DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32271 and PRSS53

DIOPT Version :9

Sequence 1:	NP_728833.1	Gene:	CG32271 / 38392	FlyBaseID:	FBgn0052271	Length:	248	Species:	Drosophila melanogaster
Sequence 2:	XP_011544118.1	Gene:	PRSS53 / 339105	HGNCID:	34407	Length:	623	Species:	Homo sapiens

Alignment Length:	279	Identity:	73/279 - (26%)
Similarity:	107/279 - (38%)	Gaps:	85/279 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 PYLVNLRIGGNFMCGGSLVTPQHVVTAAHCVKGIGASRI---LVVAGVTRLTETGVRSGVDKV-- 96
            |:..::|..|..:|.||||....|:|||||.:...|:.:   .||.|  .|...|:..|.::|
Human    49 PWQASVRRQGAHICSGSLVADTWVLTAAHCFEKAAATELNSWSVVLG--SLQREGLSPGAEEVGV 111

  Fly    97 ---YTPKAYNTRTLTSDVAVLKLKAPISGPKVSTIELCNTS----FKAGDLIKVSGWGQITERNK 154
               ..|:|||..:..||:|:|:|..|     .:...||...    |..|.....:||.|.|...|
Human   112 AALQLPRAYNHYSQGSDLALLQLAHP-----TTHTPLCLPQPAHRFPFGASCWATGWDQDTSDGK 171

  Fly   155 ---------------------------------------AVSMQ-----VRSVDVALIPRKAC-- 173
                                                   |.|:.     :|::.:.||.|..|
Human   172 CWPRLKLGEALCLPSVTVSAPNCPGFQSPLLPRSQTLAPAPSLSPAPGTLRNLRLRLISRPTCNC 236

  Fly   174 ----MSQYKLRGTITNTMFCAS-VPGVKDACEGDSGGPAVYQGQLC----------GIVSWGVGC 223
                :.|..|.......|.|.. .|||:..|:||||||.     ||          ||:|:...|
Human   237 IYNQLHQRHLSNPARPGMLCGGPQPGVQGPCQGDSGGPV-----LCLEPDGHWVQAGIISFASSC 296

  Fly   224 ARKSSPGVYTNVKTVRSFI 242
            |::.:|.:.||.....|::
Human   297 AQEDAPVLLTNTAAHSSWL 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32271	NP_728833.1	Tryp_SPc	24..242	CDD:214473	73/277 (26%)
CG32271	NP_728833.1	Tryp_SPc	25..244	CDD:238113	73/279 (26%)
PRSS53	XP_011544118.1	Tryp_SPc	42..316	CDD:238113	73/279 (26%)
		Tryp_SPc	43..314	CDD:214473	72/276 (26%)
		Tryp_SPc	359..>512	CDD:304450
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24276
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010