEISDDPFEVKLRDNYVLLVDEYLESLKRKALFDKKIGELCSERLLLPSGTIEG 976
            .|:.|:..|..||:.||.||.:|:.:..|..||..||.:|:.|.::::..|......|....||.
 Worm   812 SDVRIEFLEVWLELEDDEFENRLKLSAQLKEDEVYESERREQLLEERLFNLKKTAPFLSKEMIEA 876

  Fly   977 LYANLVKKNSEIYIQRSKKIRESGPVRTRLLAWIMTDV-------------NIMAMADTSIHGYN 1028
            :..:|::|||||||:|                |.||:|             |:.|.||.::||..
 Worm   877 IKNSLIEKNSEIYIER----------------WKMTEVSDSPLFLSKWKGWNMRAFADVTLHGTE 925

  Fly  1029 NVTRIMREIDHESPWPEEGLEFSTLWCRGVNISCTEWKFMLRDFPQPMFCVKSMRLYGNLCGAEQ 1093
            ...::|:..|..||.||:  .:||||.|.|.....||....:|:|.....:|.:..:|.|..||.
 Worm   926 KCIQMMKAFDPLSPIPEQ--NYSTLWARAVEFDVDEWTVTFKDYPMKYLDIKDLHFFGTLVAAES 988

  Fly  1094 MGSK-RAKRDVFIDVGEPFGTDVIQRSMPSLKFYHDFDCELESCSYAFGACWEPVMAQCNLSFEK 1157
            :... |:.|:..|.:.|||.|..:.::|..:|||:|..|.....:..:|.||||.::..:|.:..
 Worm   989 LSEDGRSLRECVIPLPEPFPTHSVWKNMSPIKFYYDLQCASTEYNCTYGPCWEPCLSMISLVWNN 1053

  Fly  1158 ISAPSKDPSPPLPFWDKLRLLLHGRLTLIAKQFTILLHASLDPYNTTEEMELTWNNCGIVLTNAK 1222
            |||||||||.|||||||:|.||||:|...:::....:.||.||||.||.:|:.|.:.|:.....:
 Worm  1054 ISAPSKDPSQPLPFWDKMRFLLHGKLLWSSEKLVTTMLASTDPYNETETVEMLWEDFGLDWALGE 1118

  Fly  1223 IMFKGELNVTVRTASRYDDCRLLHFPNLKLTIKLKWVCLANPNDHHAVMPCAPDKLPEYSSNQVH 1287
            |..|..|.:.:||||||||.::|..|:::|.|.|.|.|..:|::||.|..|:|.:||.|||.:.|
 Worm  1119 IRIKSGLKIFLRTASRYDDSQILSLPDVRLKILLGWECGGDPHEHHGVQLCSPQRLPHYSSTEEH 1183

  Fly  1288 DSFRAFRSLNLNIWISFETKPKAGEDLEVD-IPSLVLYGSTLRWFESLQLILSGVTRPTRRGPVF 1351
            ||:|.|||..:|:.::|:..|  |.....| :|:|:||.:|.||.|.....|:...|..|||.||
 Worm  1184 DSYRQFRSSCVNVTLNFDVSP--GSCTSKDKMPNLLLYSNTFRWIEQFLKSLTTKNRNVRRGTVF 1246

  Fly  1352 NNVRPRKKPLSRHYKKANLQMCLHKFQVLYWMSHALQKGFQL--NGRRVSFSSEHSLTLNPIDDG 1414
            .|....|..||:|:.|......|.|..|.|||||:...|||:  :|.:::.|...:::.:.::..
 Worm  1247 GNRVLLKPQLSKHFGKLQFSFSLPKVLVTYWMSHSSPYGFQVFSDGLQLTSSFRQTVSHSSVNRE 1311

  Fly  1415 L-IHRPRA-DWSTIYMNCELNDAEIWLKSILTEKMDSSSENLASAADAFKIVRFYFLSVAKVSYG 1477
            : :.|.:. .|||.:|.|      .|..:    ::....|......|.......:.|...:|.|.
 Worm  1312 MNVQRRKVYSWSTHHMTC------TWWAT----QIHVYGETSRPPTDGSPSEDTFLLGFGRVQYA 1366

  Fly  1478 REALIPTTATSTEEDVKAQSTTPTHKLVVYDLKGAWTKSNRDVAFALFDSFMKSQKLKNNLSTEA 1542
            ||       |...:||      |.||:..:|||.|||..|||....:.|...::..|:..||.:|
 Worm  1367 RE-------TFPGKDV------PLHKVTAFDLKMAWTAQNRDACLTIADGVHRAHMLRRILSNDA 1418

  Fly  1543 VKSYRKEGPNSAVLKHKRSDSTITLSSTNNEVLPISNPNASMKKAPAQIHATA---------MLQ 1598
            ||...       |...:.||:.               .:.|.||...:.|...         ||.
 Worm  1419 VKRLN-------VHLEEASDTP---------------KDPSPKKKEEKTHRRGYSVTEANPWMLT 1461

  Fly  1599 QLIAEADHKFNVYSDDHSTQSREL---QLQGLQACSAQDIIHENWSISLVNSQVLLKGCETSGYV 1660
            |||.|...|...    |..|:.::   .|.|:...:..|:...||.|.|.|||::|||||..|::
 Worm  1462 QLIDEVGTKLVA----HCEQASDVPIDSLLGVHQSTMDDVKLLNWQIDLFNSQLVLKGCERDGFL 1522

  Fly  1661 IISAAKAEILQREHRPVWRERSLISKTTWKGLLECMQYYATVSAGDNNSLLEKEIMWLTVDNIQD 1725
            ::.|||.::||..||.||:...|:||.:|...:..|||:|.:||...|   :::..||..:.|.:
 Worm  1523 LVCAAKTQLLQNFHRNVWKRSLLLSKKSWSAKISGMQYFAPISATGTN---KEKFRWLPREMIDE 1584

  Fly  1726 KDETVINNLPD--ISHLVGSGRSVGGVVSETVGAFLSDNSGGAQPVQLQRIVSKCKCEFFYVSYG 1788
            |.:...:...|  :.....:|.:|||||....    .|.|  .:.||||||||:|.|:.::..:.
 Worm  1585 KSQQDTSGFADDFVQKFTAAGEAVGGVVQSEA----PDES--EEKVQLQRIVSRCSCQIYFCYFS 1643

  Fly  1789 DAIDPNSITEVPPPPSEELQSPWEKQDDP----VDAFTLMHHDLDVCTNSLQYAMILDIVNNLLL 1849
            |.:...|..::..||..:   |..:..:|    :|..||.|:.|:..:||.||.|::||||||.|
 Worm  1644 DELKTESNEDISVPPQLD---PKHQSLNPDAVGIDVLTLKHNMLEATSNSEQYEMVVDIVNNLAL 1705

  Fly  1850 YVEPQRKQAAEKLTRMRFQLQLHSTEDQKRPIQQKQTVIRSLLMKIRSLEKDTHMIS--KERIED 1912
            :|:|.:|:..||..|:||:.|:....:.:..|.:.|:.:|.::...|.||:....:|  .....:
 Worm  1706 FVDPYKKEMGEKRRRLRFECQIMEMVELRAKIMRYQSELREIVSLGRFLERQLFYLSNGNSNSMN 1770

  Fly  1913 GDSLELRQEYDHVQQMI--RESKEELNTFSEDLDMMLLCYKETQLSQLSKISNVRSDESVTMVRT 1975
            |...|...||...|.::  .::|:.:.|.||.|...:.|||:.|::::.:.....:.:.:.:||.
 Worm  1771 GSHCEQPVEYTEDQLVLEAEDTKQRMLTVSEKLATYISCYKQRQVNRVKEFDEKSAKKGMEVVRR 1835

  Fly  1976 NEICFKRAQWRLTETDGQIGIADLVLSAFLYTKKSKSDDSVEHLLELGNIRMENLLPREIYRDVL 2040
            .|:||:...|:|||:||||.:|...:..||||:..:..:..:||.|:|::|:.||||..||:..|
 Worm  1836 FEVCFEDCTWKLTESDGQIALAQTQIRNFLYTRTVRDSNCGDHLFEVGSVRITNLLPDSIYKHAL 1900

  Fly  2041 LATEIQKDMPVDTHKRVLRIFCREKAPVGGISVKEHFEINVAPITIAITKKFYSTMLKFCFPDRD 2105
                 .:|....:.:..:|:|.|:..||||||||||||:|:||:...||.:.:..|::|.||.|:
 Worm  1901 -----HRDETRLSRQPAIRLFVRDMPPVGGISVKEHFELNIAPMVAEITHRLFDKMMRFFFPGRN 1960

  Fly  2106 ASETEVSDELDDNASTSSASTTNLQAKSSTSSSTKRSGKGKKGAKDSEFYVKIEKDDVEKMKERA 2170
               ...:|.||.....|:.|.|...|.:.:..|.|.:.:.....|...     ||||:::|||||
 Worm  1961 ---IHTNDNLDHEEEVSTFSFTRKIASTLSMRSNKSASEKLMLQKSLH-----EKDDIDRMKERA 2017

  Fly  2171 EKNKLFIYIKIPEVPVRVSYKGNKEKNLEDITDYSLVIPTLEYHNVTWTWLDLLLAMKSVSRRVI 2235
            :|...|:|||||||...|||||||:|||.|:..::.:.|..|||...||||||.||:|...:||:
 Worm  2018 DKVNHFMYIKIPEVSFVVSYKGNKDKNLIDVNQFNFIFPLCEYHEQNWTWLDLALAVKQHCKRVL 2082

  Fly  2236 FSQAIKQKL 2244
            ..|.:||||
 Worm  2083 VQQFMKQKL 2091

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hob	NP_001303402.1	Fmp27	26..666	CDD:287333	136/653 (21%)
		DUF2405	<887..959	CDD:287288	31/71 (44%)
		Fmp27_GFWDK	1071..1203	CDD:287336	53/132 (40%)
		Apt1	1774..2239	CDD:287340	168/472 (36%)
F31C3.3	NP_493625.4	Fmp27	21..>209	CDD:370994	50/225 (22%)
		Fmp27_GFWDK	966..1098	CDD:370997	52/131 (40%)
		Apt1	1629..2085	CDD:371000	168/471 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165962
Domainoid	1	1.000	307	1.000	Domainoid score	I736
eggNOG	1	0.900	-	-		E1_KOG1910
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H34730
Inparanoid	1	1.050	834	1.000	Inparanoid score	I234
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46407
OrthoDB	1	1.010	-	-		D26089at2759
OrthoFinder	1	1.000	-	-		FOG0003609
OrthoInspector	1	1.000	-	-		oto17750
orthoMCL	1	0.900	-	-		OOG6_106761
Panther	1	1.100	-	-	LDO	PTHR15678
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1822
SonicParanoid	1	1.000	-	-		X2484
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800