DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp83 and HSP82

DIOPT Version :9

Sequence 1:	NP_001261362.1	Gene:	Hsp83 / 38389	FlyBaseID:	FBgn0001233	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_015084.1	Gene:	HSP82 / 855836	SGDID:	S000006161	Length:	709	Species:	Saccharomyces cerevisiae

Alignment Length:	718	Identity:	440/718 - (61%)
Similarity:	562/718 - (78%)	Gaps:	16/718 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 AETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELYIKLI 69
            :|||.|||||.|||||||||.||||||||||||||||||||||||:||:||.:|::..:|:|::.
Yeast     3 SETFEFQAEITQLMSLIINTVYSNKEIFLRELISNASDALDKIRYKSLSDPKQLETEPDLFIRIT 67

  Fly    70 PNKTAGTLTIIDTGIGMTKSDLVNNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAD 134
            |......|.|.|:||||||::|:||||||||||||||||||.||||:||||||||||||.:||||
Yeast    68 PKPEQKVLEIRDSGIGMTKAELINNLGTIAKSGTKAFMEALSAGADVSMIGQFGVGFYSLFLVAD 132

  Fly   135 KVTVTSKNNDDEQYVWESSAGGSFTVRADN-SEPLGRGTKIVLYIKEDQTDYLEESKIKEIVNKH 198
            :|.|.||:||||||:|||:|||||||..|. :|.:||||.:.|::|:||.:||||.:|||::.:|
Yeast   133 RVQVISKSNDDEQYIWESNAGGSFTVTLDEVNERIGRGTILRLFLKDDQLEYLEEKRIKEVIKRH 197

  Fly   199 SQFIGYPIKLLVEKEREKEV--SDDEADDEKKEGDEKKEMETDEPKIEDVGEDEDADKKDKDAKK 261
            |:|:.|||:|:|.||.||||  .::|..||:|:.:|||:.:..:||:|:|  ||:.:||    .|
Yeast   198 SEFVAYPIQLVVTKEVEKEVPIPEEEKKDEEKKDEEKKDEDDKKPKLEEV--DEEEEKK----PK 256

  Fly   262 KKTIKEKYTEDEELNKTKPIWTRNPDDISQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALL 326
            .|.:||:..|.||||||||:|||||.||:||||..||||::|||||.|.||||||||||||||:|
Yeast   257 TKKVKEEVQEIEELNKTKPLWTRNPSDITQEEYNAFYKSISNDWEDPLYVKHFSVEGQLEFRAIL 321

  Fly   327 FIPRRTPFDLFENQKKRNNIKLYVRRVFIMDNCEDLIPEYLNFMKGVVDSEDLPLNISREMLQQN 391
            |||:|.||||||::||:||||||||||||.|..||||||:|:|:||||||||||||:||||||||
Yeast   322 FIPKRAPFDLFESKKKKNNIKLYVRRVFITDEAEDLIPEWLSFVKGVVDSEDLPLNLSREMLQQN 386

  Fly   392 KVLKVIRKNLVKKTMELIEELTEDKENYKKFYDQFSKNLKLGVHEDSNNRAKLADFLRFHTSASG 456
            |::||||||:|||.:|...|:.||.|.::|||..||||:|||||||:.|||.||..||::::.|.
Yeast   387 KIMKVIRKNIVKKLIEAFNEIAEDSEQFEKFYSAFSKNIKLGVHEDTQNRAALAKLLRYNSTKSV 451

  Fly   457 DDFCSLADYVSRMKDNQKHVYFITGESKDQVSNSAFVERVKARGFEVVYMTEPIDEYVIQHLKEY 521
            |:..||.|||:||.::||::|:|||||...|..|.|::.:||:.|||:::|:|||||....|||:
Yeast   452 DELTSLTDYVTRMPEHQKNIYYITGESLKAVEKSPFLDALKAKNFEVLFLTDPIDEYAFTQLKEF 516

  Fly   522 KGKQLVSVTKEGLELPEDESEKKKREEDKAKFESLCKLMKSILDNKVEKVVVSNRLVDSPCCIVT 586
            :||.||.:||: .||.|.:.||.:||::..::|.|.|.:|.||.::|||||||.:|:|:|..|.|
Yeast   517 EGKTLVDITKD-FELEETDEEKAEREKEIKEYEPLTKALKEILGDQVEKVVVSYKLLDAPAAIRT 580

  Fly   587 SQFGWSANMERIMKAQALRDTATMGYMAGKKQLEINPDHPIVETLRQKAD-ADKNDKAVKDLVIL 650
            .|||||||||||||||||||::...||:.||..||:|..||::.|:::.| ....||.||||..|
Yeast   581 GQFGWSANMERIMKAQALRDSSMSSYMSSKKTFEISPKSPIIKELKKRVDEGGAQDKTVKDLTKL 645

  Fly   651 LFETSLLSSGFSLDSPQVHASRIYRMIKLGLGIDEDEPM-TTDDAQSAGDAPSLVEDTEDASHME 714
            |:||:||:||||||.|...||||.|:|.|||.|||||.. |..:|.:|.....:..|||    ||
Yeast   646 LYETALLTSGFSLDEPTSFASRINRLISLGLNIDEDEETETAPEASTAAPVEEVPADTE----ME 706

  Fly   715 EVD 717
            |||
Yeast   707 EVD 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp83	NP_001261362.1	PTZ00272	6..717	CDD:240341	438/715 (61%)
		HATPase_c	28..179	CDD:214643	105/151 (70%)
		HSP90	184..706	CDD:278607	305/525 (58%)
HSP82	NP_015084.1	PTZ00272	3..709	CDD:240341	438/716 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343846
Domainoid	1	1.000	603	1.000	Domainoid score	I24
eggNOG	1	0.900	-	-		E1_COG0326
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H74306
Inparanoid	1	1.050	861	1.000	Inparanoid score	I48
Isobase	1	0.950	-	0	Normalized mean entropy	S263
OMA	1	1.010	-	-		QHG62690
OrthoFinder	1	1.000	-	-		FOG0000295
OrthoInspector	1	1.000	-	-		otm46930
orthoMCL	1	0.900	-	-		OOG6_100204
Panther	1	1.100	-	-	LDO	PTHR11528
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R576
SonicParanoid	1	1.000	-	-		X234
TreeFam	1	0.960	-	-
	16	15.740