DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32277 and PRSS1

DIOPT Version :9

Sequence 1:	NP_728835.1	Gene:	CG32277 / 38393	FlyBaseID:	FBgn0052277	Length:	261	Species:	Drosophila melanogaster
Sequence 2:	XP_011514713.1	Gene:	PRSS1 / 5644	HGNCID:	9475	Length:	472	Species:	Homo sapiens

Alignment Length:	237	Identity:	79/237 - (33%)
Similarity:	122/237 - (51%)	Gaps:	21/237 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 KIFGGKTTLVKDHSFLVNLRRGGKFRCGGVIISPNCVLTAAHCLEGRYQQVRDLTVHAQQQCLGD 90
            ||.||.........:.|:|..|..| |||.:|:...|::|.||.:.|. ||| |..|..:...|:
Human   248 KIVGGYNCEENSVPYQVSLNSGYHF-CGGSLINEQWVVSAGHCYKSRI-QVR-LGEHNIEVLEGN 309

  Fly    91 DMPPEHVRSAWYVGLSPNYCAQRGLDSDLAVIRLSRPFDIAGNASLVKIDYNDLPPHSNLTVL-- 153
            :   :.:.:|..: ..|.| .::.|::|:.:|:||....|  ||.:..|.....||.:....|
Human   310 E---QFINAAKII-RHPQY-DRKTLNNDIMLIKLSSRAVI--NARVSTISLPTAPPATGTKCLIS 367

  Fly   154 GWGAINEQGHNWNQCLQEANVKLISHRECIKSVGSGWQKVTNNMFCALG--KNARDACQGDSGGP 216
            |||.....|.::...||..:..::|..:|..|...   |:|:|||| :|  :..:|:||||||||
Human   368 GWGNTASSGADYPDELQCLDAPVLSQAKCEASYPG---KITSNMFC-VGFLEGGKDSCQGDSGGP 428

  Fly   217 AIYAGRSVGIVSWGYGCG-SGYPGVYTRLSSPSITYWLKDFI 257
            .:..|:..|:||||.||. ...|||||::.  :...|:|:.|
Human   429 VVCNGQLQGVVSWGDGCAQKNKPGVYTKVY--NYVKWIKNTI 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32277	NP_728835.1	Tryp_SPc	26..246	CDD:214473	76/224 (34%)
CG32277	NP_728835.1	Tryp_SPc	27..246	CDD:238113	75/223 (34%)
PRSS1	XP_011514713.1	Ig	19..119	CDD:299845
		IG_like	29..113	CDD:214653
		Tryp_SPc	248..464	CDD:214473	76/231 (33%)
		Tryp_SPc	249..467	CDD:238113	77/233 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BBP0
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810